Patents Assigned to Imperial Innovations Limited
  • Patent number: 10125182
    Abstract: Peptide hormone analogs of the formula X-V are provided herein, wherein X is a glucagon analog or a GLP1 analog, and V is a C-terminal extension amino acid sequence comprising at least four amino acid residues, at least three of said residues being His. Also provided herein are pharmaceutical compositions comprising said analogs, and methods of using said analogs for the treatment of conditions such as obesity and diabetes.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 13, 2018
    Assignee: Imperial Innovations Limited
    Inventor: Stephen Robert Bloom
  • Publication number: 20180320200
    Abstract: The invention provides hybrid and recombinant phagemid vectors for expressing a transgene in a target cell transduced with the vector. A recombinant phagemid particle comprises at least one transgene expression cassette which encodes an agent which exerts a biological effect on the target cell, characterised in that the phagemid particle comprises a genome which lacks at least 50% of its bacteriophage genome. The invention extends to the use of such phagemid expression systems as a research tool, and for the delivery of transgenes in a variety of gene therapy applications, DNA and/or peptide vaccine delivery and imaging techniques. The invention extends to in vitro, in vivo or in situ methods for producing viral vectors, such as recombinant adeno-associated viruses (rAAV) or lentivirus vectors (rLV), and to genetic constructs used in such methods.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 8, 2018
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Amin Hajitou, Paladd Asavarut, Teerapong Yata
  • Publication number: 20180315933
    Abstract: A compound for an infrared light sensing device may be represented by a particular chemical formula and may be included in an infrared light sensing device. An image sensor may include the infrared light sensing device, and an electronic device may include the image sensor.
    Type: Application
    Filed: April 25, 2018
    Publication date: November 1, 2018
    Applicants: Samsung Electronics Co., Ltd., IMPERIAL INNOVATIONS LIMITED
    Inventors: Moon Gyu HAN, Kyung Bae Park, Yong Wan Jin, Chul Joon Heo, Brett Baatz, Martin Heeney, Minwon Suh, Yang Han, Ji-Seon Kim
  • Publication number: 20180305501
    Abstract: The present invention provides methods for producing block copolymers, either by the sequential addition of monomers, or using a “one-pot” method. The invention also relates to novel methods for producing polyesters by ring opening lactides and/or lactones and by copolymerising anhydrides and epoxides.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 25, 2018
    Applicant: Imperial Innovations Limited
    Inventors: Charlotte Katherine Williams, Charles Romain, Michael Kember
  • Patent number: 10090872
    Abstract: A signal processing method for estimating a frequency domain representation of signal from a series of samples distorted by an instrument function, the method comprising obtaining the series of samples; obtaining a set of coefficients that fit a set of basis functions to a complex exponential function wherein the set of basis functions comprises a plurality of basis functions each defined by a shifted version of the instrument function in a signal domain; estimating the frequency domain representation of the signal based on the series of samples and the coefficients. This is wherein the estimate of the instrument function is based on a characterization of the instrument function in the frequency domain at frequencies associated with the complex exponential function.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: October 2, 2018
    Assignees: IMPERIAL INNOVATIONS LIMITED, THE CHINESE UNIVERSITY OF HONG KONG
    Inventors: Jose Antonio Uriguen, Pier Luigi Dragotti, Thierry Albert Jean-Louis Blu
  • Patent number: 10090839
    Abstract: Reconfigurable Integrated Circuit with On-Chip Configuration Generation A circuit and method are provided in which reconfiguration is achieved through the modification of a dynamic data path using configuration information generated on the basis of run-time variables. Rather than storing a plurality of pre-set configurations, this can allow configurations optimized to processing tasks to be implemented during operation.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: October 2, 2018
    Assignee: Imperial Innovations Limited
    Inventors: Xinyu Niu, Wayne Luk
  • Publication number: 20180237784
    Abstract: The present invention relates to identification of therapeutic agents for the treatment, diagnosis, and prevention of pulmonary hypertension.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 23, 2018
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Eduardo OLIVER-PEREZ, Lan ZHAO, Martin WILKINS, Tim AITMAN
  • Patent number: 10052317
    Abstract: The invention provides a neurokinin 3 receptor (NKR3) antagonist for use in the treatment, prevention or amelioration of hot flushes in a human subject, for example a menopausal woman or a patient undergoing cancer therapy which affects secretion of sex steroids. The invention also provides a NKR3 antagonist together with a further active agent, and a composition and a kit comprising a NKR3 antagonist and a further active agent. The invention further provides a NKR3 agonist or exogenous NKB for the induction of hot flushes in a human subject.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: August 21, 2018
    Assignee: Imperial Innovations Limited
    Inventors: Waljit Dhillo, Channa Jayasena
  • Patent number: 10030106
    Abstract: The present invention provides methods for producing block copolymers, either by the sequential addition of monomers, or using a “one-pot” method. The invention also relates to novel methods for producing polyesters by ring opening lactides and/or lactones and by copolymerizing anhydrides and epoxides.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: July 24, 2018
    Assignee: Imperial Innovations Limited
    Inventors: Charlotte Katherine Williams, Charles Romain, Michael Kember
  • Patent number: 10030818
    Abstract: A liquid-flow monitoring device (10) arranged to monitor the flow of liquid in a conduit. The device (10) comprises sampling means (20), processing means (30) and data storage means (40). The sampling means is arranged to receive data substantially continuously from a sensor (12) indicative of at least one variable sensed by the sensor (12) indicative of fluid flow in a conduit and to sample the data to produce a stream of sampled data. The processing means (30) is arranged to process the stream of sampled data to extract at least one sub-sampled stream therefrom, the sub-sampled stream comprising a plurality of data sets, each data set being a statistical subset of the stream of sampled data over a respective data-set period. The data storage means (40) is arranged to store the at least one sub-sampled stream.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: July 24, 2018
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Asher John Hoskins, Ivan Iordanov Stoianov
  • Patent number: 9995774
    Abstract: Determining a property of an electrical signal at a node instant at the current instant (INSTC); determining a previous function indicative of a property of the signal at the node at a previous instant; determining an error function in a previous frequency estimation at the node at a previous instant; determining a first current function indicative of the property of the signal at the node at INSTC in accordance with the determined property, the previous function, and the error function; receiving, from another node, a second current function indicative of a property of an electrical signal at the at least one other node at INSTC; combining the first current function and the second current function to produce a current combined function (CCF) indicative of a property of the signal at the node at INSTC; and estimating a current frequency of the signal at the node in accordance with the CCF.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: June 12, 2018
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Danilo Mandic, Yili Xia, Dahir Dini
  • Patent number: 9994675
    Abstract: The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerizing carbon dioxide and an epoxide.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: June 12, 2018
    Assignee: Imperial Innovations Limited
    Inventors: Charlotte K. Williams, Michael Kember, Paul Knight
  • Publication number: 20180143145
    Abstract: A sensor comprises a first resonator operable at microwave and/or millimetre wave frequencies and having a first value of quality factor which is equal to or greater than moo at a frequency in a range 1 to 100 GHz and a second resonator having a second value of quality factor which is less than the first value of quality factor and which is positioned and orientated with respect to the first resonator so as to be inductively coupled to the first resonator, the second resonator comprising first and second electrically-conductive regions separated by a gap which provides a sensing region.
    Type: Application
    Filed: November 23, 2016
    Publication date: May 24, 2018
    Applicant: Imperial Innovations Limited
    Inventors: Norbert Klein, Clare Watts, Stephen Hanham
  • Patent number: 9954243
    Abstract: A fuel cell comprising at least two stacked fuel cell boards (22) which each comprise a membrane of substantially gas impervious electrolyte material and at least two electrode pairs wherein the anode and cathode of each said electrode pair are arranged on respective faces of said membrane. An electrode of each pair of electrodes is connected to an electrode of an adjacent pair of electrodes by a through-membrane connection (13) or by an external connection on a Printed Circuit Board, comprising an electrically conductive region of said electrolyte material. A method for forming the through-membrane electrical connections in the electrolyte membrane is also disclosed.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: April 24, 2018
    Assignees: Imperial Innovations Limited, UCL Business PLC
    Inventors: Daniel John Leslie Brett, Anthony Robert John Kucernak
  • Patent number: 9950355
    Abstract: Method of forming a component of complex shape from an Al-alloy sheet or a Mg-alloy sheet. The method includes the steps of: a) heating the sheet to a temperature below the solution heat treatment (SHT) temperature for the alloy; b) forming the heated sheet between heated dies into or towards the complex shape; c) heating the sheet to at least its SHT temperature and substantially maintaining that temperature until SHT has been completed; and d) quenching the solution heat treated sheet between cold dies and at the same time completing the forming into the complex shape or maintaining that shape.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: April 24, 2018
    Assignee: Imperial Innovations Limited
    Inventors: Jianguo Lin, Daniel Balint, Lilang Wang, Trevor Anthony Dean, Alistair David Foster
  • Patent number: 9944687
    Abstract: Peptide containing sequence from both the GLP-1 peptide and glucagon peptide, compositions comprising said peptides and methods of using said peptides for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as obesity or diabetes, are provided.
    Type: Grant
    Filed: July 4, 2011
    Date of Patent: April 17, 2018
    Assignee: Imperial Innovations Limited
    Inventor: Stephen Robert Bloom
  • Patent number: 9943840
    Abstract: This invention relates to a process for the preparation of surface-functionalised metal oxide, metal sulphide, metal selenide or metal telluride nanoparticles, a process for the preparation of a composite material comprising such nanoparticles, nanoparticles and a composite material produced thereby, the use of such nanoparticles in catalysis and a catalyst comprising such nanoparticles.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: April 17, 2018
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Milo Shaffer, Charlotte Williams, Katherine Orchard, Neil John Brown, Jonathan Weiner
  • Patent number: 9932317
    Abstract: This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prophylactic effect.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: April 3, 2018
    Assignees: Imperial Innovations Limited, Emory University
    Inventors: Robert Brown, Matthew John Fuchter, Nadine Chapman-Rothe, Nitipol Srimongkolpithak, Joachim Caron, James Snyder, Thota Ganesh, Jin Liu, Aiming Sun
  • Patent number: 9932344
    Abstract: Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are disclosed. Pharmaceutical compositions comprising these compounds, and the use of these compounds and compositions to inhibit CDK; to treat disorders associated with CDK such as those arising from an inappropriate activity, mutation, overexpression, or upstream pathway activation of CDK; or disorders that are ameliorated by the inhibition of CDK; proliferative disorders; cancer; viral infections; neurodegenerative disorders; ischaemia; renal diseases; and cardiovascular disorders are also disclosed. Optionally, the treatment further comprises simultaneous or sequential treatment with a further active agent, e.g., an aromatase inhibitor, an anti-estrogen, a Her2 blocker, a cytotoxic chemotherapeutic agent, etc.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: April 3, 2018
    Assignees: Cancer Research Technology Limited, Imperial Innovations Limited, Emory University
    Inventors: Alexander Bondke, Sebastian Kroll, Anthony Barrett, Matthew Fuchter, Brian Slafer, Simak Ali, Charles Coombes, James Patrick Snyder
  • Patent number: D825066
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: August 7, 2018
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Jindong Liu, Guang-Zhong Yang