Patents Assigned to Hokuriku Pharmaceutical Co., Ltd.
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Patent number: 5344828Abstract: Novel polycyclic compounds represented by the following formula: A--(CH.sub.2).sub.n --COOR.sup.1, wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represented by the following formula: ##STR1## wherein X represents a hydrogen atom or a halogen atom; and Y represents a methylene group, an oxygen atom, or a sulfur atom, or A is a group represented by the following formula: ##STR2## and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same, an antiallergic agent and an agent for bronchial asthma comprising the same, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.Type: GrantFiled: March 1, 1991Date of Patent: September 6, 1994Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Hiroyuki Sawanishi, Yasuo Ito, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Kouji Morikawa
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Patent number: 5213806Abstract: A pharmaceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80% by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.Type: GrantFiled: November 25, 1991Date of Patent: May 25, 1993Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Ito, Hideo Kato, Osamu Nagata, Masaharu Yamazaki, Takeo Ishibashi, Masakazu Kitayama
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Patent number: 5153207Abstract: A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed.Type: GrantFiled: May 3, 1990Date of Patent: October 6, 1992Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Ito, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Hiroyuki Nishino, Jun Sakaguchi
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Patent number: 5126337Abstract: A thiazetoquinoline-3-carboxylic acid derivative represented by the general formula (I) ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a fluorine atom or a chlorine atom; R.sub.3 is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl, or alkoxycarbonyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group, and a pharmacologically acceptable salt thereof, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for the treatment of an infectious disease by administering the same, are disclosed.Type: GrantFiled: April 5, 1990Date of Patent: June 30, 1992Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Ito, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Noriyuki Yagi, Toshihiko Yoshida, Tomio Suzuki
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Patent number: 5095022Abstract: A piperidine derivative represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; X represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--; Y represents an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represented an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).Type: GrantFiled: June 13, 1990Date of Patent: March 10, 1992Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Ito, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Hiroyuki Nishino, Jun Sakaguchi
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Patent number: 4983633Abstract: Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.Type: GrantFiled: September 2, 1988Date of Patent: January 8, 1991Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Hiroyuki Nishino, Jun Sakaguchi
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Patent number: 4971990Abstract: Phenoxyethylamine derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.5 represent lower-alkyl, R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or ##STR2## represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R.sub.4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha..sub.1 -blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.Type: GrantFiled: January 24, 1989Date of Patent: November 20, 1990Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Kazuya Mitani, Shunichiro Sakurai
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Patent number: 4943581Abstract: An isoquinolinesulfonamide selected from those represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and each represent hydrogen or lower-alkyl, and X represents hydrogen or halogen, and pharmacologically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and use thereof in the treatment of circular disorders, are disclosed.Type: GrantFiled: June 26, 1989Date of Patent: July 24, 1990Assignees: Hokuriku Pharmaceutical Co., Ltd., Hiroyoshi HidakaInventors: Hiroyoshi Hidaka, Toshio Tanaka, Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Kazuya Mitani, Shunichiro Sakurai
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Patent number: 4912116Abstract: A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl, lower-alkoxy, or cycloalkyl having 3-8 carbon atoms, two of which R.sub.1, R.sub.2, and R.sub.3 groups may combine to form methylenedioxy or ethyleneoxy, R.sub.4 represents hydrogen or a lower-alkyl, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically-acceptable acid addition salt thereof, is disclosed.Type: GrantFiled: December 22, 1987Date of Patent: March 27, 1990Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Kouji Morikawa, Toshie Yamauchi
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Patent number: 4792547Abstract: Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastorenteric trouble, hay fever urticaria, allertic rhinitis, and allergic conjunctivitis, and pharmaceutical compositions thereof, are disclosed. The compounds have the formula I as follows: ##STR1## wherein R represents hydrogen or ##STR2## wherein R.sub.1 and R.sub.2 may be the same or different and each independently represents hydrogen, straight or branched-chain lower-alkyl, or cycloalkyl having three to six carbon atoms inclusive, phenyl which may be substituted with halogen, lower-alkyl, or lower-alkoxy, or wherein R.sub.1 and R.sub.2 together represent alkylene of four to six carbon atoms, inclusive, optionally interrupted by one or two nitrogen atoms or one oxygen atom and said ring being optionally substituted by straight or branched-chain lower-alkyl having one to six carbon atoms inclusive, hydroxy, or phenyl,and pharmaceutically-acceptable salts thereof.Type: GrantFiled: December 15, 1986Date of Patent: December 20, 1988Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Kazuya Mitani
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Patent number: 4780465Abstract: A stable isotonic aqueous solution of the compound 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline -3-carboxylic acid, or a pharmaceutically-acceptable salt thereof, having a pH of 3 to 6.5 and isotonized with a polyalcohol or boric acid is disclosed.Type: GrantFiled: May 20, 1987Date of Patent: October 25, 1988Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Hideo Terayama, Satoshi Takei
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Patent number: 4638009Abstract: Certain 4'-alkyl-2-methyl-3-pyrrolidinopropiophenones, acid addition salts thereof, their method of preparation, pharmaceutical compositions embodying the same, and a method of muscle relaxation therewith, are disclosed.Type: GrantFiled: January 25, 1984Date of Patent: January 20, 1987Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itho, Hideo Kato, Nobuo Ogawa, Kagari Yamagishi, Eiichi Koshinaka, Hiroyuki Nishino
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Patent number: 4612329Abstract: Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.Type: GrantFiled: October 11, 1985Date of Patent: September 16, 1986Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Sakae Kurata, Hiroyuki Nishino, Toshihiko Yoshida
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Patent number: 4534980Abstract: Creams for external or topical use comprising ketoprofen as an effective component and crotamiton as an agent for preventing crystalline precipitation of the effective component. The creams possess an antiinflammatory and antipyretic effect and are excellent in permeation and absorption into the skin which enables the topical and external use of the creams.Type: GrantFiled: July 23, 1984Date of Patent: August 13, 1985Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Kugako Matsumura, Tomoyasu Nishikawa, Akira Hisano, Takehisa Yamada, Eiichi Koshinaka
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Patent number: 4528287Abstract: The invention is concerned with the novel piperazinylquinoline-3-carboxylic acids represented by formula (I) ##STR1## or a pharmacologically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as the therapeutic agent against bacteria.Type: GrantFiled: September 17, 1984Date of Patent: July 9, 1985Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itoh, Hideo Kato, Nobuo Ogawa, Eiichi Koshinaka, Tomio Suzuki, Noriyuki Yagi
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Patent number: 4525356Abstract: Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an ethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R.sub.3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1; X and Y, which must be different, represent a hydrogen atom or methyl group. A represents an amino group having the formula ##STR2## wherein, R.sub.4 and R.sub.5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R.sub.6 represents a lower alkyl group and n represents 2 or 3, are disclosed, as well as pharmaceutical compositions thereof and method of treating therewith.The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.Type: GrantFiled: October 28, 1983Date of Patent: June 25, 1985Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itho, Hideo Kato, Nobuo Ogawa, Kagari Yamagishi, Eiichi Koshinaka, Kazuya Mitani
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Patent number: 4478838Abstract: 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 5 to 7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof are disclosed.The 1-(3,4,5-trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives are useful as vasodilator agents.Type: GrantFiled: November 15, 1982Date of Patent: October 23, 1984Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Yasuo Itho, Hideo Kato, Eiichi Koshinaka, Nobuo Ogawa, Sakae Kurata, Kagari Yamagishi
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Patent number: 4205074Abstract: Phenyl- or thienyl-substituted quinolizidines and indolizidines as well as quaternary salts thereof are disclosed. These compounds are useful as pharmaceutical agents exhibiting strong spasmolytic, anti-ulcer, anti-histaminic and antiemetic activities with minimized side effects such as thirst and dilation of the pupil.Phenyl- or thienyl-substituted quinolizidine-methanols and indolizidine-methanols which are starting materials of the aforementioned quinolizidine and indolizidine compounds are also useful as having spasmolytic, anti-ulcer, anti-histaminic and anti-emetic activities.Type: GrantFiled: March 1, 1979Date of Patent: May 27, 1980Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Hideo Kato, Eiichi Koshinaka
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Patent number: 4198431Abstract: N-(3-trifluoromethylphenyl)anthranilic acid esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 4 to 8 carbon atoms, are disclosed.The esters are useful as anti-inflammatory agents, particularly for an external application, with reduced toxicity. These esters are of great importance as non-steroid type anti-inflammatory agents for topical administration.Type: GrantFiled: February 2, 1978Date of Patent: April 15, 1980Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventor: Hideo Kato
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Patent number: 4169144Abstract: There is provided piperazine or homopiperazine-monoalkanol esters and salts thereof. These compounds are prepared by esterification of the corresponding alkanol compounds.The novel compounds are characterized by therapeutic activity and specifically, analgetic, coronary vasodilative, anti-convulsant, and blood pressure-decreasing properties.Type: GrantFiled: June 20, 1977Date of Patent: September 25, 1979Assignee: Hokuriku Pharmaceutical Co., Ltd.Inventors: Hideo Kato, Takaaki Mouri, Tomoyasu Nishikawa