Abstract: A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.

Abstract: A composite powder comprising powder particles is disclosed. Each powder particle comprises a core element and a diffusion layer at least partially surrounding the core element. The core element comprises copper, gold or silver and an alloy element capable of forming a nitride, a carbide or a carbonitride. The diffusion layer comprises the alloy element and a nitride, carbide or carbonitride compound. The nitride, carbide or carbonitride compound comprises the alloy element.

Abstract: A method for forming a modified resonator is provided. In one aspect, the method includes obtaining a resonator on top of a substrate, thereby forming an interface area between a bottom surface of the resonator and a top surface of the substrate. The resonator can include niobium or tantalum. The method also includes contacting the resonator and the substrate with a liquid acidic etching solution selected so as to have a higher etch rate towards the substrate than towards the resonator and a nonzero etch rate towards the resonator.

Abstract: This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Abstract: A method is provided for indoor multipath ghosts recognition for a multiple-input-multiple-output radar with collocated antennas. The method includes the step of generating a two-dimensional Range-Doppler map for N number of consecutive radar data frames. The method further includes the step of applying a temporal clustering algorithm to the N number of consecutive radar data frames. Moreover, the method includes the step of applying a linear pattern extraction algorithm on the two-dimensional Range-Doppler map. In this context, the two-dimensional Range-Doppler map comprises detections from at least one target, at least one first-order ghost, and at least one second-order ghost with respect to one wall reflector.

Abstract: The invention describes chimeric Flavivirus constructs comprising lyssavirus G proteins in the E/NS1 intergenic region.

Abstract: A computer-implemented method for training a classifier (??), including: training a pretext model (??) to learn a pretext task, so as to minimize a distance between an output of a source sample via the pretext model (??) and an output of a corresponding transformed sample via the pretext model (??), the transformed sample being a sample obtained by applying a transformation (T) to the source sample; S20) determining a neighborhood (NXi) of samples (Xi) of a dataset (SD) in the embedding space; S30) training the classifier (??) to predict respective estimated probabilities ??j(Xi), j=1 . . . C, for a sample (Xi) to belong to respective clusters (Cj), by using a second training criterion which tends to: maximize a likelihood for a sample and its neighbors (Xj) of its neighborhood (Nxi) to belong to the same cluster; and force the samples to be distributed over several clusters.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A system for image completion is disclosed. The system comprises a coordinate generation module configured to receive past frames and a present frame having a first field-of-view and to generate a set of coordinate maps, one for each of the received past frames; and a frame aggregation module configured to receive as input the past frames, the present frame, and the coordinate maps and to synthesize, based on said input, a present frame having a second field-of-view.

Abstract: The present invention relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Stargardt disease.

Abstract: The present invention is in the field of a device comprising an adaptable and addressable neuromorphic structure, a method of operating said neuromorphic structure, a method of acquiring a distribution of states of said neuromorphic structure, and a method of adapting a micro-electronic or nano-electronic device comprising said neuromorphic structure.

Abstract: A semiconductor cell culture device for three-dimensional cell culture comprises: a semiconductor material layer in which a cell culture portion of semiconductor material is defined, wherein the cell culture portion defines an area within the semiconductor material layer surrounded by semiconductor material, wherein the cell culture portion comprises a mesh structure having island structures being interconnected by bridge structures and defining through-pores between the island structures allowing for selective transport of cell constructs, cellular components, proteins or other large molecules through the semiconductor material layer and on opposite sides of the cell culture portion in the semiconductor material layer, and a supporting structure connected to the cell culture portion.

Abstract: The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

Abstract: The invention relates to devices for the culture of cellular aggregates A comprising a three-dimensional network of interconnected vessels of a biocompatible liquid- and gas-permeable photo polymerised material, wherein the three-dimensional network is connected to a plurality of inlets and a plurality of outlets for the delivery of liquids, and overlayed with a secondary hydrogel network wherein the cellular aggregates are embedded. Herein defined vessels within the three-dimensional network are blocked, thereby defining at least one spatially segregated network within and structurally in contact with the three-dimensional network, wherein the at least one spatially segregated network is connected to a separate inlet and a separate outlet, allowing the supply of a liquid to a subregion within the three-dimensional network.

Abstract: The present disclosure relates generally to an improved gene expression system in the field of recombinant gene expression. The invention relates to a system showing an improved yield and quality of protein production and methods for increasing production of a protein produced by cultured cells, particularly cultured eukaryotic cells.

Abstract: The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: A wireless mesh network of nodes includes at least one relay node, the at least one relay node being configured to receive a first signal, the first signal corresponding to a first symbol comprised in a data frame, the first symbol having a first symbol duration s; and to generate and transmit a second signal, the second signal corresponding to the first signal. The first signal and the second signal are modulated such that a sum of the first signal and the second signal is capable of being received and demodulated by at least one relay node so as to obtain a sum of symbols including the first symbol and the second symbol.

Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: The present invention relates to a process for recovering platinum group metals from a feed containing one or more precursor compounds of one or more platinum group metal ions, wherein the process comprises the steps of (i) supplying to a cathode compartment of an electrochemical cell equipped with a cathode comprising a gas diffusion electrode with a porous electrochemically active material, the feed containing the one or more precursor compounds to form a liquid phase in the cathode compartment, (ii) supplying a CO2 containing gas to the cathode compartment, (iii) applying a potential to the cathode which is such as to cause electrochemical reduction of the CO2 to CO, (iv) and recovering from the liquid phase precipitated particles of the one or more platinum group metals in clemental form.

Abstract: A method for adjusting an information system of a mobile machine, the information system being configured to calculate 3D information relative to a scene in which the mobile machine is moving, the method including: acquiring at least a first image of the scene at a first time and a second image of the scene at a second time; detecting one or more scene features in the first image and the second image; matching the one or more scene features across the first image and the second image based upon detection of the one or more scene features; estimating an egomotion of the mobile machine based upon the matching of the one or more scene features across the first image and the second image; and adjusting the information system by taking into account the estimation of the egomotion of the mobile machine.