Patents Assigned to Hoechst Aktiengesellschaft
  • Cyclohexapeptides and their mixtures, a process for preparing them, and their use
    Patent number: 6080719
    Abstract: The invention relates to compounds of the formula Icyclo(A-B-C-E-F-(D)-Ala) (I)in which A, B, C, E and F are each independently the residue of a natural amino acid other than cysteine (Cys) and tryptophan (Trp), their mixtures and their physiologically tolerated salts; to a process for their preparation and to their use for preparing a diagnostic agent, a medicament for the treatment or prophylaxis of allergies and infections, or a scientific tool for inhibiting the binding of interleukin-4 (IL-4) to the IL-4 receptor.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: June 27, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Birgit Jordan, Jochen Knolle, Leander Lauffer, Susanne Feiertag, Karl-Heinz Wiesmuller, Gunther Jung
  • Composite material containing aerogel, process for manufacturing the same and the use thereof
    Patent number: 6080475
    Abstract: A composite material comprising aerogel, a process for its preparation, and its use. The invention relates to a composite material comprising from 10 to 95% by volume of aerogel particles and at least one inorganic binder, a process for its preparation, and its use.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: June 27, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Dierk Frank, Andreas Zimmermann, Helmut Stuhler
  • Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use
    Patent number: 6080575
    Abstract: The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B) c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: June 27, 2000
    Assignee: Hoechst Aktiengesellschaft AG
    Inventors: Hans Heinrich Heidtmann, Rolf Mueller, Hans-Harald Sedlacek
  • Polyarylene sulphides with polymer-bound phosphonium salts and process for producing them
    Patent number: 6077918
    Abstract: Phosphonium ionomers which, as random copolymers, are composed of the units (1) and (2) ##STR1## in which Ar-- is a phenylene radical or a biphenylene, naphthylene or anthrylene radical or another divalent aromatic radical and may be different units within the polymer chain;--X-- is an --S--, --SO-- and/or --SO.sub.2 -- unit,where --X-- within the polymer chain may be up to 3 different units;Z is a monovalent or polyvalent opposite ion;Ph is a phenyl radical;m is the charge of the opposite ionand the average degree of polymerization is in the range from 3 to 2000.The polymers can be used for the production of membranes, in particular for electrochemical cells.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: June 20, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Helmut Witteler
  • Bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts
    Patent number: 6077830
    Abstract: The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to the invention contain antibiotics of the moenomycin group which are so-called phosphoglycolipid antibiotics and which are present individually or as a mixture, or derivatives thereof, and bismuth in defined stoichiometric ratios. They are outstandingly suitable, in particular, for controlling Helicobacter pylori and, thus, for example, for the therapy and prophylaxis of gastric disorders.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: June 20, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Michael Kurz, Astrid Markus, Gerhard Seibert
  • Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6075054
    Abstract: Benzoylguanidines of formula I ##STR1## with R(1) to R(4) as defined in the specification, are suitable as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris.They inhibit, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Andreas Weichert, Joachim Brendel, Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Udo Albus, Wolfgang Scholz
  • Membrane anchor/active compound conjugate, its preparation and its uses
    Patent number: 6074650
    Abstract: According to certain embodiments, the invention relates to an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a protein of a virus, a bacterium, a parasite or a tumor antigen. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunogenic composition for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunther Jung, Karl-Heinz Wiesmuller, Hans-Georg Rammensee, Hansjorg Schild, Karl Deres
  • Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
    Patent number: 6075143
    Abstract: There are described N-ethylglycine derivatives of the formula I ##STR1## in which PG is a urethane-type or trityl-type amino protective group which is labile to weak acids, X is NH, O or S, Y is CH.sub.2, NH or O, and B' are bases customary in nucleotide chemistry, the exocyclic amino or hydroxyl groups of which being protected by suitable, known protective groups, or are base substitute compounds, and their salts with tert-organic bases, as well as a process for their preparation. The N-ethylglycine derivatives of the formula I are used in the preparation of PNA and PNA/DNA hybrids.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Eugen Uhlmann, Jochen Knolle
  • Metallizing thermoplastics
    Patent number: 6074740
    Abstract: Metallized moldings of polymer mixtures comprise a thermoplastic and a filler. The thermoplastic polymer has a melting point of more than 100.degree. C. and may be selected from the group consisting of fluoropolymers, polyamides, polycarbomates, polyesters, polyimides, liquid crystalline polymers, polymethyl methacrylates, polyphenylene oxides, polysulfones, polyurethanes and silicones. The filler may comprise oxidized polyarylene sulfide polyarylene sulfide, polyimide, aromatic polyester, or polyether ketone.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: June 13, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Helmut Scheckenbach, Georg Frank
  • Biaxially oriented polyproylene film having a high surface modulus
    Patent number: 6071598
    Abstract: A biaxially oriented polypropylene film is described. The base ply of the film essentially consists of a polypropylene prepared by means of a metallocene catalyst. This polypropylene is distinguished by a mean isotactic block length of greater than 40, an n-heptane soluble fraction of less than 1% and a ratio of the weight average molecular weight M.sub.w to the number average molecular weight M.sub.n of less than 4.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: June 6, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Peiffer, Detlef Busch, Thomas Dries, Gunter Schlogl, Anreas Winter
  • Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
    Patent number: 6071953
    Abstract: Chromans of formula I ##STR1## with the meanings of R(A), R(B) and R(1) to R(8) stated in the specification are suitable for producing a medicament for blocking the K.sup.+ channel that is opened by cyclic adenosine monophosphate (cAMP); also for producing medicaments for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and the intestinal region, in particular the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal disorders, for the treatment and prevention of all types of arrhythmias, including atrial, ventricular and supraventricular arrhythmias, for controlling reentry arrhythmias and for preventing sudden heart death as a result of ventricular fibrillation.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: June 6, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Jochen Lang, Joachim Brendel, Uwe Gerlach, Klaus Weidmann
  • Simplified method for the production of vinyl glycine (2-aminobut-3-enoic acid) and a convenient resolution of a derivative
    Patent number: 6069272
    Abstract: The invention relates to a three-step synthesis of vinyl glycine (1) using a cheap, commercially available starting material (3-butenenitrile (2)) and using cheap, simple reagents. Also disclosed is a convenient optical resolution of the N-tert.butyloxycarbonyl derivative by papain-catalyzed enantioselective esterification in a two-phase system.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: May 30, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: David Herbert George Crout, Keith Oliver Hallinan
  • Modified oligonucleotides, their preparation and their use
    Patent number: 6066720
    Abstract: The invention relates to novel modified oligonucleotides which contain at least one 8-azapurine base and form more stable hybridization complexes with nucleic acids; To a process for their preparation, and to their use as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology, and as a pharmaceutical or diagnostic agent.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: May 23, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Seela, Sigrid Lampe
  • Process for the preparation of low-dust granules
    Patent number: 6066365
    Abstract: The present invention relates to a process for the preparation of low-dust granules, which comprises applying an aqueous solution or suspension of a hydrate-forming compound to a particulate starting material, the particulate starting material being at a temperature below the transition temperature of the hydrate-forming compound during the application of the aqueous solution or suspension and the aqueous solution being at a temperature above the transition temperature, effecting granulation subsequently or simultaneously and, if desired, drying the granules obtained.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: May 23, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Jaekel, Gerd Reinhardt, Gerhard Noltner
  • Transport protein which effects the transport of cationic xenobiotics and/or pharmaceuticals, DNA sequences encoding it and their use
    Patent number: 6063623
    Abstract: A transport protein has been cloned which is present in liver epithelial cells and kidney epithelial cells and in intestinal cells and is responsible for transporting cationic pharmaceuticals and/or xenobiotics. This transport protein has been described more specifically by its DNA and amino acid sequences, and various uses are disclosed which are, in particular, of great importance for developing novel medicaments.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: May 16, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hermann Koepsell, Dirk Grundemann, Valentin Gorboulev
  • Process for amplifying nucleic acids using DNA/PNA primers
    Patent number: 6063571
    Abstract: The present invention relates to a novel advantageous process for amplifying nucleic acids using DNA/PNA primers and a temperature-stable polymerase enzyme.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: May 16, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Eugen Uhlmann, Gerhard Breipohl, Steven A. Benner, Michael Lutz
  • Cycloolefin copolymers and uses thereof
    Patent number: 6063886
    Abstract: Disclosed is a cycloolefin copolymer which is obtained from (A) a straight-chain or branched .alpha.-olefin of 2 to 20 carbon atoms, (B) a specific cycloolefin and (C) an aromatic vinyl compound and has an intrinsic viscosity [.eta.] of 0.1 to 10 dl/g, wherein the content of constituent units derived from the cycloolefin (B) and the content of constituent units derived from the aromatic vinyl compound (C) satisfy a specific relation. The cycloolefin copolymer has high heat resistance, low moisture absorption and small birefringence.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: May 16, 2000
    Assignees: Mitsui Chemicals, Hoechst Aktiengesellschaft
    Inventors: Masayoshi Yamaguchi, Kazuyuki Takimoto
  • Transport protein which effects the transport of cationic xenobiotics and/or pharmaceuticals, DNA sequences encoding it and their use
    Patent number: 6063766
    Abstract: A transport protein has been cloned which is present in liver epithelial cells and kidney epithelial cells and in intestinal cells and is responsible for transporting cationic pharmaceuticals and/or xenobiotics. This transport protein has been described more specifically by its DNA and amino acid sequences, and various uses are disclosed which are, in particular, of great importance for developing novel medicaments.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: May 16, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hermann Koepsell, Dirk Grundemann, Valentin Gorboulev
  • Biaxially oriented polypropylene film having improved migration values
    Patent number: 6063483
    Abstract: A biaxially oriented polypropylene film is described. The base ply of the film contains at least 90% by weight of a polypropylene prepared by means of a metallocene catalyst. This polypropylene is distinguished by a mean isotactic block length of greater than 40, an n-heptane soluble fraction of less than 1% and a ratio of the weight average molecular weight M.sub.w to the number average molecular weight M.sub.n of less than 4.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: May 16, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Peiffer, Detlef Busch, Thomas Dries, Gunter Schlogl, Andreas Winter, Detlef Schuhmann
  • Biaxially oriented polypropylene film having improved tear propagation resistance
    Patent number: 6063482
    Abstract: A biaxially oriented polypropylene film is described. The base ply of the film essentially consists of a polypropylene prepared by means of a metallocene catalyst. This polypropylene is distinguished by a mean isotactic block length of greater than 40, an n-heptane soluble fraction of less than 1% and a ratio of the weight average molecular weight M.sub.w to the number average molecular weight M.sub.n of less than 4.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: May 16, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Herbert Peiffer, Detlef Busch, Gunter Schlogl, Thomas Dries, Andreas Winter