Patents Assigned to Hoechst Japan Limited
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Patent number: 6559473Abstract: An organic light-emitting diode with high luminance and high efficiency comprising an anode, an organic pn-junction and a cathode layered sequentially in this order, wherein the organic pn-junction emits light by an electric current passing through the diode in an electric field applied between the anode and the cathode, characterized in that the organic pn-junction is composed of an organic p-type luminescent-semiconductor thin film and an organic n-type luminescent-semiconductor thin film, wherein one surface of the organic p-type luminescent-semiconductor thin film is in contact with the anode and another surface of the organic p-type luminescent-semiconductor thin film is in contact with the organic n-type luminescent-semiconductor thin film, and one surface of the organic n-type luminescent-semiconductor thin film is in contact with the cathode and another surface of the organic n-type luminescent-semiconductor thin film is in contact with the organic p-type luminescent-semiconductor thin film and whereiType: GrantFiled: June 16, 1997Date of Patent: May 6, 2003Assignee: Hoechst Japan LimitedInventors: Nu Yu, Wen-Bing Kang, Akihiko Tokida
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Patent number: 6110639Abstract: A radiation-sensitive composition comprising:an acid-generating compound capable of generating an acid upon exposure to radiation and represented by the formula (I): ##STR1## wherein X, Y and R.sup.1 to R.sup.5 have the following meanings: X and Y: independently a direct bond, C.sub.1 -C.sub.8 alkylene, C.sub.1 -C.sub.4 alkene, --O--R.sup.11 --O-- (wherein R.sup.11 is an alkylene group having 1 to 4 carbon atoms), --NH--, --O--, --S--, --SO.sub.2 --, --CO--, --COO-- or --CONR.sup.12 -- (wherein R.sup.12 is a hydrogen atom, C.sub.1 -C.sub.8 alkyl, alkylaryl, halogenated alkyl, halogenated aryl, a halogen atom, alkoxy, phenoxy, alkylsulfonyl-oxy, halogenated alkylsulfonyl-oxy, or substituted or unsubstituted arylsulfonyl-oxy);R.sup.1 to R.sup.4 : a hydrogen atom, C.sub.1 -C.sub.Type: GrantFiled: June 26, 1997Date of Patent: August 29, 2000Assignee: Hoechst Japan LimitedInventors: Seiya Masuda, Satoru Funato, Natsumi Kawasaki
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Patent number: 6080720Abstract: This invention relates to a composition for metabolic bone diseaese and/or bone fractures which comprises a pharmaceutically acceptable carrier and human neurotrophin-3 (NT-3).This invention also relates to a method for the treatment and/or prevention of metabolic bone diseaese or bone fractures which comprises administering to a patient in need of said treatment and/or prevention a medicament containing an effective amount of human neurotrophin-3 (NT-3).Type: GrantFiled: July 21, 1995Date of Patent: June 27, 2000Assignee: Hoechst Japan LimitedInventors: Akira Kudo, Tohru Nakanishi, Masaharu Takigawa
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Patent number: 6037521Abstract: The invention relates to an animal model of human Alzheimer's disease that is useful for determining the mechanism of the disease and for developing and testing potential therapeutic drugs. More particularly, the present invention relates to the creation of transgenic non-human mammalian animals having integrated into their genome an exogenous DNA construct that encodes a portion of a .beta.-amyloid precursor protein ("APP") and that is designed to overexpress in various types of animal tissues.Type: GrantFiled: November 14, 1994Date of Patent: March 14, 2000Assignee: Hoechst Japan LimitedInventors: Masahiro Sato, Takashi Kobayashi, Norihiro Tada, Mikio Shoji, Takeshi Kawarabayashi
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Patent number: 5932688Abstract: An improved polybenzimidazole wherein the total concentration of metals other than alkali metal and alkaline earth metals is 10 ppm or less. The resulting polybenzimidazole is industrially useable in parts or components of apparatus for the manufacture of semiconductors and display devices.Type: GrantFiled: January 14, 1997Date of Patent: August 3, 1999Assignee: Hoechst Japan LimitedInventor: Makoto Murata
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Patent number: 5908828Abstract: The present invention provides synthetic peptide derivatives represented by the formulaP.sup.1 -R.sup.1 -P.sup.2wherein P.sup.1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P.sup.2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R.sup.1 denotes a linker with a property that does not interfere with the activity of the each peptide P.sup.1 and P.sup.2 to bind N-terminal end of the peptides P.sup.1 and P.sup.2.The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier.The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.Type: GrantFiled: June 30, 1995Date of Patent: June 1, 1999Assignee: Hoechst Japan LimitedInventors: Takashi Kurita, Tomoaki Matsumoto, Reiko Kikuno, Yoko Otawara-Hamamoto, Gerhard Breipohl
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Patent number: 5902876Abstract: Improved process for producing a polybenzimidazole compound in solution by dissolving a fully dried polybenzimidazole of the following general formula (1) or (2) in N,N-dimethylacetamide of a sufficiently reduced water content at an elevated temperature of 260.degree. C. or higher in an inert gas atmosphere and a solution of the polybenzimidazole compound produced by the process. The solution remains useful for an extended time without using metal salts or any other stabilizers: ##STR1## where R.sup.1, R.sup.2 and R.sup.5 are tetra-, di- and trivalent aromatic groups, respectively; R.sup.3, R.sup.4 and R.sup.6 are each independently a hydrogen atom, an alkyl group or an aryl group; n is an integer of 2 or more.Type: GrantFiled: June 18, 1997Date of Patent: May 11, 1999Assignee: Hoechst Japan LimitedInventors: Makoto Murata, Toru Nakamura
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Patent number: 5888964Abstract: A method for increasing the placental blood flow, which comprises administering a human-originated antithrombin-III. The human-originated antithrombin-III increases the placental blood flow in mammals and particularly improves intrauterine growth retardation caused by a decreased blood flow. The method is highly safe to the mother and fetus, since it uses human-originated AT-III as an active ingredient, thereby enabling effective and safe treatment of intrauterine growth retardation (IUGR) and the like.Type: GrantFiled: April 24, 1996Date of Patent: March 30, 1999Assignees: The Green Cross Corporation, Hoechst Japan LimitedInventors: Hiroshi Shinyama, Toshiaki Akira, Takeshi Uchida, Masahiro Watanabe
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Patent number: 5882843Abstract: A photosensitive resin composition is disclosed.The photosensitive resin composition is characterized by containing (a) a reaction product of a polymer having a specific segment with (3,4-epoxycylohexyl)-methyl methacrylate, (b) a polymerization initiator allowing the initiation of the polymerization of said reaction product when irradiated with an actinic radiation, and (c) a solvent. Preferably, the composition further contains (d) a thermal crosslinker, a compound having a polymerizable unsaturated bond and/or a pigment in addition to the above ingredients.Type: GrantFiled: November 14, 1995Date of Patent: March 16, 1999Assignee: Hoechst Japan LimitedInventors: Takanori Kudo, Yuko Nozaki, Kazuya Nagao, Yuki Nanjo
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Patent number: 5869638Abstract: A bone-related protein named OSF-4 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein of the cadherin family.OSF-4 acts as an adhesion molecule or a growth factor which takes part in the process of osteogenesis at the site of bone induction. OSF-4 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.Type: GrantFiled: October 25, 1996Date of Patent: February 9, 1999Assignee: Hoechst Japan LimitedInventors: Sunao Takeshita, Makoto Okazaki, Shinji Kawai, Atsushi Tsujimura, Egon Amann
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Patent number: 5853471Abstract: Disclosed herein is a composition for anti-reflection coating which comprises a perfluoroalkyl sulfonic acid, an organic amine, a polyvinyl pyrrolidone, a water-soluble alkylsiloxane polymer, and water. The composition is able to be an anti-reflection coating film which has a low refractive index, reduces the degree of forming insoluble layer, and does not generate fine particles and minute crystalline matters in its surface layer.Type: GrantFiled: April 9, 1997Date of Patent: December 29, 1998Assignee: Hoechst Japan LimitedInventors: Takeo Yoshida, Hatsuyuki Tanaka
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Patent number: 5849993Abstract: Transgenic mice carrying a recombinant DNA construct comprising the gene encoding diphtheria toxin A chain operably linked to a osteocalcin promoter. The transgenic mice can be used as a model for metabolic bone diseases since they have decreased bone mass associated with a marked reduction in the number of osteoblasts.Type: GrantFiled: April 25, 1995Date of Patent: December 15, 1998Assignee: Hoechst Japan LimitedInventors: Norihiro Tada, Masahiro Sato, Takashi Kobayashi, Toru Ikeda, Katsuiku Hirokawa
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Patent number: 5846690Abstract: A radiation-sensitive composition is disclosed which includes (a) a binder insoluble in water but soluble in or capable of being swelled in an aqueous alkali solution, (b) a dissolution inhibitor composed of (b1) a poly(N,O-acetal) having a general formula: ##STR1## wherein R.sup.3 is alkyl or substituted or unsubstituted aryl, R.sup.4 is a divalent group selected from alkylene, cycloalkylene, alkene or alkyne, R.sup.5 is alkyl, alkene, alkyne or cycloalkyl, X is --OCO--, --CO-- or --NHCO--, and p is a number not less than 1, and/or (b2) a phenol compound having a hydroxyl group which is protected by a group which can be cleaved in the presence of an acid, (c) a photosensitive compound capable of generating an acid when exposed to an active radiation, (d) a base capable of being decomposed when exposed to an active radiation to form a neutral compound derived therefrom, (e) a plasticizer, and (f) a solvent.Type: GrantFiled: March 14, 1996Date of Patent: December 8, 1998Assignee: Hoechst Japan LimitedInventors: Munirathna Padmanaban, Yoshiaki Kinoshita, Hiroshi Okazaki, Seiya Masuda, Natsumi Kawasaki, Satoru Funato, Georg Pawlowski
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Patent number: 5843319Abstract: A process for producing a solution of a basic or non-basic sulfonium compound (A) of formulae II-V: ##STR1## wherein R.sup.5, R.sup.6 and R.sup.7 each independently represent a C.sub.1 -C.sub.18 alkyl, aryl or heteroaryl group or an aryl group mono-, di- or tri-substituted with an alkyl, an alkylaryl, an aryl, a halogen, an alkoxy, a phenoxy, a thiophenol, a phenylsulfonyl or a phenylsulphenyl;Y represents (CH.sub.2).sub.n (wherein n is 0 or 1), O or S;R.sup.8 and R.sup.9 represent a C.sub.1 -C.sub.4 alkyl, alkoxy or a halogen;R.sup.10 and R.sup.11 represent a C.sub.1 -C.sub.4 alkyl, alkoxy or a halogen;n is 5 or 6; andX.sub.2.sup.- represents a basic anion having a pK.sub.B value of -3 to +5; comprising the steps of:(a) dissolving a sulfonium salt (B) in a metal-ion free polar or non-polar solvent to form a solution, said sulfonium salt (B) being selected from said formulae II-V, wherein R.sup.5 to R.sup.11, Y and n of said sulfonium salt (B) have the sane meaning as above and X.sub.2.sup.Type: GrantFiled: July 29, 1997Date of Patent: December 1, 1998Assignee: Hoechst Japan LimitedInventors: Klaus Juergen Przybilla, Takanori Kudo, Seiya Masuda, Yoshiaki Kinoshita, Natsumi Suehiro, Munirathna Padmanaban, Hiroshi Okazaki, Hajime Endo, Ralph Dammel, Georg Pawlowski
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Patent number: 5773191Abstract: A radiation-sensitive composition is disclosed which includes:(a) a copolymer represented by the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group, Ar is a substituted or unsubstituted phenylene group or a substituted or unsubstituted cyclohexylene group, X is a divalent group represented by --SO.sub.2 -- or --CO--, m and n are individually an integer not less than 1;(b) a dissolution inhibitor composed of a compound represented by the general formula: ##STR2## wherein R.sup.3 is an alkyl group or a substituted or unsubstituted aryl group, R.sup.4 is an alkylene group, a cycloalkylene group, an alkenylene group or an alkynylene group, R.sup.Type: GrantFiled: July 24, 1996Date of Patent: June 30, 1998Assignee: Hoechst Japan LimitedInventors: Munirathna Padmanaban, Yoshiaki Kinoshita, Satoru Funato, Natsumi Kawasaki, Hiroshi Okazaki, Georg Pawlowski
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Patent number: 5770142Abstract: Provided is a process for manufacturing sintered polybenzimidazole (PBI) articles at high yields, said articles having neither voids nor porous, low-strength parts resulting from oxidative deterioration. To produce said sintered PBI articles from a particulate PBI resin, said PBI resin is compacted in a closed mold, the mold is heated up to a predetermined temperature of from 350.degree. to 600.degree. C. without applying any external pressure thereto, then, after having heated up to said predetermined temperature, the mold is pressed to have a predetermined external pressure of from 140 to 1400 kg/cm2 at said predetermined temperature whereby the resin is sintered for from 60 to 350 minutes under that conditions, and finally the sintered PBI article is cooled and taken out of the mold.Type: GrantFiled: June 13, 1997Date of Patent: June 23, 1998Assignee: Hoechst Japan LimitedInventors: Yoshisato Sasaki, Minoru Kurisaki
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Patent number: 5767146Abstract: An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (Ill): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.Type: GrantFiled: September 22, 1997Date of Patent: June 16, 1998Assignees: Hoechst Japan Limited, Koichi ShudoInventors: Koichi Shudo, Tatsuo Sugioka, Mizuho Inazu, Hideyuki Tanaka, Tsutomu Inoue, Kazuyuki Kitamura
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Patent number: 5756664Abstract: The present invention provides the sequence of the novel bone-related protein OSF-2 which can be obtained from mammalian bone tissues. The invention further provides a method of production of OSF-2 by recombinant techniques.Type: GrantFiled: April 21, 1995Date of Patent: May 26, 1998Assignee: Hoechst Japan LimitedInventors: Egon Amann, Yoko Otawara-Hamamoto, Reiko Kikuno, Sunao Takeshita, Kenichi Tezuka
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Patent number: 5738972Abstract: A chemically amplified resist material comprising: a) a homopolymer or a copolymer of hydroxystyrene or hydroxystyrene partly protected by a group sensitive to an acid such as a tetrahydropyranyl or t-butoxycarbonyl group, b) a dissolution inhibitor such as poly(N,O-acetal) or phenol or bisphenol protected by a group cleavable with an acid, c) a photosensitive compound capable of generating an acid upon exposure, d) a base capable of degrading upon radiation to regulate the line width in a period between the exposure step and the processing steps after exposure, e) a low-molecular weight phenolic or polyphenolic compound having a structure represented by the following general formula or a mixture of the phenolic or polyphenolic compounds: ##STR1## where n is an integer of 1 to 5, m is an integer of 0 to 4, n+m.ltoreq.5, and p is an integer of 1 to 10, each R is a C.sub.1 -C.sub.12 alkyl group or an unsubstituted or substituted cycloalkyl group or a C.sub.1 -C.sub.Type: GrantFiled: May 28, 1997Date of Patent: April 14, 1998Assignee: Hoechst Japan LimitedInventors: Munirathna Padmanaban, Natsumi Suehiro, Yoshiaki Kinoshita, Satoru Funato, Seiya Masuda, Hiroshi Okazaki, Georg Pawlowski
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Patent number: 5726148Abstract: A method of treating metabolic bone diseases comprising using a pharmaceutical composition which comprises as an active ingredient IL-1 receptor, a soluble fragment consisting of an extracellular domain of IL-1R or a fragment thereof derived from mammals. The composition has a bone resorption inhibiting activity and is useful for the therapy and prophylaxis of metabolic bone diseases.Type: GrantFiled: June 7, 1995Date of Patent: March 10, 1998Assignee: Hoechst Japan LimitedInventors: Masakazu Katoh, Kazuyuki Kitamura