Patents Assigned to Hisamitsu Pharmaceutical Co., Ltd.
  • Patent number: 10632065
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 28, 2020
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., ASKA PHARMACEUTICAL CO., LTD.
    Inventors: Shinpei Nishimura, Seiji Tokumoto, Takeshi Ito, Hajime Asada
  • Patent number: 10369115
    Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: August 6, 2019
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Keiichiro Tsurushima, Yasuhisa Kose, Shinji Yamasoto, Seiichiro Tsuru, Takaaki Yoshinaga
  • Publication number: 20190160797
    Abstract: A support film for a tape material is provided that includes a film-shaped support formed of polyurethane, a barrier layer containing an aromatic isocyanate-based polyurethane and a layered inorganic compound and formed on one surface of the support, and an overcoat layer containing a polyvinyl alcohol or an ethylene-vinyl alcohol copolymer and an organometallic chelating agent.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Applicants: TOPPAN PRINTING CO., LTD., HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Koji SAKAIRI, Atsushi MATSUSHIMA, Tomohiro SHINODA, Atsushi SONOBE
  • Publication number: 20190161647
    Abstract: A support film for a tape material, includes a film-shaped support formed of polyurethane; and a barrier layer containing an aromatic isocyanate-based polyurethane and a layered inorganic compound and formed on one surface of the support.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Applicants: TOPPAN PRINTING CO., LTD., HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Koji SAKAIRI, Atsushi MATSUSHIMA, Tomohiro SHINODA, Atsushi SONOBE
  • Patent number: 10080738
    Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: September 25, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
  • Patent number: 9913970
    Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: March 13, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Shunsuke Arami, Makoto Ogura, Seiji Tokumoto
  • Patent number: 9717893
    Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: August 1, 2017
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Ryusuke Fudoji, Makoto Ogura
  • Patent number: 8616371
    Abstract: A pressure-sensitive adhesive tape package is described in which while easiness in applying the adhesive tape is pursued, an effect of saving in resources can be obtained. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, and includes a release sheet releasably attached to the adhesive agent layer. Moreover, in the pressure-sensitive adhesive tape package, the release sheet is bent along a predetermined bending line with the adhesive tape, and the adhesive tape is sealed inside of the bent release sheet.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: December 31, 2013
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Isao Miyachi, Yuichi Takano, Hiromitsu Tsunoda
  • Patent number: 6924410
    Abstract: A patch has a backing which has been subjected to an ultraviolet-screening processing, the backing usually being of one layer. The ultraviolet-screening processing usually uses an organic ultraviolet absorbent and/or an inorganic ultraviolet-screening agent. The patch can contain in its base a medicine of poor photo-stability and a non-steroidal anti-inflammatory analgesic.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: August 2, 2005
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Kiyomi Tsuruda, Yasuhiro Ikeura
  • Patent number: 6844007
    Abstract: A plaster comprising a styrene-isoprene-styrene block copolymer 10-40 wt %, a rosin-based resin 5-30 wt %, a plasticizer 20-70 wt %, polyisobutylene 6-40 wt %, an antioxidant 0.1-5 wt %, and felbinac as a medicinally effective component 1.1-10 wt %, wherein the plaster does not contain crotamiton which is a solubilizer for the felbinac, the felbinac is uniformly dispersed in a semi-solubilized state in the plaster, wherein solubilized felbinac and microcrystalline felbinac coexist in the plaster, and a thickness of the plaster is 50-300 ?m.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: January 18, 2005
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Yasunori Takada, Koji Tanaka, Yasuhiro Ikeura
  • Publication number: 20040071765
    Abstract: Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 15, 2004
    Applicant: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Hirotoshi Adachi, Noriyuki Kuzumaki, Tetsuya Arimoto, Naruhito Higo
  • Patent number: 6608080
    Abstract: Medicinal compositions having an effect of regulating the activation of glycine receptor and novel morphan derivatives. Medicinal compositions comprising morphan derivatives or its salts and a pharmaceutically acceptable carrier. These compositions potentiate or inhibit the activation of glycine receptor, which makes them useful as drugs for the central nervous system. Novel 1- and/or 2-substituted morphan derivatives (2-azabicyclo[3.3.1]nonane derivatives) or salts thereof.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: August 19, 2003
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Chihiro Kibayashi, Takeshi Miyata, Kazuo Takahama, Hidenao Fukushima
  • Patent number: 6451971
    Abstract: Physiologically active peptides possessing cell adhesion inhibitory activity are provided. A physiologically active peptide of this invention is characterized by possessing cell adhesion inhibitory activity and comprising 30 amino acid residues or less, as well as by having an amino acid sequence of the formula: Gly Leu Lys Pro Gly Val Asp X1 Thr Ile Thr X2 X3 Ala X4 wherein X1 represents Tyr or Ala; X2 represents Val or Ala; X3 represents Tyr or Ala; and X4 represents Val or Ala.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: September 17, 2002
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Katsuhiko Akiyama, Takeshi Goto, Fumio Fukai, Masaaki Ueki
  • Patent number: 6330471
    Abstract: The object of the present invention is to provide an iontophoresis electrode device with superior performance which avoids entrance of metal ions from the electrode into the body, is reusable and can be mass produced at low cost, minimizes gas generation which causes polarization, can notably improve transport current, and can prevent skin injury by pH changes during prolonged application. The iontophoresis electrode device of the present invention has a construction provided with a backing 1 having an edge section 1a around an opening and a packing chamber 4 inside, an electrode terminal 2 situated in the packing chamber 4, a non-adhesive gel 5 containing an electrolyte solvent, depolarizer, pH regulator and drug packed in the packing chamber 4, an inert electrode member 3 covering the base of the electrode terminal 2, and a liner 7 attached to the adhesive layer 6 coated on the edge section 1a and covering the opening.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: December 11, 2001
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Naruhito Higo, Tatsuya Meno
  • Patent number: 6267983
    Abstract: A transdermal patch which comprises: a substrate sheet comprises a composite film formed of a resin composition comprising 100 parts by weight of a polyvinyl chloride-polyurethane composite and 2-10 parts by weight of a styrene-ethylene-butylene-styrene copolymer, a first adhesive layer on the one side of the composite film, and a polyalkylene terephthalate film adhered to the one side of the composite film by means of the first adhesive layer, a primer layer which comprises a saturated polyester resin and is formed on the surface of the polyalkylene terephthalate film; and a second adhesive layer comprising a styrene-diene-styrene block copolymer containing a pharmaceutical agent layered on the primer layer.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: July 31, 2001
    Assignees: Bando Chemical Industries, Ltd., Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Kimihiro Fujii, Kazuo Tanaka, Kazuya Ikawa, Yasuhiro Ikeura, Shinji Yamasoto
  • Patent number: 6259946
    Abstract: It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: July 10, 2001
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Naruhito Higo, Kazutaka Inoue, Kenji Mori
  • Patent number: D453682
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: February 19, 2002
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Shigeo Kusumi, Nobuo Tsutsumi
  • Patent number: D686736
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: July 23, 2013
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Takafumi Miyachika, Hiroyuki Taketomi
  • Patent number: D692147
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: October 22, 2013
    Assignee: Hisamitsu Pharmaceutical Co., Ltd.
    Inventors: Takafumi Miyachika, Hiroyuki Taketomi
  • Patent number: D767398
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: September 27, 2016
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Masaki Miyazaki, Shigeo Kusumi