Abstract: Provided are systems, compositions and methods that useful in any setting where generating and tracking light is used. The systems, methods and compositions contain as a component flexible, transparent membrane-based materials that include light emitting diodes (LEDs). The LEDs can include or be formed from colloidal quantum dots (CQDs) as an active layer. The CQDs can be formed from solution-processed semiconductor nanocrystals. They have a tunable band gap energy that can be readily tuned by adjusting the size of the nanocrystals. Transparent membrane-based LED arrays exhibit emission wavelength that can be tuned anywhere in the range of 800-2000 nm. The LEDs are highly transparent in the visible wavelength range with the exception of the CQD active layer. The CQD-based LEDs are components of any device or system wherein generating and/or tracking reflected light is utilized, such as in tracing the location and movement of a living individual, or an inanimate object.

Abstract: Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.

Abstract: Gel polymer electrolyte compositions including a cross-linked three-dimensional polymer network and an electrolyte composition comprising an electrolyte and water are disclosed. The gel polymer electrolyte compositions can be included in an aqueous electrochemical cell, in which a gel polymer electrolyte can be positioned between an anode and a cathode. Methods of forming a gel polymer electrolyte in the form of a film, and methods of forming an aqueous electrochemical cell including a gel polymer electrolyte, are also disclosed.

Abstract: In one example aspect, a system is disclosed that includes an image capture device; a capillaroscope attachable to the image capture device, the capillaroscope including: a light source configured to provide offset light at an angle and location offset from a center horizontal axis and produce oblique remitted light off a patient site; a reverse lens through which the oblique remitted light passes therethrough; and one or more telescopic lenses through which the remitted light passes therethrough to a lens of the image capture device after passing through the reverse lens.

Abstract: A system quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user.

Abstract: The presently disclosed subject matter provides compositions and methods for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.

Abstract: Provided herein are methods of generating models to predict prospective pathology scores of test subjects having a pathology in certain embodiments. Related systems and computer program products are also provided.

Abstract: A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas.

Abstract: The present invention provides a method of inducing cell death by hyperactivation of motility networks.

Abstract: The present invention provides a targeted nanoplex platform for in vivo imaging and theranostic imaging of cancer to simultaneously provide non-invasive assessment of tumor burden and cancer-selective treatments.

Abstract: A cooling device according to the present invention includes a housing configured to accommodate fungi. Warm air enters the housing through an inlet located in the housing. The air flows through the housing, which holds fungi. The air exits the housing and can be driven by an exhaust fan. In some embodiments, a HEPA filter is included to purify the air and prevent dispersal of fungal spores.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.

Abstract: A system includes: a phantom object; one or more sensors within the phantom object; and a processor, a computer readable memory, a non-transitory computer readable storage medium associated with a computing device in communication with the phantom object, and program instructions executable by the computing device to cause the computing device to perform operations including: detecting a medical instrument within the phantom object based on sensor data captured by the one or more sensors; measuring a distance between the medical instrument and a target point based on the sensor data; and storing or outputting information identifying the distance between the medical instrument and the target point.

Abstract: A computer-implemented method includes: receipt and accession of magnetic field data from a constellation of satellites providing global coverage over the Earth in a time span less than one day; inter-calibrating the magnetic field data from all satellites to a common standard; quantifying the global magnetic disturbance and selecting quiescent intervals at least as short as one day for evaluation of Earth's internally-generated field; calculating global maps of the mean vector magnetic field for each quiet interval from the average of all satellite measurements in angular bins; converting the time sequence of global maps of the mean fields to time series of angular harmonic coefficients via direct convolution; applying spectral and regression analysis to the harmonic coefficient time series to identify and remove artifacts in the signals; reconstructing a continuous time and spatial representation of the magnetic field continuous in time and angular position globally.

Abstract: The present disclosure is directed to a composition or combination comprising at least one membrane-active peptide, such as melittin, and at least one therapeutic and/or diagnostic agent. Methods of using the membrane-active peptides of the disclosure to open a blood-brain barrier and to deliver a therapeutic and/or a diagnostic agent to a central nervous system (CNS) of a subject in need thereof are also provided.

Abstract: Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.

Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.

Abstract: An embodiment in accordance with the present invention provides a miniature microscope capable of performing in vivo, real-time imaging of multiple organ sites in awake and behaving animals (e.g. rodents). A microscope according to the present invention includes multiple optical contrast mechanisms (i.e. contrast arising from neural, hemodynamic and other physiological components). Exemplary contrast mechanisms include, but are not limited to fluorescence, hemoglobin level, deoxyhemoglobin level, and blood flow. The microscope is fully adaptable to in vitro and ex vivo imaging, can be customized to concurrently image at variable magnifications, conduct optogenetic/electrical/chemical stimulations, drug delivery, microdialysis, accompanied by electrical signal recording, wireless image transmission and charging.

Abstract: Additive manufacturing processes, systems and three-dimensional articles include the formation of voxels and/or portions of three-dimensional articles with different properties relative to other voxels and/or portions. The processes generally include changing one or more laser beam parameters including power level, exposure time, hatch spacing, point distance, velocity, and energy density during the formation of selected voxels and/or portions of the three-dimensional articles. Also disclosed are processes that include an additive manufacturing process that provides localized secondary heat treatment of certain voxels and/or regions at a temperature below the melting point of the three-dimensional article but high enough to effect a localized property change.