Patents Assigned to KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST
  • Patent number: 10799501
    Abstract: Provided herein is a pharmaceutical combination comprising (a) a poly-(ADP-ribose)-polymerase (PARP) inhibitor and (b) a second agent comprising (i) an inhibitor of glycogen synthase kinase 3 (GSK-3) or (ii) an inhibitor of disrupter of telomeric silencing 1-like (DOT1L). Also provided is a method of treating a subject suffering from acute myeloid leukaemia, comprising administering to the subject a therapeutically effective amount of the pharmaceutical combination.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: October 13, 2020
    Assignee: King's College Hospital NHS Foundation Trust
    Inventor: Chi Wai Eric So
  • Publication number: 20170156627
    Abstract: Particular aspects of the invention are methods for assaying metabolite levels in samples from a patient during pregnancy using nuclear magnetic resonance and direct flow injection mass spectrometry. In various methods, the assayed metabolites may be acylcarnitine or one or more of C3-OH (hydroxypropionylcarnitine), C5-OH (C3DC), C10, C5:1-DC (glutaconylcarnitine), C14:1-OH (hydroxytetradecenoylcarnitine) and C14:2-OH. One or more methods also may include measuring nuchal translucency of the fetus. Other methods relate to predicting fetal congenital heart defects in a fetus.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 8, 2017
    Applicants: BIOSCREENING AND DIAGNOSTICS LLC, KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST
    Inventors: Ray O. Bahado-Singh, Kypros Nicolaides
  • Publication number: 20160320395
    Abstract: The invention relates to materials and methods for diagnosing liver tumor types, and assessing patient prognosis. Specifically, but not exclusively, the invention concerns the determination of marker protein which enable primary liver tumors to be identified and classified according to the latest WHO classification. Particularly, the invention provides potential markers proteins which allow non-neoplastic and neoplastic hepatocytes and biliary epithelial cells to be distinguished. This allows grading of tumor differentiation to be refined and differential diagnosis of primary liver tumors and pathogenesis of sub-types of cholangiocarcinoma.
    Type: Application
    Filed: November 13, 2014
    Publication date: November 3, 2016
    Applicants: Electrophoretics Limited, King's College Hospital NHS Foundation Trust
    Inventors: Malcolm Andrew Ward, Ian Hugo Pike, David James Britton, Vikram Mitra, Nigel David Heaton, Yoh Zen, Alberto Quaglia
  • Publication number: 20160195536
    Abstract: The present invention concerns materials and methods relating to pancreatic cancer and personalized medicine as applied to pancreatic cancer. Particularly, the invention relates to materials and methods for the determination of significantly modulated protein phosphorylation and/or expression as well as the activity of signalling pathways collectively providing a tumour profile that can guide selection of the most appropriate treatment regime based on the likelihood of tumour recurrence or the identity of activated drug targets in pancreatic cancer.
    Type: Application
    Filed: August 13, 2014
    Publication date: July 7, 2016
    Applicants: Electrophoretics Limited, King's College Hospital NHS Foundation Trust
    Inventors: Yoh Zen, Nigel Heaton, Alberto Quaglia, David Britton, Malcolm Ward, Ian Pike, Vikram Mitra
  • Publication number: 20130078243
    Abstract: This invention relates to a therapeutic molecule capable of suppressing an immune response against an organ or tissue transplantation in a patient. In particular, the invention relates to a conjugate comprising a first portion connected to a second portion, wherein the first portion binds to an MHC Class I molecule and the second portion has HLA-G activity. This conjugate may be used as a medicament to modulate immune responses and induce immunological tolerance specific to allogenic MHC complexes.
    Type: Application
    Filed: November 11, 2010
    Publication date: March 28, 2013
    Applicant: King's College Hospital NHS Foundation Trust
    Inventor: Mohammad Ibrahim
  • Publication number: 20110229055
    Abstract: A phantom for determining the alignment of two or more imaging apparatuses. The phantom comprises a vessel, wherein a cavity is defined by the inner surfaces of the vessel. The cavity is for holding a fluid therein. Two or more rods extend through the cavity, the rods being non-parallel with one another.
    Type: Application
    Filed: June 23, 2008
    Publication date: September 22, 2011
    Applicant: KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST
    Inventor: Gillian Clarke