Patents Assigned to Indiana University Research and Technology Corporation
  • Publication number: 20210296106
    Abstract: Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.
    Type: Application
    Filed: September 19, 2017
    Publication date: September 23, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Nicholas Manicke, Chengsen Zhang
  • Patent number: 11124761
    Abstract: Embodiments of the current invention include a hydrogel formed from crosslinked polyethylene glycol into which acrylated glucose oxidase has been immobilized through crosslinking to the gel. These hydrogels can be used to create hypoxia under ambient conditions for at least 72 hours and can be used to create hypoxic gradients. These embodiments permit the study of cells under a variety of hypoxic conditions.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: September 21, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Chien-Chi Lin, Camron Scott Dawes, Heiko Konig
  • Patent number: 11127943
    Abstract: A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the membrane. The electrode, the membrane and the metal dendrite seeding material are positioned in an electrolyte matrix. At least one dendrite extends from the electrode toward the electrolyte permeable membrane combines with at least one dendrite extending from the dendrite seeding material.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 21, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Jian Xie
  • Patent number: 11098033
    Abstract: The present disclosure relates to certain compounds having binding affinity for Ku, and uses thereof. Specifically, the present disclosure relates to the use of Ku inhibitors as described herein in site-specific genome engineering technologies, including but not limited to CRISPR/Cas9, Zinc finger nuclease (ZFN), Transcription activator-like effector nuclease (TALEN), and meganuclease. The present disclosure also relates to kits useful for site-specific genome engineering that include at least one compound as described herein.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 24, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: John J Turchi, Navnath Gavande, Pamela S. Vandervere-Carozza
  • Publication number: 20210252308
    Abstract: Methods for directly measuring a patient's relative sensitivity to radiation therapy are provided. In particular, the methods provide for calculating a radiation sensitivity quotient for monocytes in culture. The methods can be incorporated into radiotherapy (RT) treatment planning systems, which are also provided. The methods can be used to optimize patient treatment plans, thereby developing patient-specific radiation treatment plans. Methods for treating a patient with radiotherapy with an optimized treatment plan are provided.
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Jian-Yue Jin, Wenhu Pi, Feng-Ming Kong, Weili Wang
  • Patent number: 11090560
    Abstract: A physical device interface for a virtual reality system is provided, comprising: a microprocessor board including a microprocessor, a plurality of control outputs, a first communication port and a second communication port; a plurality of receptacles configured to provide power to a corresponding plurality of physical devices; and a power board coupled to the plurality of control outputs and the plurality of receptacles, the power board including a plurality of channels controlled by the plurality of control outputs to provide power to the plurality of receptacles. The first communication port is configured to communicate with a computer for configuration of the interface and the second communication port is configured to communicate with another interface.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: August 17, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Chauncey Eugene Frend
  • Patent number: 11082447
    Abstract: A system comprising a processor in electrical communication with a network and a non-transitory memory having instructions that, in response to an execution by the processor, cause the processor to monitor a routing information base (“RIB”) of the network, identify a change in the RIB, calculate a probability of suspiciousness of the change in the RIB, and classify the change in the RIB based on a continuum of trust are disclosed. Methods of managing routers are also disclosed.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 3, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: L. Jean Camp
  • Patent number: 11067509
    Abstract: The present disclosure provides a method and system including a non-confocal microscope with an attached imaging fiber optic for direct and real time in-situ visualization of mammalian microscopic structures for diagnostic and therapeutic uses.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 20, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Hany Osman
  • Patent number: 11053290
    Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 6, 2021
    Assignees: Indiana University Research and Technology Corporation, The United States Government as Represented by the Department of Veterans Affair
    Inventors: Tarek Maurice Ashkar, Radmila Micanovic
  • Publication number: 20210195879
    Abstract: The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.
    Type: Application
    Filed: June 21, 2019
    Publication date: July 1, 2021
    Applicants: The Jackson Laboratory, Indiana University Research and Technology Corporation, Sage Bionetworks
    Inventors: Gareth Howell, Gregory Carter, Michael Sasner, Stacey Rizzo, Harriet Williams, Bruce Lamb, Paul Territo, Adrian Oblak, Ben Logsdon, Lara Mangravite, Leah Graham
  • Patent number: 11047009
    Abstract: Biomarkers and methods for screening expression levels of the biomarkers for predicting and tracking suicidality, as well as for monitoring response to a treatment for suicidal risk and for determining suicidal risk as a side-effect of an antidepressant are disclosed.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: June 29, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Alexander B. Niculescu
  • Publication number: 20210145827
    Abstract: Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 20, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Ghaeth H. Yassen, Jeffrey A. Platt, Richard L. Gregory
  • Publication number: 20210139920
    Abstract: Embodiments disclosed herein provide compositions, methods, and uses for solubility-enhancing protein (SEP) tags. Certain embodiments provide expression vectors for the production of a soluble protein or polypeptide of interest (i.e., a target protein) having a molecular mass of about 100 kDa or greater. In some embodiments, the SEP tags enable expression of large and often difficult to express proteins, with yields appropriate for further protein study. Also described are nucleic acid cassettes that include a SEP tag, and fusion proteins expressed from the SEP expression vectors or nucleic acid cassettes. Kits including SEP expression vectors are also provided.
    Type: Application
    Filed: August 21, 2018
    Publication date: May 13, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Yuichiro Takagi, Tsuyoshi Imasaki
  • Patent number: 11002526
    Abstract: An XYZ flexural mechanism comprising an X-axis flexural mechanism comprising a first voice coil actuator, a motion stage platform, a plurality of flexural bearings, and a plurality of guide rods, a Y-axis flexural mechanism comprising a second voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, and a Z-axis flexural mechanism comprising a third voice coil actuator, a plurality of flexural bearings, a plurality of guide rods, and a frame, the frame supporting the XYZ flexural mechanism.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 11, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Hrishikesh Balasaheb Zambare, Ali Razban, Suhas Pandurang Deshmukh, Mahesh Shivaji Shewale, Sharad S. Mulik
  • Publication number: 20210128187
    Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Luke G. Gutwein, Rajiv Sood, Barry Davignon
  • Publication number: 20210132276
    Abstract: A polymer infrared polarizer (100) comprising a transparent polymer substrate (110) formed of a high sulfur content polymeric material, and a metal layer (130) fixed to an upper surface (120) of the transparent polymer substrate (110).
    Type: Application
    Filed: October 18, 2018
    Publication date: May 6, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Jong Eun Ryu
  • Patent number: 10991449
    Abstract: Biomarkers and methods for screening expression levels of the biomarkers for predicting suicidality (referred herein to suicidal ideation and actions, future hospitalizations and suicide completion) are disclosed. Also disclosed are quantitative questionnaires and mobile applications for assessing affective state and for assessing socio-demographic and psychological suicide risk factors, and their use to compute scores that can predict suicidality. Finally, an algorithm that combines biomarkers and computer apps for identifying subjects who are at risk for committing suicide is disclosed, as well as methods to mitigate and prevent suicidality based on the biomarkers and computer apps.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 27, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Alexander Bogdan Niculescu
  • Patent number: 10980985
    Abstract: The invention provides a catheter and control box apparatus and related methods that are useful in delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the invention provides a catheter that stabilizes fluid flow within a vein to deliver a volume, pressure charge of saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The catheter and control box apparatus and related methods described herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: April 20, 2021
    Assignees: Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans Affairs
    Inventor: Robert Bacallao
  • Patent number: 10968211
    Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 6, 2021
    Assignees: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: William W. Turner, Jr., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
  • Publication number: 20210076647
    Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ?GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.
    Type: Application
    Filed: April 22, 2020
    Publication date: March 18, 2021
    Applicant: Indiana University Research and Technology Corporation
    Inventor: A. Joseph Tector