Patents Assigned to Lister Institute of Preventive Medicine
  • Live vaccines
    Patent number: 5851519
    Abstract: The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: December 22, 1998
    Assignees: Glaxo Wellcome Inc., The Royal Society, The Lister Institute of Preventive Medicine, The University Court of The University of Dundee
    Inventors: Gordan Dougan, Steven Neville Chatfield, Christopher Francis Higgins, Charles James Dorman
  • Vaccines comprising attenuated salmonella having mutations in the ompr genes
    Patent number: 5527529
    Abstract: The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: June 18, 1996
    Assignees: The Wellcome Foundation Limited, The Royal Society, The Lister Institute of Preventive Medicine, The University Court of The University of Dundee
    Inventors: Gordan Dougan, Steven N. Chatfield, Christopher F. Higgins, Charles J. Dorman
  • Method of characterizing genomic DNA by reference to a genetic variable
    Patent number: 5413908
    Abstract: It has been a problem that the identification of genomic DNA by restriction fragment length polymorphisms is limited, owing to the low level of genetic variation ordinarily detectable by cloned DNA in this method. The invention provides for improved identification by making use of the existence of DNA regions of hypervariability, otherwise called minisatellite regions in which the DNA contains tandem repeats or quasi-block copolymer sequences and the number of repeats or copolymer units varies considerably from one individual to another. It has now been found that many such regions can be probed simultaneously in such a way as to display this variability using a DNA or other polynucleotide probe of which the essential constituent is a short core sequence tandemly repeated at least 3 and preferably at least 10 times.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: May 9, 1995
    Assignee: Lister Institute of Preventive Medicine
    Inventor: Alec J. Jeffreys