Patents Assigned to K.K. Ueno Seiyaku Oyo Kenkyujo
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Patent number: 5428062Abstract: The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E.Therefore, the novel 13,14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.Type: GrantFiled: April 28, 1993Date of Patent: June 27, 1995Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
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Patent number: 5380709Abstract: The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.Type: GrantFiled: April 28, 1993Date of Patent: January 10, 1995Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
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Patent number: 5246964Abstract: A method of treatment of inflammatory diseases which comprises administering, to a subject in need of such treatment, an anti-inflammatory effective amount of a polyoxyethylenesorbitan mono-higher-fatty acid ester.Type: GrantFiled: July 8, 1991Date of Patent: September 21, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventor: Ryuji Ueno
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Patent number: 5234954Abstract: A method for treatment of hyperlipemia which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount, effective in decreasing lipid concentration in the blood.Type: GrantFiled: June 15, 1992Date of Patent: August 10, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuji Ueno, Hiroyoshi Osama
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Patent number: 5225439Abstract: The novel 13, 14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advatage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13, 14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.Type: GrantFiled: April 5, 1991Date of Patent: July 6, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
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Patent number: 5221799Abstract: A compound of the formula: ##STR1## wherein L and M are hydrogen atom, hydroxy, lower alkyl, hydroxy(lower)alkyl or oxo, provided that at least one of L and M is not hydrogen atom and that the five-membered ring may have one or two double bonds,X.sub.1 and X.sub.2 are hydrogen atom, halogen atom or lower alkyl,Y is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C-- or --CO--CH.sub.2 --,Z is --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--CH.sub.2 or --CH.sub.2 --CH.dbd.CH--,R is hydrogen atom, lower alkyl, lower cycloalkyl, monocyclic aryl, monocyclic aryl(lower)alkyl or monocyclic aroyl(lower)alkyl,R.sub.2 is single bond or lower alkylene,R.sub.Type: GrantFiled: July 30, 1992Date of Patent: June 22, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuji Ueno, Tomio Oda
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Patent number: 5194429Abstract: The present invention relates to an ocular hypotensive composition and a composition for treatment of glaucoma which comprising an amount of 20-substituted-PGs or 20-substituted-15-keto-PGs effective as an ocular hypotensive agent; these compounds exhibit no or little side effects such as transient ocular hypertensive response, hyperemia of conjunctiva or of iris, dacryops, lema, closed eye and the like.Type: GrantFiled: November 19, 1990Date of Patent: March 16, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
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Patent number: 5185374Abstract: A method of inducing uterine contraction which comprises administering, to a subject in need of such contraction, a uterine-contractionally effective amount of a prostanoic acid derivative selected from the group consisting ofa) 15-ketoprostaglandin E compounds, andb) 15-ketoprostaglandin F compounds with the proviso that when the only one group, which is unsubstituted n-pentyl group, is attached to the carbon atom at the 15-position of the prostanoic acid nucleus and the bond between the carbon atoms at 5- and 6-positions is a double bond, then the bond between the carbon atoms at 13- and 14-positions is a single bond.Type: GrantFiled: April 22, 1991Date of Patent: February 9, 1993Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
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Patent number: 5175189Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of(a) a 15-ketoprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and(b) a sympathomimetic agent in an amount effective in treatment of ocular hypertension.Type: GrantFiled: June 15, 1992Date of Patent: December 29, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventor: Ryuji Ueno
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Patent number: 5169863Abstract: This invention provides a hypersphyxia-causing composition containing 15-keto-PGEs esters separated from any substantial activity such as decrease of blood pressure.The present invention provides a hypersphyxia-causing composition effective to recovery of blood pressure, and heart rate in e.g. hemmorrhage shock, or hyperventilation, which comprises 15-keto PGEs esters.Type: GrantFiled: March 22, 1991Date of Patent: December 8, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
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Patent number: 5166174Abstract: The novel 13,14-dihydro-15-keto prostaglandins E of the invention have remarkable preventive effects against ulcers. Further, the novel 13,14-dihydro-15-keto-prostaglandins E of the invention have an advantage that they have none of side effects which prostaglandin E intrinsically has, or can remarakably reduce such effects of the prostaglandin E. Therefore, the novel 13,14-dihydro-15-keto prostaglandins E of the invention are effective for animal and human use for treatment and prevention of ulcers, such as duodenal ulcer and gastric ulcer.Type: GrantFiled: May 13, 1991Date of Patent: November 24, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
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Patent number: 5166175Abstract: A method for treatment of ocular hypertension which comprises oculary administering, to a subject in need of such treatment, a oculo-hypotensively synergistic combination of(a) a 13,14-dihydro-15-ketoprostaglandin compound, and(b) a .beta.-adrenergic blockerin an amount effective in treatment of ocular hypertension.Type: GrantFiled: May 21, 1991Date of Patent: November 24, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventor: Ryuji Ueno
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Patent number: 5166178Abstract: The present invention relates to ocular hypotensive agents which contains 13,14-dihydro-15-keto-prostagrandins, which shows no transient ocular hypertensive response that PGs usually show.Type: GrantFiled: September 16, 1991Date of Patent: November 24, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno
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Patent number: 5164415Abstract: A method of treatment of pancreatic disease which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective in treatment of pancreatic disease.Type: GrantFiled: April 30, 1991Date of Patent: November 17, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventor: Ryuji Ueno
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Patent number: 5162370Abstract: A method for treatment of cataract which comprises administering, to a subject in need of such treatment, a prostacyclin compound in an amount effective in treatment of cataract.Type: GrantFiled: August 1, 1991Date of Patent: November 10, 1992Assignee: K. K. Ueno Seiyaku Oyo KenkyujoInventor: Ryuji Ueno
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Patent number: 5151444Abstract: The present invention relates to ocular hypotensive agents which contains 13,14-dihydro-15-keto-prostagandins, which shows no transient ocular hypertensive response that PGs usually show.Type: GrantFiled: September 19, 1990Date of Patent: September 29, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Oda
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Patent number: 5137915Abstract: The present invention provides novel prostaglandins D, that is, 13,14-dihydro-15-keto-PGDs, which have an excellent sedative and sleep-inducing activity, and so they are useful for tranquilizer and/or soporifics.Type: GrantFiled: June 13, 1991Date of Patent: August 11, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Ichie Kato, Tomio Oda
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Patent number: 5128060Abstract: A new oxygen absorbent which is used sealed in a pack with a food to prevent the food from deteriorating is disclosed, in which the oxygen absorbent contains ascorbic acid and/or salts thereof, an alkaline compound such as sodium carbonate, a reaction accelerator such as ferrous sulfate, and a silica gel, and improves the flowability and the oxygen absorbability.Type: GrantFiled: May 13, 1991Date of Patent: July 7, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Akihiko Tabata
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Patent number: 5126372Abstract: A method for improvement of excretion of nonprotein nitrogen into the intestines which comprises administering, to a subject in need of such improvement, a prostanoic acid derivative in an amount effective in improving excretion of nonprotein nitrogen into the intestines.Type: GrantFiled: August 8, 1990Date of Patent: June 30, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuji Ueno, Hiroyoshi Osama
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Patent number: 5117042Abstract: A method of treatment for improving encephalic function which comprises administering, to a subject in need of such treatment, a 15-keto-prostaglandin compound in an amount effective for improvement of encephalic function.Type: GrantFiled: November 21, 1990Date of Patent: May 26, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuji Ueno, Hiroyoshi Osama, Tomio Oda