Patents Assigned to Institut National de Recherche Pour L'Agriculture, L'Alimentation et L'Environnement
  • Patent number: 12011466
    Abstract: The invention relates to the field of modified Escherichia coli strain Nissle 1917 (EcN) and its use for treating gastro-intestinal disorders. The invention is based on the study of the mechanisms implicated in the probiotic properties of the Escherichia coli strain Nissle 1917 (EcN). This study has allowed the inventors to decouple the probiotic activity of EcN from its genotoxic activity by demonstrating that EcN ClbP protein, the enzyme that activates the genotoxin colibactin, is also required for the siderophore-microcins activity of probiotic EcN, but interestingly, not its enzymatic domain that cleaves precolibactin to form active colibactin.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: June 18, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PAUL SABATIER TOULOUSE III, ECOLE NATIONALE VÉTÉRINAIRE DE TOULOUSE, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Eric Oswald, Jean-Philippe Nougayrede, Clémence Massip, Patricia Martin, Priscilla Branchu
  • Patent number: 11981750
    Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: May 14, 2024
    Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: John P. Bannantine, Gilles Etienne, Sylvie Bay, Franck Biet
  • Patent number: 11912645
    Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 27, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, ECOLE NATIONALE VETERINAIRE DE TOULOUSE, UNIVERSITE PAUL SABATIER TOULOUSE III, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE DE MONTPELLIER, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
    Inventors: Nicolas Cenac, Justine Bertrand-Michel, Teresa Perez-Berezo, Thierry Durand, Jean-Marie Galano, Julien Pujo, Eric Oswald, Patricia Martin, Pauline Le Faouder, Alexandre Guy
  • Patent number: 11898151
    Abstract: The present invention relates to a plant obtained by mutagenesis, such that the expression and/or the activity of the ESK1 protein and the expression and/or the activity of the TPS7 protein are diminished compared to a non-mutagenated plant. Said plant with biomass that has better digestibility maintains satisfactory growth. A further aim of the present invention is a method for preparing said plant, as well as the use of said plant for the production of biofuel.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: February 13, 2024
    Assignee: Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement
    Inventors: Christine Horlow, Marie-Hélène Durand-Tardif, Gregory Mouille, Peter Rogowsky
  • Patent number: 11882822
    Abstract: The present invention relates to a system for spraying a product, notably a plant-protection product, comprising product spray nozzles (10) and airflow generating means (110), characterized in that the airflow generating means comprise an outlet (112) in the form of an annular slit designed to generate an airflow (102) in the form of a continuous tubular curtain of air enclosing the jets (12) emanating from the spray nozzles (10) and that the sprayed product cannot cross.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: January 30, 2024
    Assignee: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Vincent De Rudnicki, Jean-Francois Bonicel, Raphael Cherfan
  • Publication number: 20240026388
    Abstract: The subject of the invention is a process for treating lignocellulosic biomass comprising the following steps: a) conditioning the lignocellulosic biomass, b) washing said particles, c) separating the aqueous solution from the washed biomass particles, d) impregnating said lignocellulosic substrate with an acid liquor, e) carrying out a solid/liquid separation of the impregnated lignocellulosic substrate, f) pretreating said substrate from step e) by cooking, g) carrying out an enzymatic hydrolysis of the pretreated lignocellulosic substrate, h) carrying out a fermentation of the hydrolyzate from step g), and introducing the used aqueous washing solution into a step of said biomass treatment process which is after the pretreatment step f), and/or into an enzyme production step and/or into a step of producing/propagating the microorganisms necessary for steps g) or h).
    Type: Application
    Filed: January 20, 2020
    Publication date: January 25, 2024
    Applicants: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT, IFP Energies Nouvelles
    Inventors: Caroline AYMARD, Severine LOUESDON-JEUNET, Romain ROUSSET, Damien HUDEBINE
  • Publication number: 20230372416
    Abstract: A combination of agents capable of binding an infectious agent, such as an antibody, an antibody derivative, or an antibody mimetic, and immunomodulatory agents, such as probiotic strains, for the treatment or prevention of respiratory infections, in particular bacterial respiratory infections. The agents capable of binding an infectious agent are administered by inhalation.
    Type: Application
    Filed: October 8, 2021
    Publication date: November 23, 2023
    Applicants: UNIVERSITÉ DE TOURS, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Nathalie HEUZE-VOURC'H, Thomas SECHER, Muriel THOMAS
  • Publication number: 20230323385
    Abstract: The present invention relates to novel plants displaying an improved resistance to nematodes. The present invention also relates to seeds and parts of said plants. The present invention further relates to methods of making and using such seeds and plants. The present invention also relates to a novel SmD1 allele, which results in a modified SmD1 protein associated with such improved resistance to nematodes.
    Type: Application
    Filed: March 29, 2021
    Publication date: October 12, 2023
    Applicants: SYNGENTA CROP PROTECTION AG, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITÉ COTE D'AZUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Michaël Quentin, Bruno Favery, Gregori Bonnet, Joffrey Mejias, Nhat-My Truong, Pierre Abad
  • Publication number: 20230295679
    Abstract: The present invention relates to a process for preparing an alkyl polyglucoside by enzymatic catalysis, using sucrose or an analogue thereof as substrate and making it possible to obtain a large diversity of alkyl polyglucosides in terms of size and structure of the glucoside part thereof, making possible the obtaining of an alkyl polyglucoside with a number of glucosyl units that can be adjusted from 2 to 200 glucosyl units. The process also makes it possible to adjust the linear or branched structure of the carbohydrate part of the alkyl polyglucoside obtained, and also the nature of the glycosidic bonds linking the glucose residues within the carbohydrate part.
    Type: Application
    Filed: July 2, 2021
    Publication date: September 21, 2023
    Applicants: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, Institut National de Recherche Pour l'Agriculture, l'Alimentation et l'Environnement, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Etienne SEVERAC, Claire MOULIS, David GUIEYSSE, Sandrine MOREL, Magali REMAUD-SIMEON
  • Publication number: 20230172201
    Abstract: The present invention relates to the use of 2-phenylbutyric acid, or 3-phenylbutyric acid, or 4-phenylbutyric acid, or one of their salts, or one of their combinations, to combat cryptogamic diseases caused by fungi and oomycetes. The present invention also relates to the use of these compounds and these combinations as fungicidal or fungistatic agents for the prevention or the curative treatment of cryptogamic diseases.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 8, 2023
    Applicants: Institut National de Recherche Pour L'Agriculture, L'Alimentation et L'Environnement, Institut des Sciences et Industries du Vivant et de L'Envirinnement, Centre National de la Recherche Scientifique, Universite de Bourgogne, Université Bourgogne -Franche-Comté, Institut National Superieur des Sciences Agronomiques de l'Alimentation et de l'Environnement
    Inventors: Jean-Luc Cacas, Damien Vasselon, Olivier Lamotte, Benoît Poinssot, Anne-Sophie Walker
  • Publication number: 20230101904
    Abstract: The present invention relates to a bacterium, in which the expression and/or the activity of surface proteases is/are inhibited, to its preparation process and to the uses of this bacterium.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 30, 2023
    Applicants: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES ET INDUSTRIES DU VIVANT ET DE L'ENVIRONNEMENT
    Inventors: Vincent Juillard, Rozenn Gardan, Mylène Boulay, Véronique Monnet
  • Patent number: 11609221
    Abstract: The invention relates to an autonomous method for the online evaluation of the toxicity of aqueous solutions by analysis of the locomotor behavior of small-sized aquatic benthic macroinvertebrates (0.1 cm-5 cm) maintained in the lethargic state.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: March 21, 2023
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, VIEW POINT
    Inventors: Arnaud Chaumot, Maxime Dauphin, Alexandre Decamps, Olivier Geffard, Florian Moulin, Didier Neuzeret, Hervé Queau
  • Patent number: 11471498
    Abstract: The present disclosure relates to a new probiotic strain of Lactobacillus brevis, isolated from pulque and exhibiting anti-cancer properties, as well as to compositions which contain said strain.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: October 18, 2022
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUTO POLITECNICO NACIONAL (IPN)
    Inventors: Luis Bermudez Humaran, Edgar Torres Maravilla, Philippe Langella, Maria Elena Sanchez-Pardo
  • Patent number: 11457643
    Abstract: Disclosed is a method for manufacturing a cheese-based food product, advantageously a cheese, cheese specialty, or cheese substitute, the method including: a) a step A) of providing at least one flavoring matrix, the consistency of which ranges from liquid to pasty, the flavoring matrix resulting from a step of cultivating at least one flavor producing microorganism in a culture medium, the step A) also providing a texture matrix, the consistency of which ranges from liquid to pasty, the texture matrix being suitable for providing the texture of the food product; then b) a step B) of mixing the at least one flavoring matrix with the at least one texture matrix; then c) a texturing step C), during which the mixture from mixing step B is subjected to physiochemical texturing conditions that are adjusted according to the final texture sought for the cheese-based food product.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: October 4, 2022
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT SUPERIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE
    Inventors: Gilles Garric, Joelle Leonil, Romain Jeantet, Frederic Gaucheron, Pierre Schuck, Sylvie Lortal
  • Publication number: 20220233607
    Abstract: A strain of an Apicomplexa of the family Sarcocystidae, wherein the strain is replicative and expresses one or more heterologous protein(s) selected from the group including therapeutic proteins, antigens, recombinant surface receptor or combinations thereof, and wherein the strain is selected from the group including Toxoplasma gondii and Neospora caninium. Also, the use of the strain for preventing or treating cancers or infectious diseases in a subject in need thereof.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 28, 2022
    Applicants: UNIVERSITÉ DE TOURS, KYMERIS THERAPEUTICS INC., INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L' ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Isabelle DIMIER-POISSON, Marie-Noëlle MEVELEC, Anne DI TOMMASO, Nicolas AUBREY, Louis LANTIER, Gordon LEE
  • Patent number: 11344586
    Abstract: The present invention provides methods for determining if a patient is likely to benefit from a cancer treatment, by determining if said patient has a gut dysbiosis with an over representation of certain bacterial species. The present invention also provides probiotic strains to improve the efficacy of a cancer treatment, especially chemotherapy, in patients in need thereof.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: May 31, 2022
    Assignees: INSTITUT GUSTAVE ROUSSY, UNIVERSITE PARIS-SACLAY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Laurence Zitvogel, Ivo Gomperts Boneca, Patricia Lepage, Sophie Viaud, Romain Daillere
  • Patent number: 11337440
    Abstract: A method for producing an assembly of at least one dairy protein and at least one vegetable protein, and the assembly obtained by the method. Also, the uses of the assembly, in particular in the food processing field.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: May 24, 2022
    Assignees: ROQUETTE FRERES, INGREDIA, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Bernard Boursier, Emmanuelle Moretti, Guillaume Ribadeau-Dumas, Saliha Belaid, Alain Riaublanc, Jacques Gueguen, Anne Lepoudere, Jean-Jacques Snappe, Isabelle Colin
  • Patent number: 11332600
    Abstract: Disclosed is a method for producing nanocelluloses from a cellulose substrate including cellulose fibers, the method including the following sequence of steps: —a step of enzymatic treatment of the cellulose substrate, by bringing same into contact with at least one cleaving enzyme, then—a step of mechanical treatment of the cellulose substrate subjected to the step of enzymatic treatment, in order to delaminate the cellulose fibres and obtain the nanocelluloses. The at least one cleaving enzyme is chosen from the enzymes belonging to the family of lytic polysaccharide monooxygenases (LPMOs) capable of achieving cleavage in the presence of an electron donor. Also disclosed are the nanocelluloses obtained according to the method.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 17, 2022
    Assignee: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Bernard Cathala, Ana Villares, Jean-Guy Berrin, Celine Moreau
  • Publication number: 20220143070
    Abstract: A nutraceutical composition including one or more sources of fiber, glutamine, one or more probiotics, one or more sources of omega-3, and one or more antioxidants, for use in the prevention and/or treatment of dysbiosis of the intestinal microbiota. Also, a method for preventing and/or treating dysbiosis including a step of administering the nutraceutical composition to a patient in need thereof. Further, a three-part kit for use in the prevention and/or treatment of dysbiosis of the intestinal microbiota.
    Type: Application
    Filed: March 5, 2020
    Publication date: May 12, 2022
    Applicants: MATIVA TECH, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Hélène DUMINY, Alain VERNEAU, Luc HEITZ, Joël DORÉ
  • Patent number: PP35386
    Abstract: A sweet cherry tree named ‘Denfer’ distinguished by its regular production of firm uniform fruit with good acid to sugar balance.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: September 19, 2023
    Assignee: INRAE Institut National de Recherche pour l'agriculture, l'alimentation et l'environnement
    Inventor: Jose Quero Garcia