Patents Assigned to Leica Biosystems Melbourne Pty Ltd
  • Publication number: 20210080359
    Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 18, 2021
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Peter TOOGOOD, Kenneth HENG-CHONG NG, Anthony FAVALORO, Stephen John BAGNATO, Gregory William BOYES
  • Patent number: 10876936
    Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: December 29, 2020
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Peter Toogood, Kenneth Heng-Chong Ng, Anthony Favaloro, Stephen John Bagnato, Gregory William Boyes
  • Publication number: 20200355581
    Abstract: The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.
    Type: Application
    Filed: December 19, 2018
    Publication date: November 12, 2020
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Zbigniew MIODUSZEWSKI, Aaron RIDGWAY, Matthew KING, Blake HELLARD
  • Publication number: 20200319067
    Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
    Type: Application
    Filed: June 24, 2020
    Publication date: October 8, 2020
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: Kenneth HE-CHO NG
  • Patent number: 10718695
    Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: July 21, 2020
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
  • Publication number: 20200188904
    Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
    Type: Application
    Filed: January 3, 2020
    Publication date: June 18, 2020
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
  • Publication number: 20200188924
    Abstract: A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.
    Type: Application
    Filed: August 17, 2018
    Publication date: June 18, 2020
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Campbell RICHARDS, Matthew Struan KING, Cyril LIM
  • Publication number: 20200174029
    Abstract: A method of operating a tissue processor for processing tissue samples. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and thereby automatically determining whether the reagent is suitable for processing tissue samples in the tissue processor. Also, a tissue processor for processing tissue samples and a container for storing tissue samples.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 4, 2020
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Gordon SEARS, Michael Houston DRUMMOND, Donnchadh OH-AINLE
  • Patent number: 10579029
    Abstract: A server computer system connected to a first communications network. The server computer includes an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system. The UI instances control respective virtual pods representing one or more of said biological reagent instruments.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: March 3, 2020
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: James Maddern
  • Patent number: 10453564
    Abstract: A sample, embedded in a paraffin block, is placed on a tissue cassette which carries a label which may be a bar code. When the sample is processed, the cassette is given to a microtome operator who scans the label. Scanning causes information to be displayed on a screen and the operator verifies that what is on the screen matches what was on the label. The paraffin block is then placed in a microtome chuck and sections are cut from the block. A number of slide labels related to the cassette label are printed for the sections. If the operator does not verify that the information displayed on the screen matches the information on the cassette label and/or does not place the paraffin block in the microtome chuck within an allocated time interval after scanning the cassette label, dispensing and labeling of slides and/or operation of the microtome is prevented.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: October 22, 2019
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: Phillip Clyde Roberts Gurney
  • Publication number: 20190078986
    Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
    Type: Application
    Filed: October 30, 2018
    Publication date: March 14, 2019
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Kenneth Heng-Chong NG, Mark Brian DOCKRILL, Peter TOOGOOD, Martin LIMON, Daniel DOBROGORSKY, Mark WILCOCK, Greg BOYES, Brendyn RODGERS, Stephen John BAGNATO, Ashan Chiranga PERERA
  • Patent number: 10228382
    Abstract: A fluid transport system for an automated slide treatment apparatus having slide treatment modules is disclosed. The fluid transport system including a fluid dispensing robot configured by a controller to dispense a plurality of reagents to slides received in the slide treatment modules. The fluid dispensing robot includes pumping means configured by the controller to pump the reagents to be dispensed from a plurality of corresponding reagent containers; a probe having a body arranged to store one or more of the reagents pumped via the pumping means so as to prime the probe with said one or more of the reagents to be dispensed; and a well disposed on the body of the probe to store further of the reagents primed to be dispensed.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: March 12, 2019
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian Dockrill, Martin Limon, Michael Houston Drummond, Mark Wilcock, Brendyn Rodgers
  • Patent number: 10145767
    Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: December 4, 2018
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Kenneth Heng-chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
  • Publication number: 20180341238
    Abstract: A server computer system connected to a first communications network. The server computer includes an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system. The UI instances control respective virtual pods representing one or more of said biological reagent instruments.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 29, 2018
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: James MADDERN
  • Publication number: 20180341237
    Abstract: A server computer system connected to a first communications network. The server computer includes an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system. The UI instances control respective virtual pods representing one or more of said biological reagent instruments.
    Type: Application
    Filed: August 3, 2018
    Publication date: November 29, 2018
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: James MADDERN
  • Publication number: 20180321118
    Abstract: Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 8, 2018
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian DOCKRILL, Samuel GASON
  • Publication number: 20180290306
    Abstract: A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Stuart ELLIOT, Andrew MCLELLAN, Chester HENDERSON, Mark DOCKRILL, Simon HARRIS, Peter RIDDELL
  • Patent number: 10054913
    Abstract: A server computer system connected to a first communications network and including: an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network; and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system; wherein said UI instances control respective virtual pods representing one or more of said biological reagent instruments.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 21, 2018
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventor: James Maddern
  • Patent number: 10036690
    Abstract: Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: July 31, 2018
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Mark Brian Dockrill, Samuel Gason
  • Patent number: D908915
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 26, 2021
    Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTD
    Inventors: Stephen John Bagnato, Orlando Skeete, Frank Austin, Eric Nicolas Baessler, Simon Peter Harris