Patents Assigned to Hokkaido System Science Co., Ltd.
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Publication number: 20220401466Abstract: An agent for inhibiting the action of a target RNA based on RNA interference and ASO with a passenger strand and a guide strand for a target RNA, wherein both ends of double-stranded RNA formed pairing of the passenger strand and the guide strand are blunt ends, and one or two or more selected from the group consisting of the units represented by formula (1) and formula (2) below at the following positions (a) and (b): (a) 5? end side and 3? end side of the passenger strand, (b) 3? end side of the guide strand (in which X represents an oxygen atom or sulfur atom), (in which X represents an oxygen atom or sulfur atom).Type: ApplicationFiled: August 20, 2020Publication date: December 22, 2022Applicants: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, NICCA CHEMICAL CO., LTD., HOKKAIDO SYSTEM SCIENCE CO., LTD.Inventors: Hiroyuki ASANUMA, Yukiko KATO, Keiji MURAYAMA, Toshiki TSUBOI, Tomohito DOKE, Takuji ISHIMOTO, Shoichi MARUYAMA, Toshio KOKURYO, Ayako KOTO, Isao ISHIMARU, Ryoichi ASAI, Ayaka NAKASHA, Tomoe SUGITA, Keisuke NISHI, Motoki YUGUCHI, Masanori MATSUMOTO
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Patent number: 9284344Abstract: A nucleic acid synthesis method enabling a reaction in a fluid (flow) with a highly dispersible liquid-phase support to improve coupling efficiency is provided. The method for synthesizing an oligonucleotide comprising: sequentially condensing and oxidizing a nucleoside phosphoramidite compound in the presence of an acid/azole complex compound using a starting raw material, i.e.Type: GrantFiled: May 30, 2012Date of Patent: March 15, 2016Assignee: HOKKAIDO SYSTEM SCIENCE CO., LTD.Inventors: Shokaku Kim, Masanori Matsumoto
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Publication number: 20150112053Abstract: A nucleic acid synthesis method enabling a reaction in a fluid (flow) with a highly dispersible liquid-phase support to improve coupling efficiency is provided. The method for synthesizing an oligonucleotide comprising: sequentially condensing and oxidizing a nucleoside phosphoramidite compound in the presence of an acid/azole complex compound using a starting raw material, i.e.Type: ApplicationFiled: May 30, 2012Publication date: April 23, 2015Applicant: HOKKAIDO SYSTEM SCIENCE CO., LTD.Inventors: Shokaku Kim, Masanori Matsumoto
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Patent number: 8920832Abstract: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell. The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.Type: GrantFiled: September 29, 2011Date of Patent: December 30, 2014Assignee: Hokkaido System Science Co., Ltd.Inventors: Hiroshi Kikuchi, Hideo Kobayashi, Kouichi Hashimoto, Ayako Iijima, Daigo Asano, Junko Yasuda
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Publication number: 20130149369Abstract: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell. The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.Type: ApplicationFiled: September 29, 2011Publication date: June 13, 2013Applicants: DAIICHI FINE CHEMICAL CO., LTD., HOKKAIDO SYSTEM SCIENCE CO., LTD.Inventors: Hiroshi KIKUCHI, Hideo Kobayashi, Kouichi Hashimoto, Ayako Iijima, Daigo Asano, Junko Yasuda
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Patent number: 8227248Abstract: To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells. The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.Type: GrantFiled: June 29, 2007Date of Patent: July 24, 2012Assignee: Hokkaido System Science Co., Ltd.Inventors: Hiroshi Kikuchi, Hideo Kobayashi, Kouichi Hashimoto, Ayako Iijima, Daigo Asano
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Publication number: 20100055684Abstract: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell. The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.Type: ApplicationFiled: June 29, 2007Publication date: March 4, 2010Applicants: HOKKAIDO SYSTEM SCIENCE CO., LTD., DAIICHI FINE CHEMICAL CO., LTD.Inventors: Hiroshi Kikuchi, Hideo Kobayashi, Kouichi Hashimoto, Ayako Iijima, Daigo Asano, Junko Yasuda