Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.
Type:
Application
Filed:
July 30, 2021
Publication date:
November 18, 2021
Applicant:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Adam Michael GRAY, Michael Stephen GLYNN
Abstract: An apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.
Type:
Grant
Filed:
August 30, 2013
Date of Patent:
August 24, 2021
Assignee:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Adam Michael Gray, Michael Stephen Glynn
Abstract: Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
Abstract: A system for monitoring tissue samples to be processed by a tissue processor for a histopathology workflow, the system including: a scanner associated with the tissue processor arranged to scan an electronic sample identifier of at least one tissue sample to be processed by the tissue processor; an input module arranged to receive tissue processor workflow data indicative of a tissue processor workflow for the at least one tissue sample to be processed by selected ones of a plurality of processing stations in the tissue processor used for processing the at least one tissue sample; a monitoring module arranged to monitor properties of the at least one tissue sample processed at each of the selected ones of the processing stations and to record the properties of the at least one tissue sample in association with the electronic sample identifier in a sample record for the tissue processor workflow; and an output module arranged to output the sample record to one or more laboratory instruments for further process
Abstract: The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.
Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
Type:
Application
Filed:
November 10, 2020
Publication date:
March 18, 2021
Applicant:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Peter TOOGOOD, Kenneth HENG-CHONG NG, Anthony FAVALORO, Stephen John BAGNATO, Gregory William BOYES
Abstract: A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
Type:
Grant
Filed:
December 3, 2013
Date of Patent:
December 29, 2020
Assignee:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Peter Toogood, Kenneth Heng-Chong Ng, Anthony Favaloro, Stephen John Bagnato, Gregory William Boyes
Abstract: The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.
Type:
Application
Filed:
December 19, 2018
Publication date:
November 12, 2020
Applicant:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Zbigniew MIODUSZEWSKI, Aaron RIDGWAY, Matthew KING, Blake HELLARD
Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
Type:
Grant
Filed:
October 30, 2018
Date of Patent:
July 21, 2020
Assignee:
LEICA BIOSYSTEMS MELBOURNE PTY LTD
Inventors:
Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera