Patents Assigned to Leica Biosystems Nussloch GmbH
  • Patent number: 11351555
    Abstract: A holder (40) for holding a stack (10) of coverslips (11) or specimen slides (11) has a bottom (20) having at least one side wall (21a, 21b, 22a, 22b) connected thereto, wherein an inner side of the bottom (20) is embodied for placement of the stack (10) of coverslips (11) or specimen slides (11) and carrying that stack (10), and an outer side of the bottom (20) and/or an outer side of the at least one side wall is configured to receive an identification label, such as an RFID (30), and the holder includes such the identification label, such as an RFID (30).
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: June 7, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: 11333582
    Abstract: The disclosure relates to a microtome having a cutting knife, an object holder mounted on a slide, the slide being movable relative to the cutting knife in a cutting direction and in a thickness defining direction, movement of the slide in the thickness defining direction being performed by a first electric motor controlled by a control unit, movement of the slide in the cutting direction being performed by a second electric motor controlled by the control unit, wherein the control unit is configured to control the movement of the slide in the thickness defining direction and in the cutting direction.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 17, 2022
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventors: Zheguang Fan, Xiaoqi Jiang, Yunchao Yang, Song Jin, Xiang Liang, Jinyu Xu
  • Patent number: 11280709
    Abstract: A coverslipping machine (1) is embodied to be connected to an electrical power grid in order to be supplied with electrical energy as an electrical load; and removes specimen slides (4), having samples present thereon, from a specimen slide magazine (5) and respectively carries out a coverslipping process in which a mounting medium (7) and then a coverslip (8) are applied onto each specimen slide (4); and deposits the coverslipped specimen slides (4) in the specimen slide magazine (5) or in a further specimen slide magazine (55). The coverslipping machine (1) has an electrical energy reservoir (12) and an electronic control apparatus (13).
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 22, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Benjamin Siehl, Markus Sharpe, Markus Wittmann
  • Patent number: 11241220
    Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: February 8, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Jo Fleming, Charles E. Clemens, David Berardelli
  • Patent number: 10481054
    Abstract: The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: November 19, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Florian Böhl, Ralf Eckert, Karin Flieger, Markus Berberich, Hermann Ulbrich, Stella Knorr, Andrew Guy
  • Patent number: 10345202
    Abstract: A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde. The tissue sample (1) is left in the fixing reagent (2) for a fixing time period during which the fixing reagent (2) is brought to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level. A concentration in the fixing reagent (2) of the nitrogen-containing compound is ascertained using at least one concentration measuring device (14) of the tissue processor (10), and a signal is outputted on the basis of a measured value of the at least one concentration measuring device (14).
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 9, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Hermann Ulbrich, Markus Berberich
  • Patent number: 10345198
    Abstract: A method of producing thin sections using a microtome is disclosed. A hand wheel (32) is manually driven for producing a first thin section, and wherein the rotational movement of the hand wheel (32) is detected by an encoder (38), and a profile of the rotational movement is determined. The determined profile is stored and selected for production of at least a second thin section. A motor (24) is driven for generating a cutting movement between a cutting unit (16) and a sample holder (12) in accordance with the respective stored profile selected for producing the second thin section. A microtome (10) to carry out this method is also disclosed.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: July 9, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Roland Walter, Markus Berberich, Markus Wittman
  • Patent number: 10345203
    Abstract: An apparatus for holding a tissue sample including a retaining member having a first tissue engaging surface and at least one biasing element, the first tissue engaging surface being moveably attached to the retaining member by said biasing element; and a base having a second tissue engaging surface and configured to engage the retaining member to form an interior area with the first and second tissue engaging surfaces facing each other, wherein the at least one biasing element urges the first tissue engaging surface toward the second tissue engaging surface to retain the tissue sample therebetween in the interior area.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: July 9, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Stella Knorr, Andrew Guy, Ralf Eckert, Fiona Tarbet, Fernando Dias, Chris Ryan, Neil Sanut
  • Publication number: 20190099167
    Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.
    Type: Application
    Filed: December 3, 2018
    Publication date: April 4, 2019
    Applicant: Leica Biosystems Nussloch GmbH
    Inventors: Jo FLEMING, Charles E. CLEMENS, David BERARDELLI
  • Patent number: 10201331
    Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: February 12, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Jo Fleming, Charles E. Clemens, David Berardelli
  • Patent number: 10151673
    Abstract: A treatment device (1) for treating histological or cytological samples has a plurality of containers (6) for different treatment agents and a detection apparatus (2) for detecting a code which unequivocally identifies a type of a treatment agent or a type of a group of treatment agents from a package or replacement container of a treatment agent or group of treatment agents. The device furthermore has an evaluation apparatus (18) that, based on a detected code, ascertains which of the containers is or are to be replenished or replaced, and an indicating apparatus (4) which communicates to a user the ascertained container (6) or containers (6) that is or are to be replenished or replaced. The indicating apparatus may include a display (5) presenting a schematic image of the plurality of containers (6) with image(s) of each ascertained container being marked, and/or a light source (15) that illuminates each ascertained container.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: December 11, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Bernhard Neef, Markus Wittmann
  • Publication number: 20180345282
    Abstract: A tissue sample container including a base having a plurality of sample holding sections, which are configured to receive a plurality of tissue samples in a given orientation and are demarcated by section walls; and a lid configured to sealingly engage the base. The sample holding sections are sized and shaped to correspond to a specific tissue sample size and shape such that the base in cooperation with the section walls, maintain the given orientation and identity of the tissue samples within respective sample holding sections.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Applicant: Leica Biosystems Nussloch GmbH
    Inventors: Jo FLEMING, Charles E. CLEMENS, David BERARDELLI
  • Patent number: 10092905
    Abstract: A tissue sample container including a base having a plurality of sample holding sections, which are configured to receive a plurality of tissue samples in a given orientation and are demarcated by section walls; and a lid configured to sealingly engage the base. The sample holding sections are sized and shaped to correspond to a specific tissue sample size and shape such that the base in cooperation with the section walls, maintain the given orientation and identity of the tissue samples within respective sample holding sections.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 9, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Jo Fleming, Charles E. Clemens, David Berardelli
  • Patent number: 10060839
    Abstract: An automated embedding machine includes at least a conveyor, a pouring station, and a cooling station. The conveyor is embodied and arranged to receive casting molds each having at least one histological sample arranged therein, and to transport them to the pouring station which fills each casting mold with an embedding medium heated to above its melting point, and then to the cooling station which cools the embedding medium of each casting mold to below its melting point. The disclosure furthermore relates to a method for embedding a histological sample.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: August 28, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Markus Berberich
  • Patent number: 10054364
    Abstract: The invention relates to a melting apparatus (100) for melting paraffin (1), having: a melting container (110) for receiving paraffin (1) to be melted; a storage container (190) for storing molten paraffin (4); having a melting container heating device (120) for heating the melting container (110), having a storage container heating device (191) for heating the storage container (190), having a fluid connection (113) fluidically connecting the melting container (110) and the storage container; the melting container (110), the storage container (190), and the fluid connection (113) being arranged so that molten paraffin (4) flows out of the melting container (110) into the storage container (190).
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 21, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Markus Berberich, Hermann Ulbrich, Florian Böhl, Ralf Eckert, Karin Flieger
  • Patent number: 9918405
    Abstract: A sample cooling device for histological samples is connectable to a power network for supplying electrical voltage to the device. The sample cooling device comprises a measuring apparatus for measuring a magnitude of an input line voltage present at the sample cooling device, and a transformer having a primary coil that comprises at least three coil pickoffs, and a secondary coil. The sample cooling device further comprises a switching means that connects two of the coil pickoffs to the power network as a function of the magnitude of the input line voltage, so that a magnitude of an output voltage present at the secondary coil has a predefined or predefinable voltage value irrespective of the magnitude of the input voltage. A corresponding method for supplying electrical power to a sample cooling device for histological samples is also disclosed.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: March 13, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Markus Berberich, Michael Eberhard
  • Patent number: D810316
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: February 13, 2018
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventor: Werner Hoelbl
  • Patent number: D847366
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: April 30, 2019
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Werner Hoelbl
  • Patent number: D932047
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: September 28, 2021
    Assignee: LEICA BIOSYSTEMS NUSSLOCH GMBH
    Inventor: Werner Hölbl
  • Patent number: D945010
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: March 1, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump