Abstract: A drug delivery device may include a base to be percutaneously affixable in an attachment zone of a synovial joint and a sustained-release drug carrier coupled to the base. The drug delivery device may also include an access device to provide access to the attachment zone. The attachment zone may comprise a non-articulating portion of a bone and/or cartilage with the synovial joint and the drug carrier may elute the drug into the synovial fluid sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours.

Abstract: Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.

Abstract: An approach is provided for patient positioning. A patient is arranged on a table having a positioning assembly coupled thereto, the positioning assembly including a plurality of spatially configurable members. A spatial configuration of at least one of the plurality of spatially configurable members is arranged to support the patient in a multipoint bending position during a medical procedure.

Abstract: A method of intra-articular drug delivery may include selecting an attachment zone in a synovial joint; affixing a drug release device in the attachment zone, the drug release device comprising a base affixable in the attachment zone, a sustained-release drug carrier, and a drug, the device positioned so that the device releases the drug into the synovial fluid of the synovial joint, and so that agitation of the synovial fluid facilitates elution of the drug from the drug release device.

Abstract: A prosthetic joint according to the present invention includes a first implant component for attachment to a first bone and a second implant component for attachment to a second bone. The first implant component has a condylar portion that includes first and second condylar bearing surfaces and similarly, the second implant component has bearing surfaces that receive and are complementary to the first and second condylar bearing surfaces. Each of the first and second condylar bearing surfaces and each of the bearing surfaces of the second implant component has a cross-section in a coronal plane that exhibits two different radii and a contact point is established between the first and second condylar bearing surfaces and the bearing surfaces of the second implant component. The bearing surfaces of the respective implant components are configured such that varus and valgus rotation of the first implant component relative to the second implant component causes the contact point to move outwardly.

Abstract: A knee joint prosthesis includes a femoral component having a first condylar bearing surface and a second condylar bearing surface. Each of the first and second condylar bearing surfaces has a cross-section in a coronal plane that exhibits at least two different radii. The prosthesis also includes a tibial component and an insert component associated with the tibial component. The insert component has bearing surfaces that are complementary to the first and second condylar bearing surfaces, wherein a contact point is established between the bearing surfaces of the insert component and the first and second condylar bearing surface. In accordance with the present invention and as a result of the above construction, varus and valgus rotation of the femoral component relative to the insert component causes the contact point to move laterally as the knee is rotated. By shifting the contact pointy laterally/outwardly, the knee stability (i.e., stiffness) gradually increased.

Abstract: Apparatus and methods for total elbow replacement are provided to allow a surgeon to intraoperatively select a linked or unlinked constraint by utilizing a connection located on the body of the ulnar and/or humeral stem. Additional modularity also allows the selection of a cemented or cementless stem as described herein. The modularity and adjustability provides a number of advantages.

Abstract: A knee joint prosthesis includes a femoral component having an anterior side, a posterior side, a pair of laterally spaced condylar portions, and an intercondylar portion joining the condylar portions and including a recess. A cam surface is located adjacent the intercondylar recess on the anterior side of the femoral component and has a saddle shape that is defined by an at least substantially concave first radius of curvature and a convex third radius of curvature that is perpendicular to the concave first radius of curvature. The prosthesis also includes a tibial component including a platform having an upper surface that includes first and second laterally spaced concavities. Each concavity is adapted for receiving one condylar portion of the femoral component. The tibial component has a tibial post for reception in the intercondylar recess of the femoral component.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.

Abstract: A knee joint prosthesis includes a femoral component having an anterior side, a posterior side, a pair of laterally spaced condylar portions, and an intercondylar portion joining the condylar portions and including a recess. A cam surface is located adjacent the intercondylar recess on the anterior side of the femoral component and has a saddle shape that is defined by an at least substantially concave first radius of curvature and a convex third radius of curvature that is perpendicular to the concave first radius of curvature. The prosthesis also includes a tibial component including a platform having an upper surface that includes first and second laterally spaced concavities. Each concavity is adapted for receiving one condylar portion of the femoral component. The tibial component has a tibial post for reception in the intercondylar recess of the femoral component.

Abstract: Expanding cannula and retractor devices and methods of use are provided. An expanding cannula and retractor device includes a first tube, a second tube positioned within the first tube, and an expandable continuous membrane connecting distal portions of the first and second tubes. The membrane can expand into an annulus based on the movement of the second tube relative to the first tube in order to contact tissue and maintain the position of the device.

Abstract: External fixation devices and methods of use are provided. A device for external fixation of a joint includes a first pin block for connection to a first skeletal element and a second pin block for connection to a second skeletal element. The device includes a connection assembly that is releasably attached to at least one of the pin blocks. The device is locked in an original position when the connection assembly is attached to both of the pin blocks, and is unlocked when the connection assembly is detached from at least one of the pin blocks.

Abstract: The present invention is directed to a method of treating bone length discrepancies and angular deformities in a patient in need thereof, where the method involves radiofrequency ablation epiphysiodesis of a physeal plate. Specifically, the method treats long bone discrepancies with a minimally invasive procedure. The present invention is also directed to a method of inhibiting bone growth, where the method involves exposing a physeal growth plate to radiofrequency ablation epiphysiodesis.

Abstract: The present disclosure provides methods of reducing pregnancy loss or miscarriage in patients by administering compounds that inhibit tissue factor (TF) expression and/or activity on neutrophils and/or monocytes, such as for example, statins, and methods of diagnosing patients having an increased risk of miscarrying.

Abstract: Provided herein are compositions and methods that inhibit expression of Adam9 gene products, such as ADAM9 mRNA and/or ADAM9 polypeptides, as a therapeutic approach for the treatment of pathological neovascularization and conditions associated with angiogenesis.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.

Abstract: The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds.

Abstract: This invention relates to BMP fusion genes, BMP fusion proteins, and methods for making BMP fusion genes and BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.

Abstract: A surgical device for use in attaching a first member (e.g., soft-tissue) to a second member (e.g., a bone) includes a suture anchor that has a body having a first end; a pointed tip at an opposite second end; and a contoured outer surface. An anchor head that is coupled to the body at the first end has an opening to permit attachment of one or more suture to the body. The suture anchor also includes a reservoir formed in the body and being open at the first end thereof and closed at an opposite end. The reservoir is configured to store and release at least one of a drug, a therapeutic agent, a growth factor, or a combination thereof from a top surface of the anchor body into a site of an interface between the first and second members to promote healing or therebetween or limit post-operative pain.