Patents Assigned to Japan Foundation for Artificial Organs
  • Patent number: 4350156
    Abstract: An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous.
    Type: Grant
    Filed: May 29, 1980
    Date of Patent: September 21, 1982
    Assignee: Japan Foundation for Artificial Organs
    Inventors: Paul S. Malchesky, Yukihiko Nose
  • Patent number: 4311587
    Abstract: A filter connection for peritoneal dialysis is presented including, in a flow line from a source of fresh dialysate solution carried on the patient's body, and under pressure, through a bacteria filter of sub-micron porosity for removing microorganisms generally greater than about 0.2 microns (nominal size) together with tubular connections leading from the filter toward a catheter inserted in the patient's peritoneum including in order from the filter, a first check valve permitting flow only away from the filter, then an outflow port with check valve permitting used dialysis flow only away from the patient, and finally the connection to the catheter tube.
    Type: Grant
    Filed: December 10, 1979
    Date of Patent: January 19, 1982
    Assignee: Japan Foundation for Artificial Organs
    Inventors: Yukihiko Nose, Paul S. Malchesky
  • Patent number: 4128479
    Abstract: A unit is presented for the transfer of a gaseous component in one stream to or from a liquid component in another stream, in which a membrane assembly is wound spirally around a central rigid cylindrical core. The membrane assembly comprises a continuous length of flattened tubular membrane with a gas net passing through the intermediate portion of the membrane from end to end thereof and substantially the width of the interior of the tubular membrane. In forming the coil, a net separator is wound between the membrane layers of the coil. An inlet tube for one of the components communicates with one end of the membrane and an outlet tube for the same component communicates with the other end of the membrane. Means is provided for passing another of the components longitudinally of the coil between the membrane layers from one end of the coil to the other end. The specific embodiment of a blood oxygenator is described.
    Type: Grant
    Filed: January 20, 1978
    Date of Patent: December 5, 1978
    Assignee: Japan Foundation For Artificial Organs
    Inventors: Paul S. Malchesky, Yukihiko Nose
  • Patent number: 4127481
    Abstract: Extracorporeal and implantable blood interchange devices used in providing interchange function of predetermined components with a fluid, such as for instance the removal of undesirable components from the bloodstream of a human and, characterized by capillary tubing having a reactor or sorbent material, such as activated charcoal, disposed within the lumens thereof, with the tubing being semi-permeable and with blood, or other fluid, being perfused over the capillary tubing in close physical contact with the exterior surfaces thereof, for accomplishing interchange coaction between the sorbent in the tubing and the perfusing fluid. Such tubing is arranged in rectangular configuration, with tangential entry and exit of perfused fluid.
    Type: Grant
    Filed: January 5, 1978
    Date of Patent: November 28, 1978
    Assignee: Japan Foundation for Artificial Organs
    Inventors: Paul S. Malchesky, Yukihiko Nose