Patents Assigned to InterVet, Inc.
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Publication number: 20210077610Abstract: The present invention pertains to a vaccine to protect a pig against an infection with Actinobacillus pleuropneumoniae, the vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus, and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 19, 2018Publication date: March 18, 2021Applicant: Intervet Inc.Inventors: Maarten Hendrik Witvliet, Johanna Jacoba Elisabeth Bijlsma
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Publication number: 20210077729Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (SType: ApplicationFiled: March 26, 2019Publication date: March 18, 2021Applicant: Intervet Inc.Inventors: Frank Altermann, Daniel Seeh, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt
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Publication number: 20210069417Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10). The tensioning device (S) has a ramp (52) which is rotatable by means of a motor (12) and has a ramp track (53) extending along a helical line, wherein the ramp track (53) ascends from a first plateau along a region of inclination (S1, S2) to a second plateau and descends from the second plateau to the first plateau via a transition flank (46).Type: ApplicationFiled: March 26, 2019Publication date: March 11, 2021Applicant: Intervet Inc.Inventors: Frank Altermann, Dominic Kamenzin, Thomas Schmidt, Manuel Mattes, Robin Sauter, Daniel Seeh
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Publication number: 20210068375Abstract: The present invention pertains to a method for automatic sea lice monitoring in fish aquaculture, the method comprising submerging a camera (4) in a sea pen (300) comprising fish, using the camera to make an image of at least one of said fish, analysing the image to differentiate between individual sea lice present on the fish and the fish itself and assessing the number of sea lice present on the fish, wherein the camera is attached to a device (1, 10, 100) for guiding the salmon along an imaging track (5), the camera being directed to the track.Type: ApplicationFiled: November 18, 2020Publication date: March 11, 2021Applicant: Intervet Inc.Inventors: Peter Jans, Evert Gijtenbeek
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Publication number: 20210061775Abstract: This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.Type: ApplicationFiled: September 15, 2020Publication date: March 4, 2021Applicant: Intervet Inc.Inventors: Anja Regina Heckeroth, Jürgen Lutz, Christina Mertens, Heike Williams, Hartmut Zoller, Takeshi Mita
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Publication number: 20210052815Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (SType: ApplicationFiled: March 26, 2019Publication date: February 25, 2021Applicant: Intervet Inc.Inventors: Frank Altermann, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt, Daniel Seeh
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Patent number: 10927172Abstract: The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The invention also relates to use of these antibodies in the treatment of dogs.Type: GrantFiled: June 13, 2018Date of Patent: February 23, 2021Assignee: INTERVET INC.Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey, Leonard Presta
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Publication number: 20210040223Abstract: The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor ?. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.Type: ApplicationFiled: October 27, 2020Publication date: February 11, 2021Applicant: Intervet Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang
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Publication number: 20210030862Abstract: The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting pigs against an infection with Streptococcus suis of serotype 2 and against an infection with Streptococcus suis of serotype 9.Type: ApplicationFiled: December 14, 2018Publication date: February 4, 2021Applicant: Intervet Inc.Inventor: Antonius Arnoldus Christiaan Jacobs
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Publication number: 20210023303Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10).Type: ApplicationFiled: March 26, 2019Publication date: January 28, 2021Applicant: Intervet Inc.Inventors: Frank Altermann, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt, Daniel Seeh
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Publication number: 20200405692Abstract: The present invention relates to methods of treating demodicosis by administering an isoxazoline compound of formula (I)Type: ApplicationFiled: September 9, 2020Publication date: December 31, 2020Applicant: Intervet Inc.Inventors: Heike Williams, Anja Regina Heckeroth, Janina Tanzler, Regis Joel Alain Frenais
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Patent number: 10875847Abstract: The instant invention provides compounds of formula I which are selective JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as atopic dermatitis, arthritis, and cancer.Type: GrantFiled: December 13, 2017Date of Patent: December 29, 2020Assignee: Intervet Inc.Inventors: Peter H. Fuller, Jason Brubaker, Jonathan R. Young
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Publication number: 20200390748Abstract: Liquid veterinary pour-on or spot-on composition comprising at least one isoxazoline compound of formula (I) and a pharmaceutically acceptable carrier comprising at least one dermal penetration 5 enhancer comprising menthol and a solvent system comprising a pyrrolidone solvent are disclosed. Methods for using and administering such preparation in the prevention and control of parasite infestations in livestock animals are also disclosed.Type: ApplicationFiled: December 21, 2018Publication date: December 17, 2020Applicant: Intervet Inc.Inventors: John Gerard SHEEHAN, Keith FREEHAUF, Annie FLOCHLAY-SIGOGNAULT
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Publication number: 20200390712Abstract: The present invention pertains to a method for producing a medicinal product comprising a biologically active protein comprising the steps of providing an aqueous composition comprising a solvent, the biologically active protein and between 20% w/w and 60% w/w of a non-polymeric sugar, freezing the composition, thereby forming at least one frozen body comprising the solvent in frozen form, putting the frozen body in a drying apparatus while being carried by a support, the support comprising one or more restraining elements that define one or more boundaries of the support, wherein at most 30% of the surface of the body is contiguous with the one or more restraining elements, reducing the pressure in the drying apparatus below atmospheric pressure, providing heat to the body in order to sublimate the frozen solvent of the body and obtain a dried body. The invention also pertains to a product obtainable by this method.Type: ApplicationFiled: July 1, 2020Publication date: December 17, 2020Applicant: Intervet Inc.Inventors: Kevin O'Connell, Sandhya Buchanan
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Patent number: 10863727Abstract: The present invention pertains to a method for automatic sea lice monitoring in fish aquaculture, the method comprising submerging a camera (4) in a sea pen (300) comprising fish, using the camera to make an image of at least one of said fish, analysing the image to differentiate between individual sea lice present on the fish and the fish itself and assessing the number of sea lice present on the fish, wherein the camera is attached to a device (1, 10, 100) for guiding the salmon along an imaging track (5), the camera being directed to the track.Type: GrantFiled: October 21, 2016Date of Patent: December 15, 2020Assignee: Intervet Inc.Inventors: Peter Jans, Evert Gijtenbeek
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Patent number: 10864195Abstract: This invention provides topical localized formulations comprising an isoxazoline compound and a pharmaceutically or veterinary acceptable liquid carrier vehicle comprising N,N-diethyl-3-methylbenzamide as a solvent and an improved method for controlling, and preventing parasite infestation in animals.Type: GrantFiled: November 21, 2017Date of Patent: December 15, 2020Assignee: Intervet Inc.Inventors: Stefan Fuchs, Anja Regina Heckeroth, Ramona Müller, Heike Williams, Hartmut Zoller
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Publication number: 20200384102Abstract: The invention pertains to a vaccine comprising in combination non-replicating immunogens of Erysipelothrix rhusiopathiae, porcine parvo virus, Leptospira interrogans and live attenuated PRRS virus, and a pharmaceutically acceptable carrier, for use in a method for prophylactic treatment of a swine against an infection with Erysipelothrix rhusiopathiae, porcine parvo virus, Leptospira interrogans and PRRS virus, wherein the vaccine is administered in a single dose with regard to the treatment against an infection with PRRS virus.Type: ApplicationFiled: November 28, 2017Publication date: December 10, 2020Applicant: Intervet Inc.Inventors: Erwin Born van den, Antonius Arnoldus Christiaan Jacobs, Melanie Sno
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Patent number: 10858437Abstract: The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor ?. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.Type: GrantFiled: April 1, 2016Date of Patent: December 8, 2020Assignee: Intervet, Inc.Inventors: Mohamad Morsey, Yuanzheng Zhang
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Patent number: 10852286Abstract: The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine. The method allows the determination of the antigen content in a mixture additionally comprising antibodies that are capable of binding with the antigen.Type: GrantFiled: October 31, 2019Date of Patent: December 1, 2020Assignee: Intervet, Inc.Inventors: Michelle Allen, Mark Garrett, Urs Peter Bruderer, Martinus Antonius Johannes Thijssen
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Publication number: 20200368346Abstract: The present invention describes a liquid vaccine composition of a live enveloped virus and a pharmaceutically acceptable carrier, whereby the carrier is a natural deep-eutectic solvent (NADES), and the vaccine has a water activity of less than about 0.8. The NADES provides a stabilisation of the sensitive virus for prolonged time and at ambient temperature. In general, the liquid vaccine compositions according to the invention, in different compositions for the various enveloped viruses, show remarkable capabilities of stabilisation. This overcomes the need for lyophilisation, a great economic benefit. Also the liquid nature of the vaccines facilitates administration to human or animal targets.Type: ApplicationFiled: December 21, 2018Publication date: November 26, 2020Applicant: Intervet Inc.Inventors: Paul Vermeij, Edwin Kets, Chris Dirks, Martin Piest