Patents Assigned to KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION
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Publication number: 20210208148Abstract: One embodiment of this invention is a method for confirming expression of the PRDM14 gene from blood or lymphatic fluid collected from a subject by: (1) detecting PRDM14 positive CTC which expresses the PRDM14 gene; or (2) measuring the concentration of at least one protein selected from the group consisting of leptin receptor (LEPR), macrophage-derived chemokine (MDC) and gamma-interferon (IFN?).Type: ApplicationFiled: September 25, 2018Publication date: July 8, 2021Applicants: The University of Tokyo, Kanagawa Prefectural Hospital OrganizationInventors: Kohzoh Imai, Hitoshi Zembutsu, Hiroaki Taniguchi, Anri Saitoh, Yohei Miyagi
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Patent number: 10004718Abstract: The present invention provides an erythropoietin expression-enhancing agent that can cancel the suppression of erythropoietin production or promote erythropoietin production, and a therapeutic or preventive drug for anemia, a liver function-improving agent, an ischemic injury-improving agent, a renal protective agent, and an insulin secretagogue comprising the erythropoietin expression-enhancing agent. The erythropoietin expression-enhancing agent of the present invention comprises one or more compounds selected from the group consisting of compounds represented by the following general formulas (I), (II), and (III) and pharmaceutically acceptable salts thereof when R3 is OH.Type: GrantFiled: November 25, 2013Date of Patent: June 26, 2018Assignees: Tohoku University, Kake Education Institution, Kanagawa Prefectural Hospital Organization Kanagawa Children's Medical CenterInventors: Takaaki Abe, Teiji Tominaga, Kenichiro Hayashi, Hitoshi Osaka
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Patent number: 9932625Abstract: The invention provides a method for detection of mutant-type DNA or/and wild-type DNA by contacting at least one of a single-stranded DNA having a substituted nucleotide, a deficient nucleotide region, or an inserted nucleotide region (mutant-type DNA), or/and a wild-type single-stranded DNA corresponding to the mutant-type DNA (wild-type DNA) with a probe hybridizing with both single-stranded DNAs, to form a hybrid with the mutant-type DNA (mutant-type hybrid) or/and a hybrid with the wild-type DNA (wild-type hybrid) (at least one of the obtained mutant-type hybrid and wild-type hybrid has a loop structure), (2) contacting the obtained mutant-type hybrid or/and wild-type hybrid with an intercalator, and (3) detecting the presence or absence of the mutant-type DNA or/and the wild-type DNA by separating the conjugate of mutant-type hybrid and intercalator or/and the conjugate of wild-type hybrid and intercalator.Type: GrantFiled: March 22, 2013Date of Patent: April 3, 2018Assignees: WAKO PURE CHEMICAL INDUSTRIES, LTD., KANAGAWA PREFECTURAL HOSPITAL ORGANIZATIONInventors: Shoichi Matsukuma, Tomokazu Ishikawa, Tatsuo Kurosawa
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Publication number: 20180057553Abstract: A technique is provided which enables simple and low-cost purification of biologically active proteins by means of a conjugate of a target substance capturing molecule and a protein which comprises the amino acid sequence in SEQ ID NO:1, or a protein which comprises the amino acid sequence obtained by deleting, substituting or adding one or multiple amino acids in the amino acid sequence in SEQ ID NO: 1 and which has binding activity to a compound having —OH or —OR1 [R1 represents a hydrogen atom, an alkyl group or —PO3H2].Type: ApplicationFiled: March 4, 2016Publication date: March 1, 2018Applicants: The University of Tokyo, Kanagawa Prefectural Hospital OrganizationInventors: Kohzoh IMAI, Shotaro TSUJI
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Patent number: 9834813Abstract: The present invention relates to a method for detecting of a mutant DNA using a probe, comprising: (1) contacting a sample containing a single-stranded DNA which has a substituted nucleotide, a deleted nucleotide region, or an inserted nucleotide region (mutant-type DNA), or/and a wild-type single-stranded DNA (wild-type DNA) corresponding thereto with the probe which hybridizes with both single-stranded DNA, to form a hybrid with the mutant-type DNA (mutant-type hybrid) or/and a hybrid with a wild-type DNA (wild-type hybrid), wherein at least one of the obtained mutant-type hybrid and wild-type hybrid has the stem structure; (2) separating the obtained mutant-type hybrid or/and wild-type hybrid by electrophoresis on the basis of presence or absence of the stem structure or difference in the stem structure; and (3) detecting the presence or absence of the mutant-type DNA in the sample.Type: GrantFiled: September 22, 2011Date of Patent: December 5, 2017Assignees: Wako Pure Chemical Industries, Ltd., Kanagawa Prefectural Hospital OrganizationInventors: Shoichi Matsukuma, Tomokazu Ishikawa
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Publication number: 20170049870Abstract: The present application relates to an antigen peptide derived from the sequence of epidermal growth factor receptor having T790M point mutation and a pharmaceutical composition for the treatment of cancer comprising the peptide.Type: ApplicationFiled: October 21, 2016Publication date: February 23, 2017Applicant: Kanagawa Prefectural Hospital OrganizationInventors: Tetsuro Sasada, Tetsuya Nakatsura, Kazuya Ofuji
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Patent number: 9505824Abstract: The present application relates to an antigen peptide derived from the sequence of epidermal growth factor receptor having T790M point mutation and a pharmaceutical composition for the treatment of cancer comprising the peptide.Type: GrantFiled: August 8, 2013Date of Patent: November 29, 2016Assignee: Kanagawa Prefectural Hospital OrganizationInventors: Tetsuro Sasada, Tetsuya Nakatsura, Kazuya Ofuji
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Patent number: 9454642Abstract: The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group.Type: GrantFiled: July 2, 2011Date of Patent: September 27, 2016Assignees: NEC Solution Innovators, Ltd., KANAGAWA PREFECTURAL HOSPITAL ORGANIZATIONInventors: Jou Akitomi, Shintarou Katou, Shotaro Tsuji, Iwao Waga
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Patent number: 9278108Abstract: A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10?7 or less can be used as the nucleic acid molecule that can bind to HMGB1 protein. The HMGB1 binding nucleic acid molecule can bind to HMGB1 protein that is known to be a cause of diseases such as cancer and inflammation, and it is therefore possible to obtain an effect to prevent and an effect to treat such diseases by allowing the HMGB1 binding nucleic acid molecule to bind to HMGB1 protein in a living body.Type: GrantFiled: July 16, 2010Date of Patent: March 8, 2016Assignees: NEC Solution Innovators, Ltd., Kanagawa Prefectural Hospital OrganizationInventors: Hiromi Takenaka, Jou Akitomi, Shintarou Katou, Shotaro Tsuji, Takashi Ohtsu, Iwao Waga
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Publication number: 20150218248Abstract: The present application relates to an antigen peptide derived from the sequence of epidermal growth factor receptor having T790M point mutation and a pharmaceutical composition for the treatment of cancer comprising the peptide.Type: ApplicationFiled: August 8, 2013Publication date: August 6, 2015Applicant: Kanagawa Prefectural Hospital OrganizationInventors: Tetsuro Sasada, Tetsuya Nakatsura, Kazuya Ofuji
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Publication number: 20150050749Abstract: The invention provides a method for detection of mutant-type DNA or/and wild-type DNA by contacting at least one of a single-stranded DNA having a substituted nucleotide, a deficient nucleotide region, or an inserted nucleotide region (mutant-type DNA), or/and a wild-type single-stranded DNA corresponding to the mutant-type DNA (wild-type DNA) with a probe hybridizing with both single-stranded DNAs, to form a hybrid with the mutant-type DNA (mutant-type hybrid) or/and a hybrid with the wild-type DNA (wild-type hybrid) (at least one of the obtained mutant-type hybrid and wild-type hybrid has a loop structure), (2) contacting the obtained mutant-type hybrid or/and wild-type hybrid with an intercalator, and (3) detecting the presence or absence of the mutant-type DNA or/and the wild-type DNA by separating the conjugate of mutant-type hybrid and intercalator or/and the conjugate of wild-type hybrid and intercalator.Type: ApplicationFiled: March 22, 2013Publication date: February 19, 2015Applicants: WAKO PURE CHEMICAL INDUSTRIES, LTD., KANAGAWA PREFECTURAL HOSPITAL ORGANIZATIONInventors: Shoichi Matsukuma, Tomokazu Ishikawa, Tatsuo Kurosawa
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Publication number: 20150050649Abstract: The invention provides a method of detecting DNA having a microsatellite region without causing the problem of a non-specific reaction product. The method includes (1) contacting a probe, which does not have a nucleotide sequence complementary to the microsatellite region and hybridizes with both sides of the nucleotide sequences of the microsatellite region, with DNA having the microsatellite region, to form a hybrid of the DNA and the probe, which has a loop structure including a microsatellite region, (2) separating the obtained hybrid, (3) detecting the hybrid. The invention also provides a hybrid of DNA and a probe, having a loop structure including a microsatellite region, which is made by contacting DNA having a microsatellite region with the probe which does not have a nucleotide sequence complementary to the microsatellite region, and hybridizes with both sides of the nucleotide sequence of the microsatellite region.Type: ApplicationFiled: March 22, 2013Publication date: February 19, 2015Applicants: WAKO PURE CHEMICAL INDUSTRIES, LTD., KANAGAWA PREFECTURAL HOSPITAL ORGANIZATIONInventors: Shoichi Matsukuma, Tomokazu Ishikawa, Tatsuo Kurosawa
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Patent number: 8822667Abstract: The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).Type: GrantFiled: July 26, 2011Date of Patent: September 2, 2014Assignees: NEC Solution Innovators, Ltd., Kanagawa Prefectural Hospital OrganizationInventors: Naomi Hirabayashi, Shotaro Tsuji, Jou Akitomi, Shintarou Katou, Iwao Waga, Takashi Ohtsu
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Publication number: 20130123350Abstract: The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2).Type: ApplicationFiled: July 26, 2011Publication date: May 16, 2013Applicants: KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION, NEC SOFT, LTD.Inventors: Naomi Hirabayashi, Shotaro Tsuji, Jou Akitomi, Shintarou Katou, Iwao Waga, Takashi Ohtsu
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Publication number: 20130102480Abstract: The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group.Type: ApplicationFiled: July 2, 2011Publication date: April 25, 2013Applicants: KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION, NEC SOFT, LTD.Inventors: Jou Akitomi, Shintarou Katou, Shotaro Tsuji, Takashi Ohtsu, Iwao Waga
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Publication number: 20120129720Abstract: An aptamer capable of binding to a histidine peptide is provided.Type: ApplicationFiled: May 14, 2010Publication date: May 24, 2012Applicant: KANAGAWA PREFECTURAL HOSPITAL ORGANIZATIONInventors: Shotaro Tsuji, Jou Akitomi, Shintarou Katou, Iwao Waga, Takashi Ohtsu