Patents Assigned to Hoechst Marion Roussel, Inc.
  • Publication number: 20020004601
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Application
    Filed: January 24, 2001
    Publication date: January 10, 2002
    Applicant: Hoechst Marion Roussel, Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • Patent number: 6229014
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: May 8, 2001
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Patent number: 6180786
    Abstract: The present invention is new 3-(heterocyclic)-propenoic acid derivatives and pharmaceutical compositions thereof. These new 3-(heterocyclic)-propenoic acid derivatives are useful as NMDA antagonist.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: January 30, 2001
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: William A. Metz, Jr.
  • Patent number: 6156901
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: December 5, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Patent number: 6133467
    Abstract: This invention relates to the compounds of 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)methyloxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxyphenylsilyl)methyloxy]phenol, polymorphs thereof and their pharmaceutically acceptable salts, useful as antiatherosclerotic agents.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: October 17, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Michael L. Edwards, Mark J. Vaal, Roger A. Parker, James E. Matt, Kim S. Chen, Mark T. Yates
  • Patent number: 6121463
    Abstract: The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1, R.sub.5 and R.sub.6 are independently a C.sub.1 -C.sub.6 alkyl group;R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or a C.sub.1 -C.sub.6 alkyl group;Z is thio, oxy or a methylene group;A is a C.sub.1 -C.sub.4 alkylene group;X is thio or oxy; andG.sub.1 and G.sub.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or --C(O)--(CH.sub.2).sub.n --CH.sub.3 and n is an integer 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: September 19, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Roger A. Parker, Michael L. Edwards, Mark J. Vaal, James E. Matt, Kim S. Chen, Mark T. Yates, Paul S. Wright, Steven J. Busch
  • Patent number: 6114572
    Abstract: The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1 is C.sub.1 -C.sub.6 alkyl; andR.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl;or a stereoisomer thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: September 5, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Roger A. Parker, Paul S. Wright, Steven J. Busch, Kim S. Chen, Mark T. Yates
  • Patent number: 6075144
    Abstract: There are disclosed compounds having the formula ##STR1## wherein n is 1-4; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.2 or --NR.sub.3 R.sub.4 where R.sub.2 is hydrogen or loweralkyl, and R.sub.3 and R.sub.4 are independently hydrogen, loweralkyl or cycloalkyl; R is hydrogen, loweralkyl or loweralkylcarbonyl; and R.sub.1 is hydrogen, loweralkyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, furylloweralkyl, thienylloweralkyl, pyridinylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof which are useful for enhancing memory.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: June 13, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gregory Michael Shutske, Kevin James Kapples
  • Patent number: 6069232
    Abstract: This invention relates to polyfluoroalkyl tryptophan tripeptides and to compositions containing them. The compounds are highly selective thrombin inhibitors which provide anticoagulant effects useful in the treatment of thrombin conditions and in preventing the coagulation of stored whole blood and blood products.
    Type: Grant
    Filed: August 26, 1996
    Date of Patent: May 30, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: J. Anthony Malikayl, Joseph P. Burkhart, Robert J. Broersma, Norton P. Peet
  • Patent number: 6063793
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: May 16, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • Patent number: 6043240
    Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 28, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Edward J. Glamkowski, Yulin Chiang, Joseph T. Strupczewski, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegeler
  • Patent number: 6039974
    Abstract: The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising,(a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of;(I) carnauba wax in an amount of about 59% to about 81% by weight of Formulation (A); and(ii) a suitable antiadherent in an amount of about 0.25% to about 2.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: March 21, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: David D. MacLaren, John R. Lefler, Sharon K. Minish
  • Patent number: 6037353
    Abstract: The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxy;R.sub.2 is hydrogen;or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;n is an integer of from 1 to 5;R.sub.3 is --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched;each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen;or a pharmaceutically acceptable salt and individual isomers thereof.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: March 14, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: James K. Woodward, Richard A. Okerholm, Mark G. Eller, Bruce E. McNutt
  • Patent number: 6034241
    Abstract: A process of converting a hydroxy heteroaromatic compound to an arylamine, comprising the steps of:(1) treating a salt of a hydroxy heteroaromatic compound with an alkylating agent; and(2) treating the reaction mixture with a Smiles solvent system and raising the temperature of the reaction mixture; andA compound made according to the above process.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: March 7, 2000
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Norton P. Peet, John J. Weidner
  • Patent number: 6028083
    Abstract: The present invention is directed to esters of (+)-.alpha.-(2,3 Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A receptor and are useful in treating various conditions such as, for example, psychoses such as schizophrenia.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: February 22, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Albert A. Carr, Raymond W. Kosley, Jr., Luc Van Hijfte
  • Patent number: 6022880
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: February 8, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Richard Charles Effland, Joseph Thomas Klein, Lawrence Leo Martin, Gregory M. Shutske, Kevin J. Kapples, John D. Tomer, IV
  • Patent number: 6022877
    Abstract: The present invention is directed to the use of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol in treating Depressive Disorders and Bipolar Disorders.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: February 8, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: Cesare Mondadori
  • Patent number: 6017923
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: January 25, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Jeffrey S. Sabol, Sai P. Sunkara, Shawn C. Miller
  • Patent number: 6013645
    Abstract: The present invention relates certain mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholestrolemia.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: January 11, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gary A. Flynn, John F. French, Richard C. Dage
  • Patent number: 6008348
    Abstract: This invention relates to compounds of the formula wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: December 28, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Mark G. Palermo, Lawrence L. Martin, Peter A. Nemoto