Patents Assigned to ITI Scotland Limited
  • Patent number: 10370901
    Abstract: Provided is an apparatus for use in directional drilling, which apparatus comprises: (a) a drill bit; (b) at least one steering actuator capable of exerting a longitudinal force on the drill bit, so as to change the direction of drilling; and/or (c) at least one drill bit steering insert, capable of extending and retracting so as to change the cutting characteristics of the drill bit and thereby change the direction of drilling. Further provided is a method of directional drilling, employing the apparatus of the invention.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: August 6, 2019
    Assignee: ITI Scotland Limited
    Inventor: Marian Wiercigroch
  • Patent number: 10125547
    Abstract: Provided is an apparatus for use in resonance enhanced drilling, which apparatus comprises a drilling module comprising a drill-bit, wherein the apparatus further comprises: a sensor for measuring one or more parameters relating to the interaction of the drill-bit and the material being drilled; and a sensor for measuring one or more motions of the drill-bit.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: November 13, 2018
    Assignee: ITI Scotland Limited
    Inventor: Marian Wiercigroch
  • Patent number: 10067143
    Abstract: The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cull, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: September 4, 2018
    Assignee: ITI Scotland Limited
    Inventor: Jonathan Peter Clark
  • Patent number: 10024865
    Abstract: The present invention related to a method of assaying ubiquitination in a sample by combining ubiquitin and two or more of E1, E2, E3 and a substrate protein in a sample under conditions suitable for ubiquitination to take place, exposing the sample with a labelled binding partner which is specific for the ubiquitin and measuring the amount of labelled ubiquitin bound to any one of the components in the sample, wherein one or more of the components in the sample comprises an immobilization tag which facilitates its immobilization onto a solid surface.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 17, 2018
    Assignee: ITI Scotland Limited
    Inventor: Jonathan Peter Clark
  • Patent number: 9777305
    Abstract: Provided herein are methods for the assembly of a polynucleic acid sequence that is at least partially carried out on a microfluidic device; methods for the preparation of a library of polynucleic acid sequences; microfluidic devices; methods for designing nucleic acid sequences; methods for planning the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences; systems comprising components for carrying out these methods; computer programs which, when run on a computer, implements these methods; and computer readable medium or carrier signals encoding such a computer program.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: October 3, 2017
    Assignee: Iti Scotland Limited
    Inventors: Austin Che, Tom Knight, Barry Canton, Jason Kelly, Reshma Shetty, Maiwenn Kersaudy Kerhoas, Farid Amalou, Will Shu
  • Patent number: 9777337
    Abstract: Provided is a method for detecting analyte in a sample, which method comprises: (a) contacting the sample with a peptide nucleic acid (PNA) probe; (b) performing an electrochemical impedance spectrometry (EIS) measurement on the sample; (c) determining the presence, absence, quantity and/or identity of the analyte from the EIS measurement; wherein the analyte comprises nucleic acid; and wherein the quantity of analyte in the sample when the sample is taken is substantially the same as the quantity of analyte in the sample when the sample is subjected to the EIS measurement.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: October 3, 2017
    Assignee: ITI Scotland Limited
    Inventors: Holger Schulze, Damion Corrigan, Till Bachmann
  • Patent number: 9725965
    Abstract: An apparatus for use in resonance enhanced rotary drilling. The apparatus comprising one or both of: (a) a vibration isolation unit; and (b) a vibration transmission unit. The vibration isolation unit and/or the vibration transmission unit typically comprising a spring system comprising two or more frusto-conical springs arranged in series.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: August 8, 2017
    Assignee: ITI SCOTLAND LIMITED
    Inventor: Marian Wiercigroch
  • Patent number: 9689513
    Abstract: The present invention provides a tubular article (10), such as may be used as an oil and gas pipeline, having a longitudinal axis X comprising inner and outer separate strips (12, 14) of spirally wound overlapping material each having a longitudinal axis L and first and second edges (16, 18, 16?, 18?), in which each strip (12, 14) comprises two or more longitudinally extending ridges (20, 22, 20?, 22?), each of which extends along said longitudinally extending axis L in parallel to each other and in which said ridges (20, 22, 20?, 22?) each comprise asymmetric ridges having a leading edge (24, 24?) forming a contact portion (28, 28?) and wherein said leading edges (24, 24?) are each in contact with each other and further comprising a non-contact trailing edge portion (26, 26?) which are spaced from each other by an amount G.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: June 27, 2017
    Assignee: ITI SCOTLAND LIMITED
    Inventor: Andrew Stevenson
  • Patent number: 9587443
    Abstract: Provided is apparatus for use in resonance enhanced rotary drilling, which apparatus comprises: (i) an upper load-cell for measuring static and dynamic axial loading; (ii) a vibration isolation unit; (iii) optionally an oscillator back mass; (iv) an oscillator for applying axial oscillatory loading to the rotary drill-bit; (v) a vibration transmission unit; (vi) a lower load-cell for measuring static and dynamic axial loading; (vii) a drill-bit connector; and (viii) a drill-bit, wherein the upper load-cell is positioned above the vibration isolation unit and the lower load-cell is positioned between the vibration transmission unit and the drill-bit, and wherein the upper and lower load-cells are connected to a controller in order to provide down-hole closed loop real time control of the oscillator.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: March 7, 2017
    Assignee: ITI SCOTLAND LIMITED
    Inventor: Marian Wiercigroch
  • Publication number: 20160251901
    Abstract: Provided is an apparatus for use in resonance enhanced drilling, which apparatus comprises a drilling module comprising a drill-bit, wherein the apparatus further comprises: a sensor for measuring one or more parameters relating to the interaction of the drill-bit and the material being drilled; and a sensor for measuring one or more motions of the drill-bit.
    Type: Application
    Filed: October 9, 2014
    Publication date: September 1, 2016
    Applicant: ITI Scotland Limited
    Inventor: Marian Wiercigroch
  • Patent number: 9366622
    Abstract: An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: June 14, 2016
    Assignee: ITI SCOTLAND LIMITED
    Inventor: Damien Weidmann
  • Patent number: 9217822
    Abstract: This invention relates to structures for mounting LEDs, the structures being suitable for use in the manufacture of light guide devices. This invention also relates to light guide devices comprising the structures and methods of manufacture of the aforementioned. The light guide devices are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: December 22, 2015
    Assignee: ITI SCOTLAND LIMITED
    Inventors: Neil Griffin, Neil Pollock
  • Patent number: 9164223
    Abstract: This invention relates to light guide devices and methods of manufacture. The light guide device is suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: October 20, 2015
    Assignee: ITI SCOTLAND LIMITED
    Inventor: James Gourlay
  • Patent number: 9068400
    Abstract: A method for controlling a resonance enhanced rotary drill comprising a rotary drill bit and an oscillator for applying axial oscillatory loading to the rotary drill bit, the method comprising: controlling frequency (f) of the oscillator in the resonance enhanced rotary drill whereby the frequency (f) is maintained in the range (D2 Us/(8000 ?Am))1/2?f?Sf(D2 Us/(8000 ?Am))1/2 where D is diameter of the rotary drill bit, Us is compressive strength of material being drilled, A is amplitude of vibration, m is vibrating mass, and Sf is a scaling factor greater than 1; and controlling dynamic force (Fd) of the oscillator in the resonance enhanced rotary drill whereby the dynamic force (Fd) is maintained in the range [(?/4)D2effUs]?Fd?SFd[(?/4)D2effUs] where Deff is an effective diameter of the rotary drill bit, Us is a compressive strength of material being drilled, and SFd is a scaling factor greater than 1, wherein the frequency (f) and the dynamic force (Fd) of the oscillator are controlled by monitori
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: June 30, 2015
    Assignee: ITI Scotland Limited
    Inventor: Marian Wiercigroch
  • Patent number: 9022332
    Abstract: Clamp for clamping an article including a plurality of pads (10) which may be arranged in a circle around a support frame (90) and pivotally connected thereto by pivot arms (26) pivotable about an axis parallel to the axis of an article (92) to which the pads (10) are to be clamped. The pads (10) are supported on the arms (26) by ball-joints or universal joints (48) such as to ensure any off-center load L is passed through said pads (10) as a vertical load having no radial component.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: May 5, 2015
    Assignee: ITI Scotland Limited
    Inventor: Kevan Frederick Stokes
  • Patent number: 8999679
    Abstract: The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13 at the 3?-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23? at the 3?-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25? at the 5?-end of the nucleic acid sequence, wherein the 5?-end linker sequence L25? of nucleic acid sequence N2 is complementary to the 3?-end linker sequence L13? of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 7, 2015
    Assignee: Iti Scotland Limited
    Inventors: Austin Che, Tom Knight, Barry Canton, Jason Kelly, Reshma Shetty
  • Patent number: 8955362
    Abstract: An apparatus (50) for and method of manufacturing helically wound tubular structures (116) includes a rotating faceplate (74) upon which are mounted a plurality of diameter defining rollers (78) which, in operation, cause a strip material (80) to be plastically deformed into a helical winding which may be lain down in abutting or self-overlapping relationship to form said tubular structure (116).
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: February 17, 2015
    Assignee: ITI Scotland Limited
    Inventor: John Peter Booth
  • Publication number: 20150014543
    Abstract: An active heterodyne detection system comprises a continuously tuneable laser source (1) emitting infra-red radiation, means (8) to split the infra-red radiation into a first part and a second part, means (4) to provide a frequency shift between the first part and the second part, means (8, 9) to direct the first part of the infra-red radiation to a target (2), means (4) to provide the second part of the infra-red radiation as a local oscillator, means (8, 9) to collect a scattered component of the first part of the infra-red light from the target (2), and means (5) to mix the scattered component and the local oscillator and route them to a detector (3) for heterodyne detection over a continuous spectral range. A method of active heterodyne detection over a continuous spectral range is also disclosed.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 15, 2015
    Applicant: ITI SCOTLAND LIMITED
    Inventor: Damien Weidmann
  • Patent number: 8809619
    Abstract: The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and chemicals for therapeutic use or for other purposes is extremely complex. Of particular importance is the understanding of how these chemical agents are handled in the body, whether they have appropriate pharmacokinetics and whether, as a consequence of metabolism, any safety issues arise. Many of the proteins that are involved in the metabolism, disposition and elimination of drugs are members of multigene families that exhibit very marked species differences in gene number, function and regulation. For these reasons, experiments carried out in laboratory animals to establish routes of metabolism or toxicity can be severely compromised and, as a consequence, do not faithfully represent the human situation.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: August 19, 2014
    Assignee: ITI Scotland Limited
    Inventors: Nico Scheer, Charles Roland Wolf
  • Patent number: 8778157
    Abstract: Provided is a method for processing a sample, which method comprises: a) contacting a binding phase, which binding phase is capable of binding an analyte, with the sample in the presence of a medium; b) applying across the medium a first alternating field composed of a plurality of pulses and having a first frequency, a first pulse duration and a first pulse rise time; c) optionally applying across the medium a second alternating field; and d) thereby influencing the sample and/or the binding phase in the medium.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: July 15, 2014
    Assignee: ITI Scotland Limited
    Inventors: Holger Schulze, Till Bachmann, Andrew Mount