Abstract: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
Type:
Grant
Filed:
August 6, 2009
Date of Patent:
January 21, 2014
Assignee:
Hydra Biosciences, Inc.
Inventors:
Jayhong Chong, Christopher Fanger, Magdalene M. Moran, Elisha Singer, Timothy Strassmaier, Howard Ng
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Application
Filed:
January 29, 2013
Publication date:
January 9, 2014
Applicant:
Hydra Biosciences, Inc.
Inventors:
Magadalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy S. Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
Abstract: The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.
Abstract: The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Grant
Filed:
July 1, 2011
Date of Patent:
March 5, 2013
Assignee:
Hydra Biosciences, Inc.
Inventors:
Magdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.
Type:
Grant
Filed:
June 23, 2008
Date of Patent:
April 24, 2012
Assignee:
Hydra Biosciences, Inc.
Inventors:
Howard Ng, Manfred Weigele, Magdalene Moran, Jayhong Chong, Christopher Fanger, Glenn R. Larsen, Donato Del Camino, Neil Hayward, Steven P. Adams, Amy Ripka
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Application
Filed:
July 1, 2011
Publication date:
January 19, 2012
Applicant:
Hydra Biosciences, Inc,
Inventors:
Magdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Grant
Filed:
September 14, 2007
Date of Patent:
August 16, 2011
Assignee:
Hydra Biosciences, Inc.
Inventors:
Magdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Application
Filed:
March 4, 2011
Publication date:
June 23, 2011
Applicant:
Hydra Biosciences, Inc.
Inventors:
Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, Magdalene M. Moran, Howard Ng, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen
Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Type:
Application
Filed:
February 7, 2011
Publication date:
June 16, 2011
Applicant:
Hydra Biosciences, Inc.
Inventors:
Jayhong A. Chong, Christopher Fanger, Glenn R. Larsen, William C. Lumma, JR., Anu Mahadevan, Peter Meltzer, Magdalene M. Moran, Amy Ripka, Dennis John Underwood, Manfred Weigele, Xiaoguang Zhen