Patents Assigned to IRM LLC, a Delaware Limited Liability Company
  • Publication number: 20040101915
    Abstract: This invention provides methods of identifying compounds that selectively target cancer cells that have defects in specific oncogenic pathways.
    Type: Application
    Filed: June 18, 2003
    Publication date: May 27, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Quinn L. Deveraux, Klaus W. Wagner, Garrett M. Hampton
  • Publication number: 20040006176
    Abstract: The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
    Type: Application
    Filed: November 27, 2002
    Publication date: January 8, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Robert Epple, William Greenberg, Romas Kudirka
  • Publication number: 20030225205
    Abstract: The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
    Type: Application
    Filed: May 8, 2003
    Publication date: December 4, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Robert Epple, William Greenberg, Romas Kudirka
  • Publication number: 20030191312
    Abstract: General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, boronic acids and phenols via palladium catalyzed cross-coupling reactions.
    Type: Application
    Filed: October 12, 2002
    Publication date: October 9, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Sheng Ding, Qiang Ding, Nathanael S. Gray
  • Publication number: 20030186324
    Abstract: This invention provides G protein-coupled receptors that are expressed in mammalian sensory neurons of dorsal root ganglia. Both nucleic acids that encode the receptors, and the receptor polypeptides are provided.
    Type: Application
    Filed: September 6, 2002
    Publication date: October 2, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Jiayu Liao, Nathanael S. Gray, Jeremy C. Caldwell, Peter G. Schultz
  • Publication number: 20030171583
    Abstract: The invention provides general methods for preparing 2,9-, 2,6,9-, O6-aryl- and O6-alkyl-substituted purines in a combinatorial and traceless fashion. The methods involve, in some embodiments, Mitsunobu alkylation of 2-fluoro-6-phenylsulfenylpurine at N9 with alcohols in solution, followed by C2-capture of the purine core with a resin-bound amine and subsequent oxidation and displacement of the C6 sulfonyl group with amines and anilines.
    Type: Application
    Filed: October 12, 2002
    Publication date: September 11, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Sheng Ding, Qiang Ding, Nathanael S. Gray, Peter G. Schultz
  • Publication number: 20030138793
    Abstract: This invention provides methods, kits, and algorithms for obtaining molecular signatures of cells based on their gene expression profiles. Devices for carrying out molecular signature analysis of unknown samples are also provided.
    Type: Application
    Filed: June 10, 2002
    Publication date: July 24, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Andrew I. Su, Garret M. Hampton
  • Publication number: 20020090320
    Abstract: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.
    Type: Application
    Filed: October 15, 2001
    Publication date: July 11, 2002
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Kristina Marie Burow, Jeremy S. Caldwell, Robert Charles Downs, Scott Allan Lesley, James Kevin Mainquist, Andrew J. Meyer, Daniel G. Sipes, Mark Richard Weselak