Patents Assigned to Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences
  • Patent number: 10035771
    Abstract: The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: July 31, 2018
    Assignee: INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PR CHINA
    Inventors: Hui Wang, Wannian Zhng, Zhenyuan Miao, Tao Li, Xiong Liu, Yuelin Wu, Sen Luo, Chunquan Sheng, Xiaoxue Lu, Jianzhong Yao
  • Publication number: 20160083347
    Abstract: The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.
    Type: Application
    Filed: May 19, 2014
    Publication date: March 24, 2016
    Applicants: INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PR CHINA, THE SECOND MILITARY MEDICAL UNIVERSITY
    Inventors: Hui WANG, Wannian ZHNG, Zhenyuan MIAO, Tao LI, Xiong LIU, Yuelin WU, Sen LUO, Chunquan SHENG, Xiaoxue LU, Jianzhong YAO
  • Patent number: 8946384
    Abstract: The present invention provides a polypeptide TF1 for inhibiting type-2 Shiga-toxin activity, an encoding gene for the same and use thereof. The present polypeptide is named TF1 (also known as P1); its amino acid sequence is shown in SEQ ID NO: 1 in the sequence list. The polypeptide P1 can be prepared into medicine for preventing and/or treating diseases caused by type-2 Shiga toxin or the pathogens which produce type-2 Shiga toxin.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: February 3, 2015
    Assignee: Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, PR China
    Inventors: Hui Wang, Tao Li, Qin Wang, Wei Tu, Xiaojun Hou, Yuenan Liu, Jing Shi, Kun Cai
  • Publication number: 20130210750
    Abstract: The present invention provides a polypeptide TF1 for inhibiting type-2 Shiga-toxin activity, an encoding gene for the same and use thereof. The present polypeptide is named TF1 (also known as P1); its amino acid sequence is shown in Sequence 1 in the sequence list. The polypeptide P1 can be prepared into medicine for preventing and/or treating diseases caused by type-2 Shiga toxin or the pathogens which produce type-2 Shiga toxin.
    Type: Application
    Filed: September 9, 2011
    Publication date: August 15, 2013
    Applicant: Institute of Microbiology and Epidemiology Academy of Military Medical Sciences
    Inventors: Hui Wang, Tao Li, Qin Wang, Wei Tu, Xiaojun Hou
  • Publication number: 20130157380
    Abstract: A multiassay immunochromatographic chip comprises: a viscous bottom lining (1), a sample pad (2), a bonding pad (3), an analysis membrane (4) and a water absorption pad (5). The bonding pad (3) fixedly has a plurality of assay binding substances (6) and a control binding substance (7), the assay binding substance (6) is formed by joining a tracer (8) and a liquid-phase detection probe (9), the control binding substance (7) is formed by joining the tracer (8) and a liquid-phase control probe (11); the analysis membrane (4) is provided with a detection matrix unit (12), each detection matrix unit comprises a detection zone (13) and a control zone (14), wherein the detection zone (13) consists of a plurality of solid phase detection probes (15) and the control zone (14) consists of a solid phase control probe (16). Organic integration of immunochromatographic reaction modes and chip assay matrix settings enables high throughput assay of multiple target substances with one sample load.
    Type: Application
    Filed: August 18, 2011
    Publication date: June 20, 2013
    Applicant: INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA
    Inventors: Lei Zhou, Zhaobiao Guo, Ruifu Yang
  • Publication number: 20100120173
    Abstract: Provided is a strip-assembled immunochromatographic disc, containing: a base, a lid engaged with the base and a draining piece disposed between the strips on the base and the lid, wherein a sampling opening is disposed on the lid directly facing to the draining piece, and the said sampling opening intercommunicates to a draining groove provided on the inner side of the lid which is formed by a plurality of draining channels; several strip stages are provided on the base with their location and number corresponding to those of the draining channels provided on the lid, and the edge of the draining piece laps to the sample pads of the strips carried on the stage adjacent to one end of the sampling opening. Also provided is a method of performing multiplexed immnochromatographic detection using the strip disc to accomplish the detection of multiple target analytes in one sample in an assay.
    Type: Application
    Filed: April 23, 2007
    Publication date: May 13, 2010
    Applicant: Institute of Microbiology and Epidemiology, Academy of Military Medical Science
    Inventors: Lei Zhou, Zongmin Du, Ruifu Yang, Huijie Huang
  • Patent number: 5677331
    Abstract: The invention relates to a synergistic antimalarial composition which comprises the antimalarial agent benflumetol and also an antimalarial agent from the artemisinine group such as artemether. The composition can be formulated into solid dosage forms such as tablets and is useful for the treatment of drug resistant malaria.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: October 14, 1997
    Assignees: Ciba-Geigy AG, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences
    Inventors: Yiqing Zhou, Dianxi Ning, Shufen Wang, Deben Ding, Guofu Li, Chengqi Shan, Guangyu Liu