Patents Assigned to Institute of Molecular Biology, Inc.
  • Nerve regeneration
    Patent number: 6506727
    Abstract: It has been found that the growth factor PDGF, when used in combination with another growth factor such as IGF-I, acts synergistically with the other factor to promote neuronal regeneration.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: January 14, 2003
    Assignee: Institute of Molecular Biology, Inc.
    Inventors: Hans-Arne Hansson, Samuel E. Lynch, Harry N. Antoniades
  • Device to promote drug-induced nerve regeneration
    Patent number: 5656605
    Abstract: The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve; (2) guiding filaments disposed within the guide tube; and, (3) a therapeutic composition enclosed by the guide tube. Both the guide tube and the guiding filaments are composed of biologically compatible materials, while the therapeutic composition contains a nerve-growth-stimulating agent dispersed in a matrix-forming material. During treatment, the guide tube is inserted between the ends of lesioned nerves, resulting in the stimulation of axon growth.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: August 12, 1997
    Assignee: Institute of Molecular Biology, Inc.
    Inventors: Hans-Arne Hansson, Michael R. Wells, Samuel E. Lynch, Harry N. Antoniades
  • Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
    Patent number: 5516699
    Abstract: A method of diagnosing severity of periodontal disease or peri-implant disease in a human patient, involving a) obtaining a sample of tissue or gingival crevicular or other fluid from the mouth of said patient, or a blood or urine sample from the patient, and b) measuring a pyridinoline crosslinked compound in the sample as a measure of severity of disease.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: May 14, 1996
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: William V. Giannobile, Ray C. Williams, Samuel E. Lynch
  • Wound healing using IGF-II and TGF
    Patent number: 5256644
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-I and purified transforming growth factor beta.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: October 26, 1993
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Method for periodontal regeneration
    Patent number: 5124316
    Abstract: A method for promoting bone, periodontium or ligament growth of a mammal comprising applying to the bone periodontium or ligament a growth-promoting amount of a composition comprising a partially purified or purified polypeptide growth factor.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: June 23, 1992
    Assignees: President and Fellows of Harvard College, Institute of Molecular Biology, Inc.
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Process of wound healing using PDGF and EGF
    Patent number: 5034375
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified EGF and purified PDGF in a weight to weight ratio of at least 5:1.
    Type: Grant
    Filed: August 10, 1988
    Date of Patent: July 23, 1991
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound healing composition of IGF-I and TGF-.beta.
    Patent number: 4983581
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-1 and purified transforming growth factor beta.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: January 8, 1991
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound headling composition of TGF-alpha and PDGF
    Patent number: 4874746
    Abstract: Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified transforming growth factor alpha.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: October 17, 1989
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch