Patents Assigned to Laboratories del Dr. Esteve S.A.
  • Patent number: 9988425
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including the immunogens.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: June 5, 2018
    Assignees: Laboratories Del Dr. Esteve S.A., Fundació Privada Institut De Recerca De La Sida—CAIXA
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • Patent number: 9782483
    Abstract: The invention refers to the use of a sigma ligand, preferably a sigma ligand of formula (I), to prevent or treat emesis induced by a chemotherapeutic agent or radioactivity, especially emesis induced by taxanes, vinca alkaloids or platin chemotherapeutic drugs.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: October 10, 2017
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: José Miguel Vela Hernández, Xavier Codony-Soler, Daniel Zamanillo-Castanedo
  • Patent number: 9617281
    Abstract: The present invention relates to new imidazo[2,1-b]thiazole derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: April 11, 2017
    Assignee: LABORATORIES DEL DR. ESTEVE S.A.
    Inventors: María de las Ermitas Alcalde-Pais, José Luís Diaz Fernández, María de les Neus Mesquida-Estevez, Laura Paloma-Romeu
  • Patent number: 9393220
    Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: July 19, 2016
    Assignee: LABORATORIES DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Lluis Sola Carandell, Jordi Benet Buchholz, Jordi Carles Ceron Bertran, Carlos Ramon Plata Salaman, Nicolas Tesson
  • Patent number: 9241927
    Abstract: The present invention relates to a pharmaceutical composition that comprises a compound of formula (I) as active pharmaceutical ingredient: or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof; and at least a pharmaceutically acceptable excipient, wherein the active pharmaceutical ingredient is present in an amount of at least 80% of the total dry weight of the composition.
    Type: Grant
    Filed: November 25, 2010
    Date of Patent: January 26, 2016
    Assignee: Laboratories Del Dr, Esteve, S.A.
    Inventors: Luis Soler Ranzani, Pierandrea Esposito, Gemma Casadevall Pujals, Nuria Cubel Suñé
  • Patent number: 9051275
    Abstract: The present invention relates to polymorphs and solvates of the hydrochloride salt of 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine (P027), processes for their preparation, and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: June 9, 2015
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Ramón Berenguer Maimó, Jorge Medrano Rupérez, Jordi Benet Buchholz, Laura Puig Fernandez, Laia Pellejà Puxeu
  • Publication number: 20150031678
    Abstract: The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: February 21, 2013
    Publication date: January 29, 2015
    Applicant: LABORATORIES DEL DR. ESTEVE S.A.
    Inventors: José Luis Diaz Fernández, Ma Rosa Cuberes Altisent
  • Patent number: 8492425
    Abstract: The invention relates to compounds having the formula (I): wherein the dashed line (represented by - - - ) represents an optional double bond; R1 is hydrogen and R2 is hydroxyethyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl ring optionally substituted with one or two hydroxy groups; each R3 is independently hydroxy or C1-6alkoxy; n is selected from 0, 1, and 2; or a N-oxide, salt, prodrug, solvate or stereoisomer thereof; with the proviso that the compound where the dashed line represents a double bond, R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl ring, and n is 0, is excluded. Also provided are methods for the preparation of compounds of formula (I); their uses as a medicaments, particularly for the treatment or prophylaxis of a sigma receptor mediated diseases or conditions.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: July 23, 2013
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Maria Rosa Cuberes-Altisent, Maria Jose Pretel Sanchez, Maria Magdalena Bordas Gelabert
  • Patent number: 8410159
    Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 2, 2013
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Rosa Cuberes-Altisent, Joerg Holenz
  • Patent number: 8362011
    Abstract: The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: January 29, 2013
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrens-Jover, Félix Cuevas-Cordobes, Susana Yenes-Minguez
  • Patent number: 8293740
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 23, 2012
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Christian Laggner, Maria Rosa Cuberes-Altisent, Joerg Holenz, Juana Maria Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • Patent number: 8044053
    Abstract: The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: October 25, 2011
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Helmut Buschmann, Antonio Torrens-Jover, Josef Mas-Prio, Susana Yenes-Minguez
  • Publication number: 20110105443
    Abstract: The present invention relates to salts of Memantine and COX-INHIBITORs, their crystal form, the processes for preparation of the same and their uses for the treatment of various disorders, including pain.
    Type: Application
    Filed: March 6, 2009
    Publication date: May 5, 2011
    Applicant: LABORATORIES DEL DR. ESTEVE, S.A.
    Inventors: Helmut Heinrich Buschmann, Nicolas Tesson, Joan Farran, Llorenc Rafecas
  • Patent number: 7553965
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: June 30, 2009
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Susana Yenes Mínguez, Josep Mas Prió, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Henrich Buschmann
  • Publication number: 20090030013
    Abstract: The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 29, 2009
    Applicant: LABORATORIES DEL DR. ESTEVE, S.A.
    Inventors: Jose Luis Diaz-Fernandez, Ramon Merce-Vidal, Lajos Novak
  • Patent number: 7452881
    Abstract: The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: November 18, 2008
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Ramón Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa
  • Publication number: 20080280942
    Abstract: The present invention relates to new tetrahydro-?-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.
    Type: Application
    Filed: July 26, 2006
    Publication date: November 13, 2008
    Applicant: LABORATORIES DEL DR. ESTEVE, S.A.
    Inventors: Jose Luis Diaz-Fernandez, Ramon Merce-Vidal, Joerg Holenz
  • Patent number: 7291728
    Abstract: The present invention is directed to a compound of formula I: wherein R1 and R2 are independently selected from H, halogen, protected or unprotected hydroxy, alkylsilyloxy, substituted or unsubstituted alkyl or cycloalkyl, substituted or unsubstituted alkoxy or aryloxy, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, nitro, amino, mercapto or alkylthio; R3 and R4 are independently selected from H, substituted alkyl, substituted or unsubstituted alkoxy or aryloxy, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl; Z is —(CRaRb)n— wherein n is a number selected from 1, 2, 3 and Ra and Rb are each independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy, substituted or unsubstituted amino or halogen; Y is
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: November 6, 2007
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Pedro Noheda Marin, Manuel Bernabe Pajares, Sergio Maroto Quintana, Nuria Tabares Cantero
  • Patent number: 7176200
    Abstract: The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: February 13, 2007
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Ramón Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa
  • Patent number: 7105515
    Abstract: The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 12, 2006
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Ramón Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa