Patents Assigned to Indiana University Research and Technology Corporation
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Patent number: 11672628Abstract: A modular mouthpiece for soft tissue placement includes a base tray and soft tissue placement inserts. The soft tissue placement inserts are configured to be selectively coupled to the base tray.Type: GrantFiled: September 10, 2020Date of Patent: June 13, 2023Assignee: Indiana University Research and Technology CorporationInventors: Timothy L. Nisi, Brian D. Overshiner
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Patent number: 11666039Abstract: The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ?GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are also provided. Methods of making and using the GT/CMAH-KO pigs and tissue are also provided.Type: GrantFiled: April 22, 2020Date of Patent: June 6, 2023Assignee: Indiana University Research and Technology CorporationInventor: A. Joseph Tector
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Patent number: 11660270Abstract: Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.Type: GrantFiled: July 20, 2018Date of Patent: May 30, 2023Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.Inventors: Domb Abraham Jacob, Michael Kubek
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Patent number: 11654229Abstract: A wound irrigation device including a container with an opening along the outer surface of the container and a nozzle assembly coupled to the container and configured to selectively allow the liquid to exit the container when pressure is applied to the container.Type: GrantFiled: March 17, 2017Date of Patent: May 23, 2023Assignee: Indiana University Research and Technology CorporationInventor: Brian Sloan
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Patent number: 11648226Abstract: Combination therapies including a Apurinic/Apyrimidinic Endonuclease/reduction-oxidation (redox) Factor-1 (APE1/Ref-1) inhibitor specific to inhibit the redox function of APE1/Ref-1 are disclosed herein. The Combination therapies can be used for treating various cancers, as well as other angiogenesis-mediated diseases (e.g., retinal diseases, cardiovascular diseases).Type: GrantFiled: September 21, 2020Date of Patent: May 16, 2023Assignee: Indiana University Research and Technology CorporationInventors: Mark R. Kelley, Melissa L. Fishel
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Patent number: 11633730Abstract: The present invention relates generally to an apparatus that is able to provide a sealed chamber system including a cell sorter, that allows for various oxygen tensions of choice to be maintained during cell harvest, sorting (and isolation of sub-populations of cells), analysis, etc.Type: GrantFiled: August 22, 2018Date of Patent: April 25, 2023Assignee: Indiana University Research and Technology CorporationInventor: Heather O'Leary
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Patent number: 11608532Abstract: The present disclosure relates generally to discovery of novel compounds involved in the treatment and prevention of suicidality by bioinformatics drug repurposing using novel genes expression biomarkers involved in suicidality. Disclosed are methods for assessing severity, determining future risk, matching with a drug treatment, and measuring response to treatment, for suicidality. Also disclosed are new methods of use for drugs and natural compounds repurposed for use in preventing and treating suicidality. These methods include computer-assisted methods analyzing the expression of panels of genes, clinical measures, and drug databases. Detailed herein are methods using a universal approach, in everybody, as well as personalized approaches by gender, and by diagnosis.Type: GrantFiled: November 7, 2019Date of Patent: March 21, 2023Assignees: Indiana University Research and Technology Corporation, The United States Government as Reprecented by the Department of Veterans AffairsInventor: Alexander Bogdan Niculescu
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Patent number: 11596783Abstract: Methods and devices for a self-contained device including a hydraulic motor and a hydraulic pump. Preferably, the motor is incorporated either within the interior of the pump, on the exterior of the pump, or a combination of the two. The pump increases the kinetic energy of the fluid by centrifugal means, and in some embodiments is a viscous impeller pump. Applications include building flow systems, industrial processes, and biological circulatory systems.Type: GrantFiled: March 6, 2019Date of Patent: March 7, 2023Assignee: Indiana University Research & Technology CorporationInventor: Mark D. Rodefeld
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Publication number: 20230049180Abstract: The present invention provides methods and materials useful delivering liquids, including liquids comprising nucleic acid molecules into cells. In particular, the present invention provides methods for delivering saline solution, exogenous compositions, and isolated vectors to kidney cells, using the renal vein as a guide and under hydrodynamic pressure. The delivery methods and materials herein are useful to research, prognose, ameliorate symptoms of kidney injury, and treat kidney pathologies.Type: ApplicationFiled: July 7, 2022Publication date: February 16, 2023Applicants: Indiana University Research & Technology Corporation, United States Government as Represented by the Department of Veterans AffairsInventors: Robert BACALLAO, Simon ATKINSON, George RHODES, Peter CORRIDON
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Patent number: 11581175Abstract: Mass spectrometry cartridge including a base in mechanical communication with a spray substrate holder, an absorbent pad between the base and the spray substrate holder, a translatable sample well holder interposed between the spray substrate holder and a top cover, the top cover configured to house a conductive element, wherein when the translatable sample well holder is in a first position, the translatable well holder is vertically above the absorbent pad, when the translatable sample well holder is in a second position, the translatable well holder is vertically above a spray substrate are disclosed. Methods of analyzing a sample are also disclosed.Type: GrantFiled: September 19, 2017Date of Patent: February 14, 2023Assignee: Indiana University Research and Technology CorporationInventors: Nicholas Manicke, Chengsen Zhang
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Publication number: 20230044112Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: January 4, 2021Publication date: February 9, 2023Applicants: Assembly Biosciences, Inc., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: William W. Turner, JR., Lee D. Arnold, Hans Maag, Leping Li, Mark G. Bures, Simon Nicolas Haydar, Samson Francis
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Publication number: 20230022700Abstract: Described herein are expression vectors encoding the Wolbachia protein WalE1. Also described are insects transformed with an expression vector of the present disclosure, and progeny thereof. Also described are methods for improving Wolbachia replication and transmission in its insect host by overexpressing WalE1 in the insect host. Improved Wolbachia replication and transmission provides for insect population control and pathogen resistance in insects, which can reduce disease transmission.Type: ApplicationFiled: July 14, 2021Publication date: January 26, 2023Applicant: Indiana University Research and Technology CorporationInventor: Irene Newton
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Publication number: 20230019129Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.Type: ApplicationFiled: January 21, 2021Publication date: January 19, 2023Applicants: Indiana University Research and Technology Corporation, Assembly Biosciences, Inc.Inventors: William W. Turner, JR., Lee Daniel Arnold, Hans Maag, Adam Zlotnick
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Patent number: 11535856Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.Type: GrantFiled: July 6, 2020Date of Patent: December 27, 2022Assignees: ARKANSAS STATE UNIVERSITY—JONESBORO, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
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Patent number: 11534362Abstract: A manually-operated quantification soft tissue mobilization (QSTM) device includes a pressure applicator and a sensor member. The pressure applicator is configured to enable a user to dynamically apply a stroking mechanical force as the pressure applicator is moved over an area treatment areas of a patient's soft tissue. The sensor member including an accelerometer and a gyrometer is configured to determine various parameters of the dynamically applied stroking mechanical force in three dimensions as the pressure applicator is moved over the treatment areas of the patient's soft tissue. These parameters include a force magnitude in three dimensions, an angle in multiple axes, a stroke position, a stroke frequency, a sensed vibration magnitude at dominant spectral frequencies, and/or a rate of the stroking mechanical force dynamically applied to the soft tissue.Type: GrantFiled: September 16, 2016Date of Patent: December 27, 2022Assignee: Indiana University Research and Technology CorporationInventors: Mary T. Loghmani, Sohel Anwar, Ahmed Alotaibi, Keith L. March, Stanley Chien
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Patent number: 11522425Abstract: A motor is provided, and includes: a stator having a plurality of electromagnets and a plurality of rolling elements arranged around the electromagnets; a rotor having a plurality of rotor traction components arranged to engage the plurality of rolling elements; and a control circuit; wherein the plurality of rolling elements are arranged relative to the plurality of rotor traction components to form a gap between the plurality of rolling elements and the plurality of rotor traction components; wherein the control circuit is configured to activate the plurality of electromagnets to cause the rotor to pivot about a pivot point defined in a spherical bearing and change the gap such that the rotor compresses against the stator and the plurality of rolling elements and the plurality of rotor traction components translate the compression into tangential thrust and rotation of the rotor.Type: GrantFiled: October 25, 2018Date of Patent: December 6, 2022Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventor: Matthew J. Rubin
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Patent number: 11491147Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway.Type: GrantFiled: October 3, 2017Date of Patent: November 8, 2022Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Jian-Ting Zhang, Jian-Yuan Liu
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Publication number: 20220346380Abstract: The present invention provides a novel class of insecticides for control of disease vector insects, particularly mosquitoes. These insecticides prevent maturation or development of larvae into adult insects using interfering RNA (iRNA). The present invention further includes compositions comprising iRNA and methods of controlling, reducing, or treating an insect infestation with the iRNA or compositions described herein.Type: ApplicationFiled: January 7, 2022Publication date: November 3, 2022Applicants: Indiana University Research and Technology Corporation, University of Notre Dame du LacInventors: Molly Duman Scheel, David W. Severson, Kathleen Eggleson, Na Wei
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Patent number: 11479752Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.Type: GrantFiled: October 17, 2018Date of Patent: October 25, 2022Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventor: Burcin Ekser
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Patent number: 11460861Abstract: A method of controlling an operation of a robot (102) is provided using a cluster of nodes (104) in a network (106). The method includes receiving, using a gateway cloud driver (108), robot state information from the robot (102) via the network (106), and converting, using the gateway cloud driver (108), the robot state information into at least one message. The method further includes transmitting, using a message broker (110), the at least one message to the cluster of nodes (104) via the network (106). The method further includes processing, using the cluster of nodes (104) in the network (106), the at least one message by parallel computing, and generating, using the cluster of nodes (104) in the network (106), a robot command to control the operation of the robot (102).Type: GrantFiled: February 16, 2018Date of Patent: October 4, 2022Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Geoffrey C. Fox, Supun M. Kamburugamuve Loku Acharige