Patents Assigned to Janssen Pharmaceuticals, Inc.
  • COMBINATION THERAPY FOR TREATING HEPATITIS B VIRUS INFECTION
    Publication number: 20200332297
    Abstract: Described are RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B Virus (HBV) used in combination with a capsid assembly modulator (CAM) and methods of administering same. The HBV RNAi agents and CAMs are administered in ratios to effectively inhibit HBV gene expression and to treat diseases and conditions associated with HBV infection.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 22, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: Michael BIERMER, Ronald KALMEIJER, Oliver LENZ, Maria Gloria BEUMONT-MAUVIEL, Jan SNOEYS, Kenneth Alan SIMMEN
  • COMBINATION THERAPY FOR TREATING HEPATITIS B VIRUS INFECTION
    Publication number: 20200330499
    Abstract: Described are RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B Virus (HBV) used in combination with a capsid assembly modulator (CAM) and methods of administering same. The HBV RNAi agents and CAMs are administered in ratios to effectively inhibit HBV gene expression and to treat diseases and conditions associated with HBV infection.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 22, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: Michael BIERMER, Ronald KALMEIJER, Oliver LENZ, Maria Gloria BEUMONT-MAUVIEL, Jan SNOEYS, Kenneth Alan SIMMEN
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10786484
    Abstract: The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: September 29, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200299235
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 24, 2020
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Jean-François Bonfanti, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10765662
    Abstract: The present invention concerns mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: September 8, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200270209
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 13, 2020
    Publication date: August 27, 2020
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Dorothée Alice Marie-Eve BARDIOT, Arnaud Didier M MARCHAND
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200255376
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 18, 2018
    Publication date: August 13, 2020
    Applicants: JANSSEN PHARMACEUTICALS, INC., KATHOLIKE UNIVERSITEIT LEUVEN
    Inventors: Jean-François Bonfanti, Bart Rudolf Romania Kesteleyn, Dorothée Alice Marie-Eve Badiot, Amaud Didier M Marchand, Erwin Coesemans, Jérôme Michel Caude Fortin, Guillaume Jean Maurice Mercey, Pierre Jean-Marie Bemard Rabisson
  • Substituted indole compound derivatives as dengue viral replication inhibitors
    Patent number: 10730884
    Abstract: The present invention concerns substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 4, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Cosemans
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10696632
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 30, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Accessory for an Injection Device including a Grip for a Needle Cap
    Publication number: 20200197623
    Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip, the cap remover having an expanded configuration in which the needle cap can pass between the grip, and a constricted configuration in which the grip holds the needle cap to at least partially remove the needle cap from the injection device.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 25, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: James D. McLusky, Nick Foley, Gavin F. McDougall, Roy A. Crerar, James N. Mower
  • Accessory Including a Slot for a Flange of an Injection Device
    Publication number: 20200197624
    Abstract: An accessory for an injection device having a safety shield and at least one flange adapted to allow a user to grip the injection device and a syringe sheath moveable relative to the at least one flange from a pre-injection position to a locked-out position. The accessory comprises a body portion comprising a recess adapted to receive the safety shield of the injection device and a slot adapted to receive the at least one flange of the injection device.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 25, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: James D. McLusky, Nick Foley, Gavin F. McDougall, Roy A. Crerar, James N. Mower
  • Accessory for an Injection Device including a Pivotable Cover
    Publication number: 20200197622
    Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip adapted to hold the needle cap. The cap remover is moveable with respect to the body portion.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 25, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: James D. McLusky, Nick Foley, Gavin F. McDougall, Roy A. Crerar, Jame N. Mower
  • Accessory for an Injection Device Including an Exposed Cap Remover
    Publication number: 20200197625
    Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position and a closed position. The accessory further comprises a cap remover comprising a grip adapted to hold the needle cap. The body portion comprises a track within which the cap remover is arranged to move axially with respect to the body portion. The track is adapted such that when the injection device is located in the body portion the cap remover is held against the track by the injection device.
    Type: Application
    Filed: December 17, 2019
    Publication date: June 25, 2020
    Applicant: Janssen Pharmaceuticals, Inc.
    Inventors: James D. McLusky, Nick Foley, Gavin F. McDougall, Roy A. Crerar, James N. Mower
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 10689340
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: June 23, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Jean-François Bonfanti, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200181083
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 11, 2020
    Applicants: JANSSEN PHARMACEUTICALS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Jean-Francois Bonfanti, Bart Rudolf Romanis Kesteieyn, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Coesemans, Benoit Christian Albert Ghi De Boeck, Pierre Jean-Marie Bernard Raboisson
  • Substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10646469
    Abstract: The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 12, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Injection device
    Patent number: D888942
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: June 30, 2020
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Michael Cannamela, Rochelle Kleinberg, Peter Krulevitch
  • Grip accessory for a manual injection device
    Patent number: D902391
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: November 17, 2020
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Ian Scrimgeour, James McLusky, Nick Foley, Peter Krulevitch, Jimmy Mower, Michael Cannamela, Kui Liu
  • Grip accessory for a manual injection device
    Patent number: D902392
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: November 17, 2020
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Ian Scrimgeour, James McLusky, Nick Foley, Peter Krulevitch, Jimmy Mower, Michael Cannamela, Kui Liu
  • Injection device
    Patent number: D902393
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: November 17, 2020
    Assignee: Janssen Pharmaceuticals, Inc.
    Inventors: Michael Cannamela, Rochelle Kleinberg, Peter Krulevitch