Patents Assigned to Lixte Biotechnology, Inc.
  • HDAC inhibitors
    Patent number: 8143445
    Abstract: This invention provides the compound having the structure wherein n is 1-10; X is C—R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO—R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl; Z is R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl; R5 is OH or SH; and R6, R12, R13, and R14 are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO—R15 wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: March 27, 2012
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Francis Johnson
  • Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
    Patent number: 8058268
    Abstract: Disclosed herein are methods of treating neurodegenerative diseases comprising administering to the subject a compound having the structure: wherein ? and R1-R8 are described herein, or a compound having the structure: wherein Y, Z, and R21, R24, R25, and R31-R33 are described herein.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: November 15, 2011
    Assignee: Lixte Biotechnology, Inc.
    Inventor: John S. Kovach
  • Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use
    Patent number: 7998957
    Abstract: This invention provides compounds having the structure which may be used for the treatment of tumors.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: August 16, 2011
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Francis Johnson