Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A computer-implemented method is disclosed. The method comprises classifying an arterial Doppler ultrasound waveform using the arterial Doppler ultrasound waveform and/or a set of features extracted from the arterial Doppler ultrasound waveform using one or more trained machine learning models to identify whether a peripheral arterial disease condition is present and/or to predict a medical outcome related to peripheral arterial disease. The method comprises, upon identifying the presence of the peripheral arterial disease condition and/or predicting the medical outcome, signalling the presence of the peripheral arterial disease condition and/or the medical outcome.

Abstract: The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.

Abstract: The invention relates to polymeric compositions, nanoparticles and vaccines comprising polymeric compositions. The invention extends to medical uses of the polymeric compositions, nanoparticles and vaccines. The invention further extends to methods of producing the polymeric compositions and nanoparticles.

Abstract: An image processing system to estimate depth for a scene. The image processing system includes a fusion engine to receive a first depth estimate from a geometric reconstruction engine and a second depth estimate from a neural network architecture. The fusion engine is configured to probabilistically fuse the first depth estimate and the second depth estimate to output a fused depth estimate for the scene. The fusion engine is configured to receive a measurement of uncertainty for the first depth estimate from the geometric reconstruction engine and a measurement of uncertainty for the second depth estimate from the neural network architecture, and use the measurements of uncertainty to probabilistically fuse the first depth estimate and the second depth estimate.

Abstract: Method of forming a cement-based material pad (3) comprising a plurality of drainage holes and forms for use in such a method.

Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.

Abstract: A flavivirus Envelope Dimer Epitope (EDE) and isolated neutralizing antibody or antigen binding fragment thereof directed against the EDE for use in vaccinating an individual against one or more flaviviruses wherein the EDE is a stabilized recombinant flavivirus are provided. The dimer is: covalently stabilized with at least one disulphide inter-chain bond or one sulfhydryl-reactive crosslinker between the two sE monomers, and/or by being formed as a single polypeptide chain, and/or by linking the two sE monomers through modified sugar, and/or non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1)/domain 3 (D3) linker of each monomer. The dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from DENV-1, DENV-2, DENV-3, DENV-4, Zika and/or other flavivirus.

Abstract: There is provided apparatus for controlling the delivery of insulin to a subject. The apparatus comprises a first input (18) for receiving neural information from the subject indicative of prospective or actual food and/or drink intake and a second input (15) for receiving a signal indicative of the subject's blood glucose level (BG). The apparatus further comprises a processor or processors (10) configured to determine food and/or drink characteristics based on the received neural information and to determine an amount of insulin to be delivered based on the measured blood glucose levels (BG) and the determined food and/or drink characteristics, and an output for providing an insulin pump control signal (12) indicative of the determined amount of insulin.

Abstract: A method for enabling movement of an object, having a plurality of degrees of freedom, by a user. The method comprising: receiving a first and second plurality of reference signals from first and second test subjects respectively, generated in response to respective reference intended movements; and determining a set of first of and second profiles. The method also comprises determining profile-pairs, which each comprise a first profile and a second profile that correspond to the same degree of freedom of the object; determining a reference set of profiles based on a mathematical combination of each profile-pair; and providing the reference set of profiles for determining an intended movement of the object based on a plurality of user signals received from a respective plurality of different sensors associated with the user. The intended movement comprises simultaneous movements with respect to at least two degrees of freedom of the plurality of degrees of freedom.

Abstract: An apparatus for treating benign paroxysmal positional vertigo, BPPV, comprises at least a processing unit and a feedback mechanism. The processing unit is configured to receive data indicative of a manoeuvre carried out by a user and to compare the received data to data indicative of a predefined manoeuvre for treating BPPV, and the feedback mechanism is configured to provide feedback to the user in accordance with the result of the comparison between the received data and the predefined manoeuvre. In some embodiments the feedback may be provided as audio output, for example in the form of intelligible speech descriptive of a similarity and/or a difference between the manoeuvre carried out by the user and the predefined manoeuvre. A corresponding method and computer program for performing the method are also disclosed.

Abstract: Certain examples described herein enable a robotic device to accurate map a surrounding environment. The robotic device uses an image capture device and at least one of the image capture device and the robotic device move within the environment. Measurements associated with movement of at least one of the image capture device and the robotic device are used to determine a state of the robotic device. The state of the robotic device models the image capture device and the robotic device with respect to a model of the environment that is constructed by a mapping engine. By comparing the state of the robotic device with a measured change in the robotic device, an accurate representation of the state of the robotic device may be constructed. This state is used by the mapping engine to update the model of the environment.

Abstract: A method of adaptively determining one or more compensation factors in a closed-loop insulin delivery system comprising a continuous glucose level sensor, an insulin pump, and an insulin reservoir, where the system determines an insulin meal bolus taking into account an estimated amount of carbohydrates to be ingested, CHO, a difference between a currently sensed glucose level, G, and a glucose set point, Gsp, and at least one compensation factor, ICR.

Abstract: The invention relates to methods for the hydrogenation of nitrogen by reducing a N?N bond in a metal complex comprising a N?N bond by reacting the metal complex with a Lewis acid, wherein the metal complex comprises Cr, Mo, W, Mn, Tc, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd or Pt.

Abstract: The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.

Abstract: The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: An apparatus, computer program and method is described comprising: separating neuron discharge patterns obtained from electromyography signals into one or more frequency band signals based on bandpass filter configuration parameters and converting one or more of said one or more frequency band signals into a one or more control signals, wherein said one or more control signals include one or more first control signals, wherein the or each first control signal is an independent augmented control signal.

Abstract: Systems and methods for autonomously herding birds in accordance with embodiments of the invention are illustrated. One embodiment includes an autonomous flock herding system, including a bird location sensor, a drone; and a control system, including a processor, and a memory, the memory containing a flock herding application, where the application directs the processor to obtain bird position data from the at least one bird location sensor, where the bird position data describes the location of birds in a flock of birds, determine if the flock of birds will enter a protected zone, generate a set of waypoints using a flock dynamics model, instruct the unmanned aerial vehicle to navigate to at least one waypoint in the set of waypoints such that the flock of birds will, in response to the presence of the unmanned aerial vehicle at the at least one waypoint, change trajectory away from the protected zone.

Abstract: This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.