Abstract: Provided is a method for detecting an analyte, which method comprises: a) applying an alternating voltage to the analyte, wherein the alternating voltage comprises a plurality of superimposed frequencies sufficient to distinguish the presence of the analyte by electrochemical impedance spectrometry (EIS); and b) determining the identity and/or quantity of the analyte from EIS data.

Abstract: Provided is a microfluidic or nanofluidic apparatus which comprises: (a) a reservoir for one or more fluids; (b) a mixing device configured to mix the one or more fluids within the reservoir; and (c) a microfluidic or nanofluidic device in fluid connection with the reservoir; wherein the reservoir is suitable for containing a total volume of fluid of from 100 microliters to 100 milliliters. Also provided is a method of manufacturing the apparatus and the use of the apparatus to detect an analyte in a fluid.

Abstract: A battery management system includes a neural network, for estimating an amount of charge stored in a battery following a recharging operation. Then, an amount of charge drawn during a discharging operation is subtracted from this estimated amount of charge to derive an estimate for the state of charge of the battery at a present time. A parameter representing the state of health of the battery may be provided as an input to the neural network, and the parameter representing the state of health of the battery may be generated by a second neural network.

Abstract: Provided is a microfluidic mixing system comprising a loop system for transferring one or more fluids, wherein the loop system comprises a plurality of sub loops, each sub loop formed from one or more common channels shared with at least one other sub loop and completed by an outer channel portion that is not shared by any other sub loop, and wherein the outer channel portion of each sub loop comprises one or more valves such that the sub loop is capable of isolation from all other sub loops and each common channel comprises one or more valves such that the common channel is capable of isolation from the remainder of the loop system, and wherein one or more sub loops in the system comprise valves that are configured to enable peristaltic mixing.

Abstract: A method for controlling a resonance enhanced rotary drill comprising a rotary drill bit and an oscillator for applying axial oscillatory loading to the rotary drill bit, the method comprising: controlling frequency (f) of the oscillator in the resonance enhanced rotary drill whereby the frequency (f) is maintained in the range (D2 Us/(8000 ?Am))1/2?f?Sf(D2 Us/(8000 ?Am))1/2 where D is diameter of the rotary drill bit, Us is compressive strength of material being drilled, A is amplitude of vibration, m is vibrating mass, and Sf is a scaling factor greater than 1; and controlling dynamic force (Fd) of the oscillator in the resonance enhanced rotary drill whereby the dynamic force (Fd) is maintained in the range [(?/4)D2effUs]?Fd?SFd[(?/4)D2effUs] where Deff is an effective diameter of the rotary drill bit, Us is a compressive strength of material being drilled, and SFd is a scaling factor greater than 1, wherein the frequency (f) and the dynamic force (Fd) of the oscillator are controll

Abstract: This invention relates to film layer which is suitable for use in a light guide plate and methods of forming said film layer and light guide plate. The invention also relates to the light guide plate and light guide devices made therefrom. The film and light guide plate are suitable for use in a range of applications, particularly in connection with the backlighting of displays, for example, liquid crystal displays.

Abstract: The present invention provides a loading element for reversibly coupling a microfluidic or nanofluidic cartridge to a processing apparatus wherein the loading element comprises: (a) a first connector part comprising a first set of air inlet ports and a first set of air outlet ports; (b) a second connector part comprising a second set of air inlet ports and a second set of air outlet ports; and (c) a guide part configured to guide the cartridge into reversible coupling with the loading element.

Abstract: Provided is a processing apparatus for enabling a plurality of processes to be conducted on a sample within a microfluidic or nanofluidic cartridge, the apparatus comprising: a) a plurality of processing modules for facilitating the processes conducted on the sample within the cartridge; b) a coupling means for reversibly coupling the cartridge to the apparatus; c) a transport means capable of bringing the cartridge coupled to the coupling means into communication with each of the processing modules; wherein the plurality of processing modules includes a component isolation module capable of facilitating a separation process within the cartridge, a manipulator module capable of facilitating the movement of fluids within the cartridge; and an optical module capable of interacting optically with the cartridge.

Abstract: There is disclosed a clamp, a self-advancing climbing device including two such clamps, and a method of coupling such a clamp to a tubular. In one embodiment of the invention, there is disclosed a clamp (1) for a tubular, in particular a thin-walled tubular such as the tower (3) of a wind-turbine. The clamp (1) comprises at least one clamp member in the form of a friction pad (9) adapted to grip the tower (3), and at least one flexible elongate energising element in the form of a tendon (16) adapted to exert a force on the friction pad (9) to urge the pad (9) to grip the tower (3), whereby the pad (9) and the tendon (16) are adapted to exert a substantially uniform radial clamp load on the tower (3).

Abstract: system and method for automatically identifying a source of a run-time error in a computer system comprises a static analysis system (SAS), an instrumentation system (IS) and a post-execution analysis system (PEAS). The is arranged to generate static analysis data on computer program code (CPC) for the computer system, including information on possible behaviors of the CPC when executed. The IS is arranged to instrument the CPC by inserting marker triggers into the CPC that, generate a marker associated with each of a number of predetermined points in the CPC that would be reached during execution of the CPC. Each marker is, uniquely identifiable. The predetermined points are determined in dependence on the static analysis data. The PEASpost execution analysis system is arranged to processes data on a run-time error produced by execution of the instrumented CPC, wherein the generated markers and the static analysis data to identify the source of the run-time error.

Abstract: A wave and wind power generation system including a platform and one or more oscillating water columns (OWC's). Included is an airflow control mechanism, a controller and a motion sensor for detecting motion of the platform. Additionally, the controller controls the airflow control mechanism so as to at least partially arrest undesirable motion of the platform.

Abstract: A system for teaching a learning objective is provided. The system includes a software application comprising an application logic component and that provides a user view and a facilitator view. An intervention control is arranged to interface directly with the application logic component. A method is also disclosed for teaching a learning objective and includes the steps of executing a software application that includes an application logic component and that provides a user view and a facilitator view; and using an intervention control to interface directly with the application logic component. The system and method may be implemented as part of programmed instructions in a computer system and/or a computer readable medium.

Abstract: A computer system is described in which the execution environment of the system is distributed between a server execution environment and a client execution environment of a client apparatus. Client components executed within the client execution environment are selected to be a primary client component in dependence on a property of an instance of program execution in the client execution environment.

Abstract: A winding apparatus for and method of manufacturing structures (116) includes a rotating faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure and a plurality of inner supports in the form of rollers (110) mounted for rotation about an axis and with said faceplate and a plurality of outer driven rollers (92) provided on an outer faceplate (118). The inner rollers (110) are mounted for radial movement relative to the inner faceplate (74). In operation, the inner rollers (110) act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer rollers (92) act to support an outer portion S2 of said strip.

Abstract: A winding apparatus for and method of manufacturing helically wound structures (116) includes: a rotating faceplate (74) upon which are mounted a forming station for forming a supply of strip material before it is wound into a desired structure; a plurality of inner supports in the form of rollers (110) mounted for radial displacement and rotation about an axis; an outer faceplate (118) having a plurality of outer support rollers (92) mounted for radial displacement and rotation about an axis. In operation, the inner rollers act to support an inner portion S1 of strip material wound thereon whilst allowing it to be supplied from an inner diameter thereof to said forming station and the outer rollers (92) act to support an outer portion S2 of said strip. The inner rollers (110) are moved radially to maintain support of said strip material as it is consumed.

Abstract: The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13 at the 3?-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23? at the 3?-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25? at the 5?-end of the nucleic acid sequence, wherein the 5?-end linker sequence L25? of nucleic acid sequence N2 is complementary to the 3?-end linker sequence L13? of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an

Abstract: Disclosed is a computer-implemented method of presenting data which has been automatically extracted from a digital representation of a document to a curator for review, the extracted data comprising annotation entity data concerning one or more instances of entities which have been identified in the digital representation of a document, the annotation entity data comprising data specifying the location of the identified instances of entities within the digital representation of a document, the method comprising the steps of (i) displaying in a first region of a display screen a user selectable portion of the digital representation of a document with said instances of entities which are specified by the annotation entity data as being located within the displayed portion of the digital representation of a document highlighted at the location specified by the annotation entity data; (ii) displaying in a second region of the display screen a list of a plurality of instances of entities which have been identifie

Abstract: A method of assigning an identifier to a mention of an entity in a document carried out by computing apparatus including a display and one or more user operable input devices. A plurality of candidate identifiers are received from a term identification module in respect of a mention of an entity in a document, each candidate identifier being a reference to an entity in connection with which entity property data is stored in one or more entity databases. A list is displayed in a first region of the display, the list having a plurality of user-selectable entries, each entry in the list concerning the entity referred to by one of the said plurality of candidate identifiers, each entry comprising properties of the respective entity. At least one of the said properties is retrieved from the said one or more entity databases.

Abstract: A microfluidic system comprising a 1st reaction zone, a 2nd reaction zone, a reagent delivery channel configured to deliver one or more reagents to the 1st reaction zone, a waste channel to remove waste from the 2nd reaction zone, a 1st sample delivery channel configured to deliver a sample to the 1st reaction zone and a 2nd sample delivery channel configured to deliver a sample to the 2nd reaction zone; wherein the microfluidic system comprises a means for retaining one or more reagents in each reaction zone; and wherein the 1st reaction zone and 2nd reaction zone are connected in series by a reaction zone channel.

Abstract: An apparatus (50) for and method of manufacturing structures (116) includes coaxial rotating faceplates (74, 89, 97), capable of rotation at different angular speeds. A plurality of forming rollers (76) and diameter defining rollers (78) are mounted on the inner faceplate (74, 89), which, in operation, cause a strip material (80) to be plastically deformed into a helical winding which may be lain down in abutting or self-overlapping relationship to form said tubular structure (116). A plurality of support rollers are mounted in a circle on the inner faceplate (74, 89) at a distance from the axis exceeding that of the outermost forming roller and serve to support the stock of strip material.