Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
August 28, 2009
Date of Patent:
June 25, 2013
Instituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.
Danila Branca, Federica Ferrigno, Jose Ignacio Martin Hernando, Philip Jones, Olaf Kinzel, Savina Malancona, Ester Muraglia, Maria Cecilia Palumbi, Giovanna Pescatore, Rita Scarpelli