Abstract: This invention relates to a method for enhancing cell differentiation in malignant cells by exposing the cells to a 1.alpha.-hydroxylated vitamin D derivative characterized by a 17-side chain greater in length than the cholesterol or ergosterol side chains.The method finds application in the treatment of neoplastic diseases including leukemoid diseases and, specifically, leukemia.
May 30, 1985
Date of Patent:
January 5, 1988
Howard W. Bremer
Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Voula Ostrem