Patents Assigned to Instituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
  • Saturated bicyclic heterocyclic derivatives as SMO antagonists
    Patent number: 8470823
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: June 25, 2013
    Assignee: Instituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
    Inventors: Danila Branca, Federica Ferrigno, Jose Ignacio Martin Hernando, Philip Jones, Olaf Kinzel, Savina Malancona, Ester Muraglia, Maria Cecilia Palumbi, Giovanna Pescatore, Rita Scarpelli