Patents Assigned to Kyoto University
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Publication number: 20230260646Abstract: The present invention aims to provide a relationship estimation system capable of estimating a relationship of attributes meaningful to a person based on time-series data of attributes relating to a body or activities of a person. The relationship estimation system collects time-series data of attributes relating to a body or activity of a person, calculates similarity between time-series data of the attributes, and generates a relationship graph G in which the attributes are served as nodes, the similarity is served as a link weight, and the nodes are connected by the links. An inter-node having a large total link weight of the inter-node in the relationship graph G is extracted, and the relationship between attribute corresponding to the inter-node is estimated.Type: ApplicationFiled: June 17, 2021Publication date: August 17, 2023Applicants: KYOTO UNIVERSITY, VELDT INC.Inventors: Ryoichi SHINKUMA, Jin NONOGAMI
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Patent number: 11709213Abstract: While the size of a coil is maintained, the performance of the coil is improved. A method for designing a gradient coil includes the step of determining performance value evaluation points between a plurality of coils disposed so as to face each other, and determining a stream function on the basis of the performance value evaluation points and the target field method so as to decrease the value of a polynomial evaluation function containing a term of a simple sum of sizes of current density distribution in coil planes; and the step of disposing a continuous current pathway in the coil planes on the basis of contours of the determined stream function.Type: GrantFiled: November 25, 2020Date of Patent: July 25, 2023Assignees: KYOTO UNIVERSITY, KYOTO FUTURE MEDICAL INSTRUMENTS INC.Inventors: Tomohiro Ueno, Hector Sanchez Lopez
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Publication number: 20230227536Abstract: The present invention relates to a low-molecular antibody composed of D-amino acids and achiral glycine, a method for producing the same, and a method for screening the low-molecular antibody using a mirror-image target protein corresponding to a target protein and an antibody library.Type: ApplicationFiled: June 17, 2021Publication date: July 20, 2023Applicant: Kyoto UniversityInventors: Motohiro NONAKA, Shinya OISHI, Hiroaki OHNO, Keisuke AOKI
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Publication number: 20230214998Abstract: A cell evaluation method evaluates the quality of a cell population including a plurality of cells. The cell evaluation method comprises: an index calculation step of calculating an index, based on a captured image of the cell population, the index including at least any one of an average distance representing a packing degree of the cells, a spring constant representing a degree of consistency in distances between the cells, and a hexagonal order parameter representing a degree to which an arrangement of the cells resembles a regular hexagon; and an evaluation step of evaluating the cell population, based on the index calculated in the index calculation step.Type: ApplicationFiled: July 29, 2022Publication date: July 6, 2023Applicants: Kyoto University, Kyoto Prefectural Public University CorporationInventors: Motomu Tanaka, Akihisa Yamamoto, Morio Ueno, Junji Hamuro, Shigeru Kinoshita, Hiroshi Tanaka, Munetoyo Toda, Chie Sotozono
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Publication number: 20230214722Abstract: A forecast support device acquires learning data including: a forecast value; and an actual value when the forecast value is disclosed. The forecast support device trains a model indicating a relationship between: the forecast value; and the actual value when the forecast value is disclosed, by using the learning data.Type: ApplicationFiled: December 23, 2022Publication date: July 6, 2023Applicants: NEC CORPORATION, KYOTO UNIVERSITYInventors: Akira TANIMOTO, Koh TAKEUCHI
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Patent number: 11692999Abstract: The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A.Type: GrantFiled: June 17, 2021Date of Patent: July 4, 2023Assignee: KYOTO UNIVERSITYInventors: Shigekazu Nagata, Katsumori Segawa
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Patent number: 11685919Abstract: An object of the present invention is to provide a therapeutic agent for hereditary spastic paraplegia (HSP) SPG4. Specifically, the present invention relates to a composition for preventing or treating a neurodegenerative disease such as hereditary spastic paraplegia SPG4, the composition comprising, as an active ingredient, a substance that inhibits a function of miR-33a.Type: GrantFiled: June 21, 2019Date of Patent: June 27, 2023Assignee: Kyoto UniversityInventors: Haruhisa Inoue, Koh Ono, Keiko Imamura, Takahiro Horie, Fumiko Nakazeki
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Patent number: 11680262Abstract: A method of skipping a target exon of a gene of interest in a genome uses CRISPR-Cas and guide RNA. The guide RNA contains a spacer sequence such that the site of cleavage by the CRISPR-Cas is positioned within 80 bases from the splice donor site immediately before the target exon or the splice acceptor site immediately after the target exon.Type: GrantFiled: November 21, 2017Date of Patent: June 20, 2023Assignee: KYOTO UNIVERSITYInventors: Hongmei Li, Noriko Sasakawa, Akitsu Hotta
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Patent number: 11670910Abstract: A method for manufacturing a GaN-based surface-emitting laser by an MOVPE includes: (a) growing a first cladding layer with a {0001} growth plane; (b) growing a guide layer on the first cladding layer; (c) forming holes which are two-dimensionally periodically arranged within the guide layer; (d) etching the guide layer by ICP-RIE using a chlorine-based gas and an argon; (e) supplying a gas containing a nitrogen to cause mass-transport, and then supplying the group-III gas for growth, whereby a first embedding layer closing openings of the holes is formed to form a photonic crystal layer; and (f) growing an active layer and a second cladding layer on the first embedding layer, The step (d) includes a step of referring to already-obtained data on a relationship of an attraction voltage and a ratio of gases in the ICP-RIE with a diameter distribution of air holes embedded, and applying the attraction voltage and the ratio to the ICP-RIE.Type: GrantFiled: December 16, 2020Date of Patent: June 6, 2023Assignees: KYOTO UNIVERSITY, STANLEY ELECTRIC CO., LTD.Inventors: Susumu Noda, Tomoaki Koizumi, Kei Emoto
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Publication number: 20230168251Abstract: New use of ADAMTS13 in the clinical filed is provided. The use of ADAMTS13 as a biomarker for monitoring the onset of liver damage, hepatic ischemia/reperfusion injury or the liver function after liver transplantation: a method of testing liver damage, a method of testing hepatic ischemia/reperfusion injury, or a method of testing the liver function after liver transplantation, each of the methods comprising measuring or monitoring the ADAMTS13 activity in a sample from a mammal; an agent for treating diseases selected from the group consisting of liver damage, hepatic ischemia/reperfusion injury and hepatic dysfunction after liver transplantation, which comprises ADAMTS13 or a mutant of ADAMTS13 as an effective ingredient.Type: ApplicationFiled: December 6, 2022Publication date: June 1, 2023Applicants: KYOTO UNIVERSITY, KM BIOLOGICS CO., LTD.Inventors: Koichiro HATA, Shinji UEMOTO, Hirofumi HIRAO, Toyonari KUBOTA
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Patent number: 11662339Abstract: The present invention provides markers for judging the efficacy of therapy with a PD-1 signal inhibitor before or at an early stage of the therapy. As biomarkers for predicting or judging the efficacy of therapy with a PD-1 signal inhibitor, surrogate indicators of metabolic changes relating to mitochondrial activity in T cells and/or T cell activation in a subject are used. As such indicators, intestinal flora-related metabolites in the serum or plasma, energy metabolism-related metabolites in the serum or plasma, amino acid metabolism-related metabolites and/or derivatives thereof in the serum of plasma, oxygen consumption rate and/or ATP turnover in peripheral blood CD8+ cells, amino acids in T cells, and T-bet in peripheral blood CD8+ cells may be used.Type: GrantFiled: November 1, 2017Date of Patent: May 30, 2023Assignee: Kyoto UniversityInventors: Tasuku Honjo, Kenji Chamoto, Fumihiko Matsuda, Yasushi Okuno, Sidonia Fagarasan
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Publication number: 20230159924Abstract: A prophylactic or therapeutic agent for an aneurysm comprising a miR-33b inhibiting substance, preferably an antisense oligonucleotide against miR-33b, as an active ingredient.Type: ApplicationFiled: March 2, 2021Publication date: May 25, 2023Applicants: MITSUBISHI TANABE PHARMA CORPORATION, KYOTO UNIVERSITY, OSAKA UNIVERSITY, NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITIONInventors: Jun KOTERA, Koh ONO, Takahiro HORIE, Tomohiro YAMASAKI, Satoshi KOYAMA, Satoshi OBIKA, Yuya KASAHARA
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Publication number: 20230159891Abstract: The following are disclosed: a method for producing a T cell progenitor, including step (1) of culturing CD34+ cell in a medium containing an aryl hydrocarbon receptor antagonist, a medium for T cell progenitor differentiation containing an aryl hydrocarbon receptor antagonist, and a T cell progenitor inducer containing an aryl hydrocarbon receptor antagonist.Type: ApplicationFiled: March 30, 2021Publication date: May 25, 2023Applicants: Kyoto University, TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Shin KANEKO, Shoichi IRIGUCHI
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Publication number: 20230159925Abstract: The present invention provides a compound or a pharmaceutically acceptable salt thereof containing a modified oligonucleotide with a length of 8 to 80 consecutive nucleosides, in which the modified oligonucleotide has a nucleobase sequence containing at least 8 consecutive nucleobases contained in a nucleobase sequence of any one of SEQ ID NOs: 3 to 73. With the compound or a pharmaceutically acceptable salt thereof, it is possible to treat a disease or a condition against which inhibition of CALM2 gene expression by controlling of the CALM2 gene expression is effective (particularly, congenital long QT syndrome).Type: ApplicationFiled: March 4, 2021Publication date: May 25, 2023Applicants: NISSAN CHEMICAL CORPORATION, KYOTO UNIVERSITYInventors: Yusuke IRIYAMA, Yoshiki KONDO, Yuuki HIDAKA, Ryutarou ISHIKAWA, Hiroyuki TSUKADA, Takeru MAKIYAMA, Yuta YAMAMOTO
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Patent number: 11655310Abstract: Provided are: a fine cellulose fiber that is superior in handling properties and that can suitably be used as a reinforcing material or the like for resin; a production method of the fine cellulose fiber; and a slurry and a composite comprising the fine cellulose fibers. The present invention pertains to fine cellulose fibers comprising a carbamate group. The degree of substitution with the carbamate group with respect to hydroxy groups in the fine cellulose fibers is preferably no less than 0.05 and no greater than 0.5. The present invention pertains to a slurry comprising the fine cellulose fibers, to a composite comprising the fine cellulose fibers and a resin, and to a production method of the fine cellulose fibers, comprising performing a heat treatment on a mixture of a plant raw material and urea or the like, and performing a miniaturization treatment of the plant raw material.Type: GrantFiled: June 13, 2018Date of Patent: May 23, 2023Assignees: KYOTO UNIVERSITY, DAIO PAPER CORPORATIONInventors: Yoshinobu Tsujii, Keita Sakakibara, Koji Tanaka, Takahito Ikuma, Junya Okawa, Ikko Matsusue
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Publication number: 20230155987Abstract: A blockchain network system includes a plurality of sensor devices and a blockchain network. The sensor devices are communicably connected with each other via the blockchain network, and sensor data acquired by the sensor devices is managed on the blockchain network in a distributed manner The sensor device includes a sensor unit for sequentially acquiring sensor data in real space on a frame-by-frame basis, a data processing unit for processing the sensor data, a data storage unit for storing the sensor data, an encryption unit for encrypting the sensor data, and a registration unit for registering the sensor data encrypted by the encryption unit on the BC network. The data processing unit aggregates the sensor data with a predetermined number of frame aggregations. The encryption unit collectively encrypts the sensor data aggregated by the data processing unit with the predetermined number of frame aggregations.Type: ApplicationFiled: March 8, 2021Publication date: May 18, 2023Applicant: Kyoto UniversityInventor: Ryoichi SHINKUMA
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Patent number: 11648279Abstract: Provided are a composition for cell transplant and a method for cell transplant, both of which enable a myocardial tissue to favorably retain cardiac myocytes and/or cardiac progenitors and can improve the persistence and proliferation of transplanted cells. The composition for cell transplant of the present invention is a composition for cell transplant, containing cells and an aqueous solution containing a protein (A), the cells including a cardiac myocyte and/or a cardiac progenitor, the protein (A) having a degree of hydrophobicity of 0.2 to 1.Type: GrantFiled: May 9, 2019Date of Patent: May 16, 2023Assignees: KYOTO UNIVERSITY, SANYO CHEMICAL INDUSTRIES, LTD.Inventors: Yoshinori Yoshida, Takeshi Hatani, Ryosuke Suzuki, Shingo Kawabata
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Publication number: 20230138638Abstract: In a method for producing hydrogen and carboxylic acid, a primary alcohol of 1 to 7 carbon atoms and water are reacted by being continuously introduced into a flow reactor packed with a solid catalyst consisting of an alloy of ruthenium and tin on a support and passed through the reactor under temperature and pressure conditions at which the water assumes a gaseous state. This method enables hydrogen and carboxylic acid to be produced in a high yield or at a high purity from a primary alcohol and water in a short time and by simple operations.Type: ApplicationFiled: October 14, 2022Publication date: May 4, 2023Applicants: Kyoto University, Shin-Etsu Chemical Co., Ltd.Inventors: Haruo KAWAMOTO, Eiji MINAMI, Yuanyuan ZHAO, Takashi NOMURA, Kazuto KOBAYASHI, Akiko MIKI
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Publication number: 20230135926Abstract: A superconducting rotating machine includes a stator that includes a cylindrical stator iron core and a stator winding that is toroidally wound around the stator iron core and formed of a superconducting material, and generates a rotating magnetic field, an inner rotor rotatably held at an inner circumferential side of the stator, and an outer rotor rotatably held at an outer circumferential side of the stator. The inner and outer rotors each include at least one rotor winding selected from a superconducting squirrel cage winding including a single or a plurality of rotor bars and end rings that are formed of a superconducting material, and a normal conducting squirrel cage winding including a single or a plurality of rotor bars and end rings that are formed of a normal conducting material, and a rotor iron core including a plurality of slots that accommodate respective rotor bars of the rotor winding.Type: ApplicationFiled: March 24, 2021Publication date: May 4, 2023Applicant: KYOTO UNIVERSITYInventor: Taketsune NAKAMURA
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Patent number: 11639880Abstract: According to one embodiment, a structure evaluation system according to an embodiment includes a plurality of sensors, a position locator, and an evaluator. The plurality of sensors detect elastic waves. The position locator locates positions of elastic wave sources by using the elastic waves among the plurality of elastic waves respectively detected by the plurality of sensors having an amplitude exceeding a threshold value determined according to positions of the sources of the plurality of elastic waves and the positions of the plurality of disposed sensors. The evaluator evaluates a deteriorated state of the structure on the basis of results of the position locating of the elastic wave sources which is performed by the position locator.Type: GrantFiled: October 13, 2021Date of Patent: May 2, 2023Assignees: Kabushiki Kaisha Toshiba, Kyoto UniversityInventors: Tomoki Shiotani, Katsufumi Hashimoto, Hidefumi Takamine, Kazuo Watabe