Patents Assigned to Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, PR China
  • Mercaptonicotinic acid compound and preparation method and use thereof
    Patent number: 10035771
    Abstract: The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: July 31, 2018
    Assignee: INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PR CHINA
    Inventors: Hui Wang, Wannian Zhng, Zhenyuan Miao, Tao Li, Xiong Liu, Yuelin Wu, Sen Luo, Chunquan Sheng, Xiaoxue Lu, Jianzhong Yao
  • MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20160083347
    Abstract: The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound could inhibit activity of botulinum toxin endopeptidase and tetanus toxin endopeptidase in vitro, which has a significant protective effect on botulinum toxin poisoning in mice, and can be used for preparing medicine intended to prevent and/or treat botulism, as well as to prevent botulinum toxin exposure and tetanus.
    Type: Application
    Filed: May 19, 2014
    Publication date: March 24, 2016
    Applicants: INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES, PR CHINA, THE SECOND MILITARY MEDICAL UNIVERSITY
    Inventors: Hui WANG, Wannian ZHNG, Zhenyuan MIAO, Tao LI, Xiong LIU, Yuelin WU, Sen LUO, Chunquan SHENG, Xiaoxue LU, Jianzhong YAO
  • Polypeptide TF1 for inhibiting type 2 Shiga toxin activity, encoding gene for same and use thereof
    Patent number: 8946384
    Abstract: The present invention provides a polypeptide TF1 for inhibiting type-2 Shiga-toxin activity, an encoding gene for the same and use thereof. The present polypeptide is named TF1 (also known as P1); its amino acid sequence is shown in SEQ ID NO: 1 in the sequence list. The polypeptide P1 can be prepared into medicine for preventing and/or treating diseases caused by type-2 Shiga toxin or the pathogens which produce type-2 Shiga toxin.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: February 3, 2015
    Assignee: Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, PR China
    Inventors: Hui Wang, Tao Li, Qin Wang, Wei Tu, Xiaojun Hou, Yuenan Liu, Jing Shi, Kun Cai