Abstract: The present invention provides a complex of LNA probe and graphene oxide, and a nucleic acid detection method using the same. In the present invention, LNA-containing molecular beacon is conjugated through covalent bonding with graphene oxide, a single strand of the molecular beacon binds to a target nucleic acid to form a complex, and the complex is separated from graphene oxide to induce a fluorescence signal. The molecular beacon and graphene oxide can be covalently bonded to minimize non-specific signals, and a LNA-added molecular beacon is designed in a double strand to detect a very low concentration of target nucleic acid with high sensitivity, as well as a fluorescent signal, and the multiple target nucleic acids can be detected simultaneously through diversification of the fluorescent signal to enable easy and accurate detection of a nucleic acid biomarker whose specific expression level is specifically changed according to diseases and disease progression.

Abstract: The present invention relates to a pharmaceutical composition comprising a DUSP1 inhibitor. The pharmaceutical composition comprising the DUSP1 inhibitor according to the present invention can solve the problems of inhibitors that target the active site because it inhibits DUSP1 by an allosteric inhibitory mechanism, and is effective for preventing or treating diseases involving DUSP1 enzymes, for example, a cancer such as a liver cancer, a breast cancer and a pancreatic cancer, a hepatitis C, and a depression. In particular, the DUSP1 inhibitor according to the present invention is very effective in treating a depression because it directly acts on neuronal growth.

Abstract: Disclosed is a catalyst for producing the olefin. The catalyst includes a support including alumina and a sub-support component, and a metal oxide impregnated on the support. The metal oxide includes anyone selected from an oxide of chromium, vanadium, manganese, iron, cobalt, molybdenum, copper, zinc, cerium and nickel; and the sub-support component includes anyone selected from zirconium, zinc and platinum.

Abstract: Provided is a method for treating or preventing cancer, containing, as an active ingredient, a compound having a specific chemical structure and an activity of inhibiting the formation of a c-Myc/Max/DNA complex, or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a catalyst for producing olefin and a preparation method thereof. The catalyst for producing olefin includes: a support including an alumina and a sub-support component; and a catalytic component comprising a metal component and an alkali metal impregnated on the support. The preparation method includes: providing a support comprising a sub-support component and an alumina; preparing pre-catalyst by dipping a metal component oxide in the support and calcining it; and dipping a metal component oxide and an alkali metal oxide in the pre-catalyst and calcining it.

Abstract: The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

Abstract: The present disclosure relates to a method for preparing an aramid nanofiber dispersion. More specifically, the present invention relates to a method for preparing aramid nanofibers in a short time from aromatic polyamide-based polymers other than fibers, and to aramid nanofibers prepared therefrom.

Abstract: Disclosed is a small animal intraventricular injection compensator for injecting a drug into a desired location through a syringe, the compensator including: a guide part provided with a guide hole into which a needle of a syringe is inserted; a body comprising an upper cavity provided inside thereof and a cradle provided to seat the guide part on an upper side thereof; and a fixation part integrally provided with the body or separately provided, and comprising a lower cavity provided to allow a head accommodation space, which a head of a small animal may enter into or exit from, to be provided inside thereof by corresponding to the upper cavity.

Abstract: A pyrimidine derivative compound of Chemical Formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a composition for preventing or treating cancer comprising the same as an active ingredient. The pyrimidine derivative compound of Chemical Formula 1, the optical isomer thereof, or the pharmaceutically acceptable salt thereof has an excellent selective inhibitory effect especially against TYRO 3 among TAM receptor inhibitory effects, and thus can be used as an excellent composition of preventing or treating cancer without adverse effects resulting from the inhibition of Axl and Mer.

Abstract: The present disclosure pertains to a recombinant Corynebacterium glutamicum strain for production of glutaric acid and a method for production of glutaric acid by using the same. When used to produce glutaric acid, the recombinant Corynebacterium glutamicum strain guarantees an excellent output and allows the selective production of glutaric acid without generation of byproducts, which needs no isolation and purification processes and thus leads to an economical benefit. Consequently, the recombinant strain is useful for production of glutaric acid.

Abstract: The present invention relates to a novel cathode buffer layer material, and an organic or organic/inorganic hybrid photoelectric device comprising same, and, if a novel compound of the present invention is applied to a cathode buffer layer of an organic photoelectric device such as organic solar cells, organic photodiode, colloidal quantum dot solar cell, and perovskite solar cell, a surface property of an electron transfer layer is improved via a high dipole moment of the novel compound, an electron can be easily extracted from a photoactive layer to a cathode electrode, and series resistance and leakage current can be reduced, thereby having a useful industrial effect, as performance of the organic or organic/inorganic hybrid photoelectric device being manufactured, such as an organic solar cell, organic photodiode, colloidal quantum dot solar cell, and perovskite solar cell, can be significantly improved.

Abstract: A method of manufacturing a porous composite electrode including: preparing an ink including a carbon material and a binder; coating a substrate with the ink to manufacture a composite electrode; and irradiating the composite electrode with microwave to remove the binder and an organic material, and a method of removing an organic material of a porous composite electrode.

Abstract: An apparatus for observing image of living tissue having a first cover slip and a second cover slip; and one or more chambers interposed between the first cover slip and the second cover slip and having a cavity therein; in order to observe a living tissue loaded in the cavity of the chamber above is provided. The apparatus for observing image of living tissue of the present invention can be easily prepared with a simple process and a low cost, and facilitates the observation of images of living tissues on both sides, so that an entire image of a huge living tissue at the level of several hundred micrometers can be obtained by using a tissue transparency technique, which is a distinguished advantage of the apparatus of the invention. In the apparatus of the invention, the outer wall part forming the chamber is strongly bound so that the leakage of the mounting solution and the bubble generation can be prevented, indicating the damage of the living tissue can also be prevented.

Abstract: The present invention relates to a method for preparing a BaSnO3 thin film, comprising the steps of: a) precipitating an amorphous precipitate by adding an alkaline aqueous solution to a mixture solution comprising a barium salt, a tin salt, hydrogen peroxide, and an organic acid; b) preparing a crystalline BaSnO3 precursor material by preheating the mixture solution containing the amorphous precipitate; c) preparing a dispersion solution by dispersing the crystalline BaSnO3 precursor material in a polar organic solvent; d) coating the dispersion solution on a substrate; and e) preparing a BaSnO3 thin film of a perovskite structure by heat treating the dispersion solution coated on the substrate.

Abstract: The present invention relates to a reactor for non-oxidative direct conversion of methane and a method of manufacturing ethylene and an aromatic compound using the same. More particularly, the present invention relates to a reactor for non-oxidative direct conversion of methane in which a catalytic reaction velocity is maximized, the production of coke is minimized, and a high conversion rate of methane and a high yield of ethylene and an aromatic compound are ensured when ethylene and the aromatic compound are manufactured from methane, and a method of manufacturing ethylene and an aromatic compound using the same.

Abstract: Provided are a novel [1,2,4]triazolo[4,3-a]quinoxaline derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating bromodomain extra-terminal (BET) protein-related diseases including cancer and autoimmune diseases, containing the same as an active ingredient.

Abstract: The present invention relates to a catalyst for preparing a light olefin, a preparation method therefor, and a method for preparing a light olefin by using same, and can provide a catalyst for preparing a light olefin, a preparation method therefor, and a method for preparing a light olefin by using same, the catalyst comprising a porous zeolite, a clay, an inorganic oxide binder, and Ag2O and P2O5 which are supported in the pores and/or on the surface of the porous zeolite.

Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.

Abstract: The present invention relates to a method for preparing a non-acid-treated eco friendly cellulose nanocrystal and the cellulose nanocrystals prepared by the same. The methods for preparing the non-acid-treated cellulose nanocrystal and extracting the cellulose nanocrystal from cellulosic materials of the present invention are eco-friendly methods, compared with the conventional preparation method for cellulose nanocrystal based on acid-hydrolysis; are efficient due to the total energy saving process; are easy to utilize side products; and are characterized by high yield to produce the target cellulose nanocrystal.

Abstract: Disclosed is a catalyst for producing an olefin, the catalyst having an excellent conversion and excellent selectivity, and a method for preparing the catalyst. The catalyst for producing an olefin, according to the present invention, includes: a support including alumina and an auxiliary support component; a main catalyst including an active metal oxide supported on the support; and a co-catalyst including an oxide of an alkali metal and a Group 6B transition metal.