Patents Assigned to LJL BioSystems, Inc.
  • Patent number: 6902703
    Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: June 7, 2005
    Assignee: LJL Biosystems, Inc.
    Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Lev J. Leytes, Samuel Burd
  • Patent number: 6838051
    Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: January 4, 2005
    Assignee: LJL BioSystems, Inc.
    Inventors: Samuel A. Marquiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Ley J. Leytes, Samuel Burd
  • Patent number: 6806053
    Abstract: Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: October 19, 2004
    Assignee: LJL BioSystems, Inc.
    Inventors: J. Richard Sportsman, Lawrence M. Kauvar
  • Publication number: 20040203000
    Abstract: Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides.
    Type: Application
    Filed: January 23, 2001
    Publication date: October 14, 2004
    Applicant: LJL BioSystems, Inc.
    Inventors: J. Richard Sportsman, Lawrence M. Kauvar
  • Publication number: 20030205681
    Abstract: Devices and methods are disclosed comprising providing a sample holder having a plurality of sample wells. Inner and outer surfaces of at least one well are configured for total internal reflection of incident light.
    Type: Application
    Filed: January 12, 2001
    Publication date: November 6, 2003
    Applicant: LJL BioSystems, Inc.
    Inventor: Douglas N. Modlin
  • Patent number: 6576476
    Abstract: A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: June 10, 2003
    Assignee: LJL BioSystems, Inc.
    Inventors: Michael T. Taylor, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin
  • Patent number: 6503719
    Abstract: Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) contacting a sample polynucleotide with a reference polynucleotide at an assay site, where at least one of the polynucleotides is capable of emitting luminescence, (2) illuminating the assay site with light capable of stimulating such luminescence, (3) detecting light transmitted from the assay site, and (4) deriving information relating to the extent of hybridization between the sample and reference polynucleotides based on the detected light. The methods may further include (1) illuminating with and/or detecting polarized light, (2) deriving information relating to the sequence of the sample polynucleotide from the extent of hybridization, and (3) converting the light to a signal and distinguishing between a portion of the signal attributable to luminescence and a portion attributable to background.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: January 7, 2003
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Todd E. French, Jon F. Petersen, John C. Owicki
  • Patent number: 6499366
    Abstract: Devices for automatically feeding sample containers into and out of an analyzer. The device may include (1) a first station that receives and initiates transport of a sample container into an analyzer for analysis, (2) a second station where the sample container is handed off to a transporter that carries the sample container to and from an examination site inside the analyzer, and (3) a third station that collects the sample container after examination. The device also may include a singulation mechanism configured to separate a sample container from a stack of sample containers, and/or a stacking mechanism configured to add a sample container to a stack of sample containers. The singulation and stacking mechanisms may include lifter and latch components.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: December 31, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: John W. Meadows, Glenn R. Edwards, Samuel A. Marquiss, Amer El-Hage, Douglas N. Modlin
  • Patent number: 6498335
    Abstract: A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments, the system includes apparatus and methods for automatically scaling the detection range to improve detection based on the intensity of the detected light. In yet other embodiments, the system includes apparatus and methods for detecting light with increased speed, particularly in applications involving analysis of successive samples.
    Type: Grant
    Filed: December 3, 2001
    Date of Patent: December 24, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, David P. Stumbo, Rick V. Stellmacher
  • Patent number: 6488892
    Abstract: Sample-holding devices and systems for efficiently utilizing relatively small-volume fluid samples.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: December 3, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: William G. Burton, Douglas N Modlin, Derrick A. Richardson, Jon F. Petersen, Joseph S. Leytes, John C. Owicki, Amer El-Hage, Lev J. Leytes
  • Patent number: 6486947
    Abstract: Devices and methods for containing and analyzing small sample volumes that are sandwiched between solid surfaces. The devices may include an automated drive mechanism that controls the relative positions of the surfaces and an environmental-control mechanism that controls the humidity, temperature, and/or other environmental conditions around the small sample volume. In some embodiments, at least one of the surfaces has a light-transmissive window for allowing optical analysis of a sample contained between the surfaces.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: November 26, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Amer El-Hage, John C. Owicki
  • Patent number: 6483582
    Abstract: Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take frequency-domain time-resolved measurements of one or more of luminescence lifetimes and reorientational correlation times of a luminescent analyte in the sample.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: November 19, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Todd E. French, John C. Owicki
  • Patent number: 6466316
    Abstract: Apparatus and methods for measuring light transmitted from a sample. The apparatus may include a stage, a light source, and a detector. The stage may be configured to hold a microplate having a plurality of sample wells. The apparatus may be configured to take measurements of one or more of absorbance, scattering, reflectance and luminescence. The apparatus may permit simultaneous measurements of two or more of these properties.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: October 15, 2002
    Assignee: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, Jon F. Petersen, John C Owicki
  • Publication number: 20020060791
    Abstract: Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio.
    Type: Application
    Filed: January 7, 2002
    Publication date: May 23, 2002
    Applicant: LJL BioSystems, Inc.
    Inventors: David P. Stumbo, Douglas N. Modlin
  • Publication number: 20020056803
    Abstract: A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments, the system includes apparatus and methods for automatically scaling the detection range to improve detection based on the intensity of the detected light. In yet other embodiments, the system includes apparatus and methods for detecting light with increased speed, particularly in applications involving analysis of successive samples.
    Type: Application
    Filed: December 3, 2001
    Publication date: May 16, 2002
    Applicant: LJL BioSystems, Inc.
    Inventors: Douglas N. Modlin, David P. Stumbo, Rick V. Stellmacher
  • Publication number: 20020009391
    Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
    Type: Application
    Filed: February 6, 2001
    Publication date: January 24, 2002
    Applicant: LJL BioSystems, Inc.
    Inventors: Samuel A. Marquiss, Christopher S. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Ley J. Leytes, Samuel Burd
  • Publication number: 20020006671
    Abstract: Improvements in luminescence polarization assays. The improvements may include using confocal optics to increase sensitivity and accuracy, providing additional classes of tracers, providing improved methods to prepare specific luminescent tracers, and/or expanding the scope of assay targets, among others.
    Type: Application
    Filed: January 25, 2001
    Publication date: January 17, 2002
    Applicant: LJL BioSystems, Inc.
    Inventors: J. Richard Sportsman, Lawrence M. Kauvar
  • Publication number: 20010048899
    Abstract: The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
    Type: Application
    Filed: February 5, 2001
    Publication date: December 6, 2001
    Applicant: LJL BioSystems, Inc.
    Inventors: Samuel A. Marouiss, Christopher G. Cesar, Jon F. Petersen, David P. Stumbo, Amer El-Hage, Glenn R. Edwards, Douglas N. Modlin, Lev J. Leytes, Samuel Burd
  • Patent number: 6326605
    Abstract: A broad-range light-detection system. In some embodiments, the system includes apparatus and methods for detecting light with high accuracy over a broad range of intensities. In other embodiments, the system includes apparatus and methods for automatically scaling the detection range to improve detection based on the intensity of the detected light. In yet other embodiments, the system includes apparatus and methods for detecting light with increased speed, particularly in applications involving analysis of successive samples.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: December 4, 2001
    Assignee: LJL Biosystems, Inc.
    Inventors: Douglas N. Modlin, David P. Stumbo, Rick V. Stellmacher
  • Publication number: 20010046673
    Abstract: Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 29, 2001
    Applicant: LJL BioSystems, Inc.
    Inventors: Todd E. French, Douglas N. Modlin, John C. Owicki, James S. Richey, Lev J. Leytes, Enal S. Razvi, Yan Zhang-Klompus, Peter R. Panfili