Abstract: A hybridization method of Sinocyclocheilus grahami and carp, which comprises parent fish cultivation, artificial insemination, fish egg incubating and fry feeding, strictly controls environmental parameters and feed types of parent fish cultivation, simulates good living conditions for S. grahami and carp, is beneficial for wild S. grahami and carp to adapt to the artificial breeding environment quickly, realizes natural spermatogenesis and oviposition in artificial environment without using the oxytocin, and provides sperm and eggs both in quality and quantity for artificial hybridization. At the same time, the key parameters during incubation (including incubating water level, water temperature, water flow velocity, pH, dissolved oxygen and sterilization of fertilized eggs, etc.) are also defined to provide suitable environmental conditions for the successful incubation of fertilized eggs.
Type:
Grant
Filed:
March 17, 2021
Date of Patent:
January 10, 2023
Assignee:
KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
Inventors:
Yuanwei Zhang, Xiao'ai Wang, Xiaofu Pan, Junxing Yang
Abstract: Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection.
Type:
Grant
Filed:
March 4, 2019
Date of Patent:
September 20, 2022
Assignees:
Yunnan University, Kunming Institute of Zoology, Chinese Academy of Sciences
Abstract: Disclosed is a DACOs-type NNRTIs amino acid ester derivative, a preparation method thereof, a pharmaceutical composition, and an application thereof. The structure of the DACOs-type NNRTIs amino acid ester derivative is represented by formula (I). The DACOs-type NNRTIs amino acid ester derivative represented by formula (I) can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses.
Type:
Grant
Filed:
March 4, 2019
Date of Patent:
August 23, 2022
Assignees:
Yunnan University, Kunming Institute of Zoology, Chinese Academy of Sciences
Abstract: The present invention relates to a method of treating, mitigating, minimizing, or preventing HIV-1/AIDS by administering a CD24 protein to a subject in need thereof. Also provided herein is use of a CD24 protein in the manufacture of a medicament for treating HIV-1/AIDS. Further, provided is a pharmaceutical composition comprising a pharmaceutically acceptable amount of a CD24 protein.
Type:
Application
Filed:
March 5, 2019
Publication date:
February 18, 2021
Applicants:
ONCOIMMUNE, INC, UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, INSTITUTE OF BIOPHYSICS, CHINESE ACADEMY OF SCIENCES, KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
Inventors:
Yang Liu, Pan Zhang, Lishan Su, Yong-Tang Zheng, Liguo Zhang
Abstract: A use of 3,4,7-trihydroxyisoflavone or 3-methoxydaidzein is provided for implementation in preparation of a drug for inhibiting platelet aggregation. The 3,4,7-trihydroxyisoflavone or 3-methoxydaidzein has a significant inhibition effect on platelet aggregation, and bleeding test conducted with these embodiments show that all of the mice administrated with 3,4,7-trihydroxyisoflavone and 3-methoxydaidzein did not show any significant hemorrhagic activity, while the control group, i.e., the group administrated with the same concentration of clopidogrel showed very significant hemorrhagic activity. Thus, the use of such a drug of the present invention is useful in inhibiting platelet aggregation, and the use of such a drug can reduce the risk of bleeding, is safe for use, and expands the clinical and medical applications thereof.
Type:
Application
Filed:
May 3, 2017
Publication date:
June 20, 2019
Applicant:
Kunming Institute of Zoology, Chinese Academy of Sciences
Inventors:
Ren Lai, Chuanbin Shen, Qiumin Lv, Ming Liu
Abstract: Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.
Type:
Grant
Filed:
October 13, 2011
Date of Patent:
May 3, 2016
Assignees:
Kunming Institute of Botany, The Chinese Academy of Sciences, Yunnan University, Kunming Institute of Zoology, The Chinese Academy of Sciences
Abstract: The present invention relates to the application of 5-methyl-1,3-benzenediol or its derivatives represented by Formula I; wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them in the preparation of medicines or functional foods. The present studies indicate that 5-methyl-1,3-benzenediol or its derivatives represented by Formula I, wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them show more significant antidepressant effects than fluoxetine or imipramine.
Type:
Grant
Filed:
July 25, 2008
Date of Patent:
October 14, 2014
Assignees:
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Jingbiao Biosciences R&D Co., Ltd.
Inventors:
Jijun Chen, Lin Xu, Jun Zhou, Jun Lu, Rongrong Mao, Meng Tian, Qixin Zhou, Xuemei Zhang, Yong Shen, Zhiyong Jiang, Aixue Zuo
Abstract: Nitrogen-containing biphenyl compounds as represented by formula (I), pharmaceutically acceptable salts or derivatives thereof, pharmaceutical compositions, and preparation methods therefore, and anti-HIV-1 use of the compound. Each substituent group in formula (I) is as defined in the description.
Type:
Application
Filed:
October 13, 2011
Publication date:
December 12, 2013
Applicants:
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming Institute of Zoology, The Chinese Academy of Sciences, Yunnan University
Abstract: The present invention relates to the application of 5-methyl-1,3-benzenediol or its derivatives represented by Formula I; wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them in the preparation of medicines or functional foods. The present studies indicate that 5-methyl-1,3-benzenediol or its derivatives represented by Formula I, wherein the constituent variables are as defined herein or pharmaceutical compositions thereof containing them show more significant antidepressant effects than fluoxetine or imipramine.
Type:
Application
Filed:
July 25, 2008
Publication date:
July 29, 2010
Applicants:
KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMY OF SCIENCES, KUNMING INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES, KUNMING JINGBIAO BIOSCIENCES R&D CO., LTD.
Inventors:
Jijun Chen, Lin Xu, Jun Zhou, Jun Lu, Rongrong Mao, Meng Tian, Qixin Zhou, Xuemei Zhang, Yong Shen, Zhiyong Jiang, Aixue Zuo
Abstract: The present invention relates to concentricolide and its derivatives, a method for the preparation of the compound and its derivatives, a pharmaceutical composition containing concentricolide and its derivatives, and use of the compound and its derivatives for the treatment and prevention of infection caused by human immunodeficiency virus (HIV).
Type:
Grant
Filed:
October 20, 2004
Date of Patent:
February 9, 2010
Assignees:
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming Institute of Zoology, The Chinese Academy of Sciences