Patents Assigned to Iowa State University Research Foundation, Inc.
  • Patent number: 10576093
    Abstract: The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 3, 2020
    Assignees: Iowa State University Research Foundation, Inc., The Medical College of Wisconsin, Inc.
    Inventors: Anumantha Kanthasamy, Balaraman Kalyanaraman
  • Patent number: 10577544
    Abstract: The present application discloses low temperature, low pressure methods (LTLP) for upgrading and/or stabilizing bio-oil or a bio-oil fraction. One method comprises providing a bio-oil or bio-oil fraction and hydrogen, which are reacted in the presence of a catalyst at a temperature of less than 150° C. and a pressure of less than 100 bar (absolute) to produce a hydrogenated liquid oil at a carbon yield of over 75%. Another method comprises providing a bio-oil or bio-oil fraction, providing oxygen reducing reaction conditions, and reacting the bio-oil or bio-oil fraction under the oxygen reducing reaction conditions at LTLP to produce an upgraded bio-oil product containing fewer carbonyls than the bio-oil or bio-oil fraction. Yet another method comprises providing a bio-oil or bio-oil fraction and a solution comprising one or more fermentation organisms and a sugar source. The solution and bio-oil or bio-oil fraction are combined to obtain a fermentation mixture, which is incubated at 15° C. to 30° C.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: March 3, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Marjorie Rover, Robert C. Brown, Patrick H. Hall, Ryan G. Smith
  • Patent number: 10570238
    Abstract: The present invention relates to a block copolymer comprising at least one PA block and at least one PB block. The PA block represents a polymer block comprising one or more units of monomer A, and the PB block represents a polymer block comprising one or more units of monomer B. Monomer A is a vinyl, acrylic, diolefin, nitrile, dinitrile, or acrylonitrile monomer. Monomer B is a radically polymerizable plant oil monomer containing one or more triglycerides. The present invention also relates to a method of preparing a thermoplastic block copolymer by radical polymerizing a radically polymerizable monomer with a radically polymerizable plant oil monomer containing one or more triglycerides, in the presence of an initiator and a transition-metal catalyst system to form the thermoplastic block copolymer. The polymerized plant oil-based block copolymers are useful in a variety of applications, such as asphalt modifiers, rubber compositions, adhesives, tires, in the automobile industry, footwear, packaging, etc.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: February 25, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Eric William Cochran, Ronald Christopher Williams, Nacu Hernandez, Andrew A. Cascione
  • Patent number: 10570286
    Abstract: The present invention relates to relates to a method of producing an improved asphalt. This method includes providing an asphalt binder and providing a compound of formula (I): as described herein. The asphalt binder is mixed with the compound of formula (I) under conditions effective to produce an improved asphalt. Also disclosed are an asphalt product and a method of making asphalt material.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 25, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Ronald Christopher Williams, Joseph H. Podolsky, Nacu Hernandez, Eric W. Cochran, Austin Hohmann, Mohamed Elkashef
  • Patent number: 10564122
    Abstract: An electrophoresis chip-based setup for detection of different ions in buffer solution. The device is able to differentiate ions in, e.g., real soil or other solutions, and to detect concentration of a specific ion in the solution. Fabrication of the electrophoresis chip can use a soft lithography based molding process. The chip can be made out of PDMS on a glass substrate where on-chip valves were used to control timing of injecting sample and buffer solutions. Detection electrodes are used to detect the presence of ions over a period of several minutes. A controllable high voltage power supply system and related signal acquisition, processing and detection setup can be implemented with the sensor in a system. A microfluidic system for automated collection of soil sample through a porous ceramic and using vacuum suction can be used.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: February 18, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Zhen Xu, Liang Dong, Ratnesh Kumar
  • Patent number: 10550210
    Abstract: The present invention is directed to polyisocyanates and polyurethanes derived therefrom. In various embodiments, the present invention provides polyisocyanates, methods of making the polyisocyanates from fused bicyclic alcohols, polyurethanes, and methods of making the polyurethanes from the polyisocyanates.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: February 4, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Jason Shih-Hao Chen, Michael Richard Kessler, Michael Dennis Zenner
  • Patent number: 10532964
    Abstract: Herein disclosed is an economical standalone system that replaces conventional monomer purification methods needed to perform chemical reactions that require reactants with a high degree of purity. Chemical reactions, such as anionic polymerization, can produce highly monodisperse homopolymers and block copolymers, however to do so they require very high purity reactants along with a moisture and oxygen free atmosphere. The system and method uses traditional column purification methods, but incorporates them into an economical, standalone, compact, and hazard free system. This method is different in view of safety, cost of cleaning procedure, time commitment, space availability, design and operational ease; helping researchers save time by cutting down the operating commitment by 90% and most importantly making it safer.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 14, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Sri Harsha Kalluru, Nacu Hernandez, Eric W. Cochran
  • Patent number: 10526694
    Abstract: A method of preparing an ultra-flat metal surface involves providing a layer of a crystalline metallic material on an ultra-flat substrate surface that is relatively harder than the metallic material layer and then impinging the metallic material layer with incoming metal atoms that are deposited as an additive crystalline layer thereon, wherein at least a lattice constant of the additive crystalline layer is different enough from a lattice constant of the crystalline metallic material layer resulting in a reduction of roughness of the surface of the metallic material layer adjacent to the substrate surface. The metallic material layer having an ultra-flat surface then is separated by template stripping or other technique from the substrate surface for further use of the ultra-flat surface.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: January 7, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Martin Thuo, Jiahao Chen, Ian D. Tevis
  • Patent number: 10525472
    Abstract: Apparatus, methods, and systems for automated liquid droplet manipulation include an open droplet supporting surface. An actuator can translate the surface in space with at least one degree freedom of movement to influence movement of one or more droplets on the surface. In one embodiment, the surface is patterned with areas that attract the droplets and interstitial areas that repel the droplets to enhance transport of droplets. For example, for water-based droplets the attracting areas can be hydrophilic and the repelling hydrophobic. In one embodiment, the repelling areas are superhydrophobic. Electromechanical movement of the surface avoids expensive and complex microfluidic fabrication and components, and avoids electrowetting requirements.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: January 7, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Santosh Pandey, Riley Brien, Taejoon Kong, Zach Njus, Jared Anderson
  • Patent number: 10501448
    Abstract: Various embodiments disclosed relate to aziridinated triglycerides and polymers formed therefrom. In various embodiments, the present invention provides an aziridinated triglyceride having the structure described herein. In various embodiments, the present invention provides a method of making the aziridinated triglyceride, a method of crosslinking the aziridinated triglyceride to form a polymer, the polymer formed from the aziridinated triglyceride, a triglyceride with at least one pendent unsaturated group that can be used to form the aziridinated triglyceride, and a method of making the triglyceride having at least one pendent unsaturated group.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 10, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Ruqi Chen, Jason Shih-Hao Chen, Chaoqun Zhang, Michael Richard Kessler
  • Publication number: 20190365887
    Abstract: Immunogenic compositions and methods of using them include a biodegradable or bioerodible polyanhydride nanoparticle comprising 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers, an immunogenic protein of an Influenza Virus and an adjuvant entrapped within an interior of the nanoparticle, and an excipient. The immunogenic composition may be administered to a subject to confer both local and systemic immunity to the Influenza Virus.
    Type: Application
    Filed: March 29, 2019
    Publication date: December 5, 2019
    Applicants: Iowa State University Research Foundation, Inc., University of Iowa Research Foundation
    Inventors: Balaji NARASIMHAN, Kathleen A. Ross, Kevin L. Legge, Thomas J. Waldschmidt
  • Patent number: 10493153
    Abstract: The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: December 3, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Arthur Henry Winter
  • Patent number: 10477775
    Abstract: A crop sensing system for a baler includes a compression system for forming a bale and a feed system for picking up crop from a surface and conveying the crop to the compression system. The crop sensing system includes a sensor arrangement having at least one sensor being coupled to at least one of the compression system or the feed system, wherein the at least one sensor generates a signal corresponding to a crop load on the at least one of the compression system or the feed system. The crop sensing system includes a control unit configured to receive the signal from the sensor arrangement and calculate crop mass data based on at least the signal.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: November 19, 2019
    Assignees: DEERE & COMPANY, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Eric R. Lang, Jeffrey Askey
  • Patent number: 10470379
    Abstract: Systems, methods, and apparatus for large scale, high throughput phenotyping of items including plants to derive environment/genetics correlations based on controlled variation of environment. Spatial and temporal resolution is improved by an integrated system that can use space efficiently yet concurrently process a large number of replicates but in varying environments. This is accomplished by using an array of miniature greenhouses, each in communication with one or more generators or regulators of an environmental factor that can be independently supplied and controlled to each miniature greenhouse. The controller also controls acquisition of data from each greenhouse as well as processing of that data into phenomic/genomic correlations.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: November 12, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Liang Dong, Huawei Jiang, Maneesha Aluru
  • Patent number: 10463656
    Abstract: Methods for preventing feedlot bovine respiratory diseases employing an anti-inflammatory drug rupatadine are disclosed. Compositions are further disclosed. Beneficially, the methods and compositions provide safe and cost-effective management of a costly disease.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: November 5, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Steven Alan Carlson, Timothy L. Day
  • Patent number: 10457892
    Abstract: This invention relates to a wax composition comprising one or more fatty acid diester compounds having the formula of R1 and R2 are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; and n1 is an integer from 2 to 10. This invention also relates to a wax composition comprising: a) one or more fatty acid monoester or diester compounds having the formula of: and b) one or more hydroxylated fatty acid diester compounds having the formula of In these formulae, R is H or COR1?; R1? and R2? are each independently a substituted or unsubstituted C4 to C50 alkyl or aryl; n2 is an integer from 2 to 24; m is an integer from 2 to 12; and .(OH)m represents 2 to 12 hydroxyl groups substituting for 2 to 12 hydrogen atoms in the alkyl groups R1? and/or R2?. Uses of the compositions are also disclosed.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Tong Wang, Tao Fei
  • Patent number: 10457904
    Abstract: A system, method, and apparatus for the fermentation of a beverage by use of continuous flow is provided. The fermented beverage can be any of a wine, beer, mead, ale, soda, cider, or other. The invention provides for small-scale fermentation that can be done in a much shorter time than previous batch fermentations. The small-scale and shortened time allows for variables to be introduced and tested to produce new varieties, flavors, qualities, and other combinations that are inputs of the fermented beverage.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Daniel Attinger, Liang Dong, Yuncong Chen
  • Patent number: 10457882
    Abstract: The present invention is directed to a method of producing a solid fuel which includes providing a bio-oil and thermally curing the bio-oil to form a carbonaceous solid. The present invention is also directed to a method of producing a solid fuel which includes providing a bio-oil; subjecting the bio-oil to an extraction procedure with an aqueous liquid to produce a concentrated pyrolytic sugar-containing extract and a water insoluble raffinate comprising a lignin-derived phenolic oil; and thermally curing the phenolic oil to form a carbonaceous solid.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: October 29, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Robert C. Brown, Marjorie Rover, Andrew J. Friend, Ryan G. Smith
  • Patent number: 10442118
    Abstract: To better control part quality of 3D printed parts, the temperature of an extruder filament using a secondary heat source is provided. A heat source, such as an infrared heat source, can be used to heat the filament of a 3D printer to the optimum temperature that will enhance welding of the filament to a substrate that it is being printed on or to. Such an optimum temperature can be based upon, in part, the temperature of the substrate. A controller or other intelligent control can be used to receive temperature readings of the substrate and/or filament and then can adjust the temperature of the heating source to optimize the temperature of the filament to better combine the filament to the substrate.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: October 15, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: David Grewell
  • Patent number: 10446852
    Abstract: The present invention relates to a fuel-cell system. This system includes an anode electrode; a cathode electrode; a separator positioned between the anode electrode and the cathode electrode, wherein the separator is not an ion exchange membrane; an anode catalyst; and a cathode catalyst, wherein the cathode catalyst is a non-precious metal catalyst or metal-free catalyst. The present invention also relates to a method of generating energy from crude fuel. This method involves providing a fuel-cell system and contacting the fuel-cell system with a crude fuel under conditions effective to generate energy from the crude fuel.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 15, 2019
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Wenzhen Li, Neeva Benipal, Ji Qi, Yang Qiu