Patents Assigned to Johns Hopkins University, The
  • AEROSOL BIOSENSORS AND RELATED ASPECTS FOR PATHOGEN DETECTION
    Publication number: 20230341390
    Abstract: Provided herein are methods of detecting a pathogen, such as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in aerosol samples. Related devices, kits, systems, and computer program products are also provided.
    Type: Application
    Filed: May 18, 2021
    Publication date: October 26, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Chao WANG, Hongpeng JIA, Mukund Madhav Madhav GOYAL
  • METHODS AND RELATED ASPECTS FOR PATHOGEN DETECTION
    Publication number: 20230341396
    Abstract: Provided herein are methods of detecting pathogen antibodies, such as a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in samples. Related devices, kits, reaction mixtures, and systems are also provided.
    Type: Application
    Filed: September 13, 2021
    Publication date: October 26, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Netzahualcoyotl ARROYO, Jamie SPANGLER, Taekjip HA, Elissa Kathleen LEONARD, Miguel Aller PELLITERO, Soojung Claire HUR, Harrison KHOO
  • Identification of epigenomic reprogramming in cancer and uses thereof
    Patent number: 11795510
    Abstract: The present invention relates to a method of identifying epigenetic reprogramming. Identifying epigenetic reprogramming comprises detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 24, 2023
    Assignees: The Johns Hopkins University, Memorial Sloan Kettering Cancer Center, Vanderbilt University
    Inventors: Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
  • Personalized computation modeling of atrial fibrosis to guide catheter ablation of atrial fibrillation
    Patent number: 11793573
    Abstract: Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. A patient-specific model of the atria may be generated from the three-dimensional imaging data. Simulation of the AF on the patient-specific model may be conducted to identify AF-perpetrating regions. One or more ablation locations in the atria may be identified from the AF-perpetrating regions.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: October 24, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Natalia A. Trayanova, Kathleen Mcdowell
  • Steerable drill for minimally-invasive surgery
    Patent number: 11793526
    Abstract: An embodiment in accordance with the present invention provides a continuum dexterous manipulator (CDM) with a specially designed flexible tool, to be used as a handheld or robotic steerable device for treatment of hard-tissue-related diseases. The CDM of the present invention works well in treatment of soft and sticky material (similar to a lesion) as well as milling the hard tissues (e.g. sclerotic liner of osteolytic lesions) and bone tumors. The present invention is also directed to flexible drilling tools as well as characterization and evaluation of integrating these tools with the CDM in curved-drilling of hard bone towards treatment of hard tissue related diseases (e.g. osteonecrosis or pelvic fracture). The present invention can also include use of various types of drill geometries, aspiration and irrigation, and endoscope view in curved-drilling and trajectory planning.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: October 24, 2023
    Assignee: The Johns Hopkins University
    Inventors: Farshid Alambeigi, Mehran Armand
  • Method for metal artifact avoidance in x-ray imaging
    Patent number: 11790525
    Abstract: A system and method for metal artifact avoidance in 3D x-ray imaging is provided. The method includes determining a 3D location of metal in an object or volume of interest to be scanned; estimating a source-detector orbit that will reduce the severity of metal artifacts; moving an imaging system to locations consistent with the source-detector orbit that was estimated; and scanning the object according to the source-detector orbit.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: October 17, 2023
    Assignees: THE JOHNS HOPKINS UNIVERSITY, SIEMENS HEALTHCARE GMBH
    Inventors: Jeffrey H. Siewerdsen, Pengwei Wu, Niral M. Sheth, Bjoern W. Kreher
  • Wearable sensor
    Patent number: 11786153
    Abstract: A wearable sensor system includes a flexible patch, an electronic circuit disposed on the flexible patch, and a disposable sensor disposed on the flexible patch and connected to the electronic circuit via a socket. The disposable sensor detects a chemical compound. The electronic circuit generates a detection signal commensurate with the chemical compound detected by the disposable sensor. The disposable sensor is removably plugged into the socket, thereby permitting replacement of the disposable sensor upon satisfaction of a predetermined condition. A battery disposed is on the flexible patch and connected to the electronic circuit to power the electronic circuit. A transceiver is connected to the electronic circuit, wherein the transceiver transmits the detection signal.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: October 17, 2023
    Assignee: The Johns Hopkins University
    Inventors: Konstantinos Gerasopoulos, Julia B. Patrone, Leslie H. Hamilton, Luke J. Currano, Matthew A. Hagedon, Felix Connor Sage, Mekbib Astatke
  • Use of a global assay of coagulation and fibrinolysis to aide in thromboembolism
    Patent number: 11789030
    Abstract: The present invention provides methods for identification of subjects with a rise in plasma coagulability post-diagnosis of thrombotic event (and consequent increased risk for recurrent thromboembolism) as well as for identification of subjects without thrombotic event who exhibit a rise in plasma coagulability for which prophylactic anticoagulation may be warranted for TE prevention, and other methods for identification of perioperative subjects who are at heightened risk for perioperative bleeding and/or for requiring blood transfusion, using the CloFAL assay, to aid in clinical decision making regarding anticoagulant and/or adjunctive clinical management designed to mitigate this heightened thromboembolic risk.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: October 17, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Neil Goldenberg
  • METHODS, SYSTEMS, AND RELATED COMPUTER PROGRAM PRODUCTS FOR EVALUATING RESPIRATORY PATTERN
    Publication number: 20230320618
    Abstract: Provided herein are methods of evaluating cardio-respiratory function, including detecting diseases, disorders, or conditions in test subjects involving the identification of respiratory timing patterns in respiratory audio signals. Related systems and computer program products are also provided.
    Type: Application
    Filed: August 25, 2021
    Publication date: October 12, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Mudiaga SOWHO, Alexander BISANT, Daniel EVANS
  • COMPOSITIONS AND METHODS OF RNA ANALYSIS
    Publication number: 20230323428
    Abstract: The present disclosure relates to compositions and methods of RNA analysis. In particular, the present disclosure provides a method of RNA analysis that includes obtaining a sample, applying one or more multi-partite probes to the sample, where each of the one or more multi-partite probes includes at least two sub-probes, annealing at least one of the applied one or more multi-partite probes to at least one target nucleic acid within the sample, and ligating the at least two sub-probes associated with the at least one annealed multi-partite probe to create a target nucleic acid proxy that can be detected.
    Type: Application
    Filed: June 14, 2023
    Publication date: October 12, 2023
    Applicant: The Johns Hopkins University
    Inventors: Harry Benjamin Larman, Joel Credle
  • Influenza-activated constructs and methods of use thereof
    Patent number: 11781141
    Abstract: The presently disclosed subject matter provides a novel approach for the treatment, prevention, and diagnosis of Cap-Snatching virus infections, particularly all classes of human influenza, including pandemic influenza. The methods involve the use of constructs for RNA-interference (RNAi).
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: October 10, 2023
    Assignee: The Johns Hopkins University
    Inventors: Christopher E. Bradburne, Lucy M. Carruth
  • Electro-mechanically stretched micro fibers and methods of use thereof
    Patent number: 11779682
    Abstract: The presently disclosed subject matter provides a scalable and electrostretching approach for generating hydrogel microfibers exhibiting uniaxial alignment from aqueous polymer solutions. Such hydrogel microfibers can be generated from a variety of water-soluble natural polymers or synthetic polymers. The hydrogel microfibers can be used for controlled release of bioactive agents. The internal uniaxial alignment exhibited by the presently disclosed hydrogel fibers provides improved mechanical properties to hydrogel microfibers, and contact guidance cues and induces alignment for cells seeded on or within the hydrogel microfibers.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 10, 2023
    Assignee: The Johns Hopkins University
    Inventors: Sharon Gerecht, Shuming Zhang, Sebastian F. Barreto Ortiz, Hai-Quan Mao
  • Combination of immunotherapy with local chemotherapy for the treatment of malignancies
    Patent number: 11779555
    Abstract: The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: October 10, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Dimitrios Mathios, Betty Tyler, Drew Pardoll, Henry Brem, Michael Lim
  • Wideband radial line slot array antenna
    Patent number: 11784413
    Abstract: An antenna includes a waveguide defined by a gap between a backplane with radial support ribs and a facesheet, a teardrop-shaped feed pin at a center of the backplane, and a foam spacer between the backplane and facesheet. An outward facing side of the facesheet includes thermal paint. The facesheet includes pairs of through-hole slots for releasing portions of a wave of radiation in the waveguide to generate a transmit-beam or to receive the receive-beam to generate the wave of radiation. The pairs may be disposed as a spiral array about a center of the facesheet. Each of the pairs may include first and second slots. A length of the second slot is oriented approximately perpendicular to a length of the first slot. Dispositions of the slots are set by a computer process. The dispositions optimize a trade-off between transmit and receive gains.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: October 10, 2023
    Assignee: The Johns Hopkins University
    Inventor: Matthew G. Bray
  • Targeted epigenetic therapy against distal regulatory element of TGF?2 expression
    Patent number: 11771703
    Abstract: The instant disclosure provides methods and compositions for the diagnosis, treatment and prevention of a TGF?2-associated disease, disorder and/or condition, including, e.g., Scleroderma, other fibrotic disease, grade 4 glioblastoma (GBM) and/or Primary Open-Angle Glaucoma (POAG). The disclosure further provides pharmaceutical compositions and kits for the diagnosis, treatment and prevention of TGF?2-associated diseases, disorders and/or conditions.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: October 3, 2023
    Assignee: The Johns Hopkins University
    Inventors: Harry C. Dietz, Joseph Shin
  • Safe sequencing system
    Patent number: 11773440
    Abstract: The identification of mutations that are present in a small fraction of DNA templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. We here describe an approach that can substantially increase the sensitivity of massively parallel sequencing instruments for this purpose. One example of this approach, called “Safe-SeqS” for (Safe-Sequencing System) includes (i) assignment of a unique identifier (UID) to each template molecule; (ii) amplification of each uniquely tagged template molecule to create UID-families; and (iii) redundant sequencing of the amplification products. PCR fragments with the same UID are truly mutant (“super-mutants”) if ?95% of them contain the identical mutation.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: October 3, 2023
    Assignee: The Johns Hopkins University
    Inventors: Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Isaac A. Kinde
  • Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA)
    Patent number: 11773182
    Abstract: The presently disclosed subject matter provides compositions and methods comprising isolated antibodies that can recognize human prostate-specific membrane antigen (PSMA). The presently disclosed antibodies can be used to for imaging and therapy of PSMA-expressing cancers, such as prostate cancer, in a subject.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 3, 2023
    Assignees: The Johns Hopkins University, Institute of Biotechnology CAS, V.V.I.
    Inventors: Cyril Barinka, Martin G. Pomper, Zora Novakova, Catherine A. Foss
  • Nanofiber-hydrogel composites for cell and tissue delivery
    Patent number: 11771807
    Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: October 3, 2023
    Assignee: The Johns Hopkins University
    Inventors: Sashank Reddy, Russell Martin, Xiaowei Li, Calvin Chang, Kevin Colbert, Hai-Quan Mao
  • METHODS AND RELATED ASPECTS FOR ANALYZING CHROMOSOME NUMBER STATUS
    Publication number: 20230307130
    Abstract: Provided herein are methods of distinguishing between meiotic- and mitotic-origin aneuploidies in certain embodiments. Related systems and computer program products are also provided.
    Type: Application
    Filed: November 5, 2021
    Publication date: September 28, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Daniel ARIAD, Rajiv MCCOY, Manuel VIOTTI
  • Methods for enhancing antigen-specific immune responses
    Patent number: 11766478
    Abstract: Described herein are methods comprising administering to a mammalian subject an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at least one immunogenic antigen, thereby enhancing the antigen specific immune response relative to administration of the immunogenic antigen alone. Methods and kits for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a chemotherapeutic agent and boosting the mammal by administering to the mammal an effective amount of an annexin chimeric fusion.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: September 26, 2023
    Assignee: The Johns Hopkins University
    Inventors: Tzyy-Choou Wu, Chien-Fu Hung