Abstract: Compound having the following structure: ##STR1## R is a direct chain or branched alkylene group comprising 2-8 carbon atoms,n and m are 0 or 1,Y is a carboxylic or phosphonic acid, andX is an active functional group which permits covalent coupling to a bio-organic molecule.

Abstract: A method of using a collection apparatus as well as the collection apparatus itself. The latter includes collection receptacles, a drip nozzle, and a component for bringing about a relative movement between the receptacles and the drip nozzle at predetermined times to collect the drops emitted by the drip nozzle, in the different receptacles. The time between the drops is measured by a time measurement circuit. The lower and the upper time limits for a time interval within which the next drop is expected, are calculated by a time limit calculating circuit. A blocking circuit is adapted to compare the time measured after the latest drop with the calculated time limits, and to block the relative movement when the measured time lies between these time limits. The blocking circuit is adapted to permit the relative movement when the expected drop has been emitted within the time limits.

Abstract: Method in a microtome, especially an ultramicrotome, in which a knife edge, turnable around its longitudinal axis, is used to cut sections from a specimen by making the specimen downwardly pass over the knife edge. The distance between the knife edge and the specimen before cutting is made extremely narrow without the specimen touching the knife. The slit is lit up from below by a light waveguide, one end of which is located under the knife edge and is turned with this and the other end of which is lit up by a light source movable in relation to the turning of the knife edge. The light from the waveguide is reflected against the surfaces of the knife as well as of the specimen which are turned towards the slit. The image of the knife surface reflected in the specimen surface, the size of which is proportional to the breadth of the slit, is viewed from at least one point located in a vertical plane outside of the vertical plane of the slit and on the same side of this as the knife.

Abstract: Process and apparatus for the staining of biological samples in which fluids of differing specific densities are successively introduced to the samples comprises a closed chamber to receive the samples for treatment, the chamber being provided with flow passages at the top and bottom and is in communication with an under pressure generating device so that fluids may be introduced into the chamber either from the top or the bottom depending upon whether a succeeding fluid is of lesser, or greater, specific density than the preceding fluid.

Abstract: A vessel for the growing of cells consists of an outer container provided with a lid which carries an inner container so as to form an annular growing vessel between the containers.

Abstract: A mould to be used for making specimen blocks for embedding specimens to be sectioned by a microtome, or ultramicrotome, is made from a soft heat resistant plastic to provide a number of cavities having the desired shape for the blocks to be moulded, the walls of the lowermost portions of the cavities being thin enough to be deformable by upward pressure on the exterior of the mould to remove the finished blocks with their embedded specimens.

Abstract: Apparatus for making glass knives for cutting specimens for viewing by optical microscopes from thin glass plates comprises the use of a breaking rule bearing against one side of a plate, at least two breaking knobs bearing against the other side of the plate on opposite sides of the breaking rule, and a scribing device arranged between the knobs to prepare a scribing line in the plate parallel with the breaking rule, the breaking rule being displaceable with respect to the scribing line to control the edge angle of the resulting knife.

Abstract: In an instrument for measuring radioactivity, the total measuring time for each sample is optimized by considering the maximum acceptable total counting error as well as the count rate. Each sample is counted for a period of time that is considerably shorter than the required measuring time but long enough to estimate the average pulse frequency, then the measuring time is determined as a function of the estimated pulse frequency and of the experimental error as determined by the channels ratio method.

Abstract: A method for the photometric determination of the subunit B of creatine kinase (CK-B) in buffered water solution through reaction with creatine phosphate, ADP and the system luciferase/D-luciferin in the presence of a specific antibody inhibiting the subunit M of creatine kinase, comprises making the determination in the presence of a D-luciferin analog, such as L-luciferin, having a structure similar to D-luciferin and being a competitive inhibitor of the firefly luciferase reaction.Also disclosed is a reagent for carrying out the above method comprising creatine-phosphate, ADP, luciferase, D-luciferin, L-luciferin, CK-M inhibiting antibodies, diadenosinpentaphosphate, SH-reagent, magnesium salt and buffer as well as possibly stabilizers and/or complex forming reagent.

Abstract: A triangular trough for collecting specimens from the knife edge of a microtome, or ultramicrotome is made of a form cast plastic material, one of the side walls projecting downwardly below the bottom wall of the trough to allow the trough to be adhesively attached to the side of the knife. The trough is inexpensive enough to be suitable for one time use.

Abstract: A device for transporting containers arranged in a spiral path past a fixed treatment station includes a carriage to support the containers in their spiral path, with a driving mechanism which rotates the carriage about a vertical axis while simultaneously shifting the axis in a horizontal direction to bring the containers successively to a predetermined location. The driving mechanism also includes a sensing device which can control the starting and stopping of the carriage's movements.

Abstract: The present invention refers to a device for stepwise displacement of a work-piece or a similar body, the device comprising a rod made from a reversibly expanding or compressing material coupled to an activation device whereby the rod has its ends resting in clamping brackets to be clamped alternatively at the expansion or compressing of the rod.

Abstract: A pipette having an axially displaceable piston is provided with a transversely displaceable stopping device for limiting the displacement of the piston in accordance with a volumetric scale marked on the stopping device. Operation of the piston and stopping device can be done with one hand.

Abstract: A calorimetric probe for measuring heat produced in a fluid consists of a tube through which the measured fluid flows and having two thermoelements at intervals spaced along the tube, each being connected between the tube and a surrounding element having good heat transmitting qualities, the surrounding element itself being separated from the first tube by a column of air so that a comparison of the readings of the two thermoelements provides a measure of heat developed in the liquid while passing between the two thermoelements.

Abstract: A method for adjusting the position of the transparent triangular knife of a microtome with respect to a sample to be sectioned, consists of projecting a beam of light into the interior of the knife from below whereby an area of the sample above the knife edge will be illuminated by refraction of the projected beam from the upper sloping surface of the knife, the darkened area of the sample between the knife edge and the illuminated area constituting a measurement of the horizontal distance between the sample and the knife.

Abstract: A method and apparatus for measuring temperature changes generated by enzyme activity consists in conducting a matrixbound enzyme through a flowpath formed by a helical coil and sensing the temperature in the immediate vicinity of the flowpath.

Abstract: According to the invention the specimen is given its desired design by pressing it towards a block, having a recess of the desired design and being cooled, preferably by liquid nitrogen.

Abstract: The present invention relates to the displacement of a workpiece in a given direction to a good accuracy. According to the invention the friction between the workpiece and a sliding surface on which the workpiece is resting is overcome by a mechanical impulse. Preferably, the mechanical impulse is accomplished by means of an electrical voltage pulse, by mechanical or piezoelectrical means.

Abstract: Apparatus for isotachophoretical separation consists of a capillary tube communicating with the sampling zone of a separating column between the leading and terminating electrolytes which are maintained at different electrical potentials.

Abstract: Apparatus for transporting sample containers past a treatment position consists of a rotatable stand in which the containers are supported adjacent to each other in a path running from the center of the stand toward its periphery, with a cam operated device for movably supporting a mouthpiece so as to follow the path of the containers as the stand is rotated.