Abstract: The present invention relates to the use of modafinil for the manufacture of a medicinal product for the treatment of urinary and fecal incontinence and urethrovesical and anal sphincteral disorders.

Abstract: The invention relates to a method for protecting the cerebral tissue of a human against the repercussions of ischaemia which comprises administering to a patient in need thereof a therapeutically effective amount of modafinil.

Abstract: The invention relates to compounds having the formula: ##STR1## in which Ar represents a group selected from 2-nitrophenyl, 3-nitrophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, 2-trifluoromethylphenyl and 3-trifluoromethylphenyl;R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a group having the formula: ##STR2## A represents a group selected from groups having the formulae: ##STR3## and R.sub.2 represents a group selected from 2,4,6-trimethoxyphenyl, 2-thienyl and phenyl, and their addition salts with pharmaceutically acceptable acids.These compounds are calcium inhibitors with therapeutic applications.

Abstract: The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperazino, 4-phenyl-piperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof.These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.

Abstract: The present invention relates to a method for providing a patient with neuroprotective effect, which consists in administering modafinil to said patient.

Abstract: The present invention relates to 1-(4-aminophenyl)-2-piperidinopropanone derivatives which are selected from(a) the compounds corresponding to the general formula ##STR1## where R is H or CH.sub.3 CO, A is H or Cl, B is H or Cl and Z is C.sub.1 -C.sub.4 -alkyl; and(b) their addition salts,These products are used as cardiovascular agents. In particular, the compounds of the formula I where R=H or CH.sub.3 CO, A=B=Cl and Z=CH.sub.3, and their addition salts, are especially very worthwhile as vasodilators.

Abstract: The subject of the invention is peptide derivatives corresponding to formulaX.sup.1 - X.sup.2 - Gly - Asp-X.sup.3 - X.sup.4 (I)in which:X.sup.1 represents a hydrogen atom, a N-protecting group, an amino acid residue or a N-protected amino acid residue,X.sup.2 represents a residue of L-Arg or D-Arg, L-Orn or D-Orn, N-aminocarbonyl -L-Orn or N-aminocarbonyl-D-Orn, or L-Lys, or D-Lys,X.sup.3 represents a residue of L-Trp, D-Trp, L-Leu, D-Leu, L-Ile, D-Ile, L-Phe, D-Phe or a chain of 2 or 3 of these residues, andX.sup.4 represents a -OH group, -NH.sub.2 group, -OR.sup.1 group in which R.sup.1 represents an alkyl radical of C.sub.1 to C.sub.4, a NHR.sup.2 group in which R.sup.2 represents an alkyl radical of C.sub.1 to C.sub.4, or an amino acid residue.These derivatives are useful in therapy on account of their platelet aggregation inhibiting activity.

Abstract: The present invention relates to 1-(4-aminophenyl-2)-hexamethyleniminopropanone and its pharmaceutically acceptable addition salts.These products are useful in therapy on account of their antidepressant effects on the CNS and their immunological properties.

Abstract: The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperzaino, 4-phenylpiperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof.These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.

Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichNR.sub.1 R.sub.2 represents a piperidino group; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.sub.3 CONH and Y and Z, which can be identical or different, each represent a hydrogen or halogen atom; and(b) their addition salts.These new products are useful as antidepressants for the central nervous system. The invention also relates to the method for their preparation.

Abstract: The present invention relates, by way of novel industrial products, to 1-(4-aminophenyl)-2-dimethylaminopropanone derivatives which are selected from:(a) the compounds having the general formula ##STR1## in which R is H or CH.sub.3 CO, and (b) addition salts thereof.These products are useful as antidepressants. Furthermore, 1-(4-acetylamino-3,5-dichlorophenyl)-2-dimethylaminopropanone and non-toxic addition salts thereof are useful as immunostimulants.

Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichR.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.6 cycloalkyl group;R.sub.2 represents the hydrogen atom or a C.sub.1 -C.sub.4 alkyl group;R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, an N-heterocyclic group with 5 to 7 ring members, capable (i) of including a second heteroatom selected from N, O and S, and (ii) of being substituted, the said heterocyclic group NR.sub.1 R.sub.2 being selected from the group comprising pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino, 4-(.beta.-hydroxyethyl) piperazino, 4-phenylpiperazino and 4-(p-chlorophenyl)-piperazino groups; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.

Abstract: The levorotatory isomer of benzhydrylsulfinylacetamide has useful pharmaceutical activity on the central nervous system, particularly as an antidepressant and stimulant in the treatment of hypersomnia and Alzheimer's disease.

Abstract: The present invention relates, by way of a novel industrial product, to a filter for gaseous fluid, which contains a lyophilized and compressed filter element in the form of a porous layer.

Abstract: The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of(a) the compounds of the formulaAr--CO--CH(CH.sub.3)--NR.sub.1 R.sub.2 (I)in whichR.sub.1 represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.3 -C.sub.6 cycloalkyl group;R.sub.2 represents the hydrogen atom or a C.sub.1 -C.sub.4 alkyl group;R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, an N-heterocyclic group with 5 to 7 ring members, capable (i) of including a second heteroatom selected from N, O and S, and (ii) of being substituted, the said heterocyclic group NR.sub.1 R.sub.2 being selected from the group comprising pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino, 4-(.beta.-hydroxyethyl) piperazino, 4-phenylpiperazino and 4-(p-chlorophenyl)-piperazino groups; andAr represents an acetylaminophenyl group of the formula ##STR1## in which X is CH.

Abstract: The present invention relates to a process for the treatment of depression comprising administering to a human in need thereof an antidepressant amount of a compound selected from 1-(2-fluorophenyl)-2-tertiobutylamino-1-ethanol and an addition salt thereof.

Abstract: The present invention relates to 4-phenylthiazole derivatives, namely 2-(2-hydroxyethylamino)-4-phenylthiazole and its addition salts.These derivatives act on the CNS and are useful as sedatives.

Abstract: The present invention relates to new compounds belonging to the family of fluorophenacyl-amine derivates of formula: ##STR1## [wherein A is CO or CHOH and R is CH(CH.sub.3).sub.2 or C(CH.sub.3).sub.3 ] and selected from the group consisting of N-(4-fluorophenacyl)-isopropylamine, N-(2-fluorophenacyl)-tertiarybutylamine, 1-(2-fluorophenyl)-2-tertiarybutylamino-1-ethanol, 1-(4-fluorophenyl)-2-tertiarybutylamino-1-ethanol, and their addition salts, These new derivatives are useful in therapeutics, particularly as anti-aggressive agents, anti-anorexia nervosa agents, sedative agents, and CNS- antidepressants.

Abstract: The present invention relates to the preparation of new derivatives selected from the group consisting of:(i) 1-(aminophenyl)-2-(alkylamino)ethanones of the formula: ##STR1## in which R is CH(CH.sub.3).sub.2 or C(CH.sub.3).sub.3 ; and (ii) addition salts thereof.These new derivatives are useful in therapy, in particular as antidepressants or stimulants for the CNS. They are prepared from 1-(acetylaminophenyl)-2-(alkylamino)ethanone derivatives by deacetylation.

Abstract: The present invention relates to new derivatives selected from the group comprising:(i) the 5-phenylhydropyrimidines of the formula: ##STR1## in which: X.sub.1 and X.sub.2, which are identical or different, each represent H, F, Cl, Br or CF.sub.3, andA represents a polyhydropyrimidinyl group of the structure: ##STR2## in which: Y represents H or OH,R.sub.a represents a C.sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.5 alkanoyl group, it being possible for R.sub.a to represent the hydrogen atom when at least one of the groups X.sub.1, X.sub.2 and Y is different from H,R.sub.b represents a C.sub.1 -C.sub.3 alkyl group, andR.sub.c.sup.1 and R.sub.c.sup.2, which are identical or different, each represent the hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; and(ii) their addition salts.The said derivatives are useful as pharmaceuticals.