Patents Assigned to Loma Linda University
  • Publication number: 20220071748
    Abstract: An evacuation dam apparatus including a frame having a top frame member, a bottom frame member, and two side frame members. A working area formed by the frame, a plurality of ports adjacent the working area, an outlet fluidly coupled with the plurality of ports. A fluid flow from at least a portion of the plurality of ports to the outlet forms a fluid flow path across the working area and at least a portion of the fluid flow path is formed within the frame.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 10, 2022
    Applicant: Loma Linda University
    Inventors: Abraham MONTALVO, Jessica KIM, Joseph CARUSO, Seth MYHRE, Roberto SAVIGNANO
  • Publication number: 20210322386
    Abstract: In one aspect, methods of reversing or delaying the progression of Alzheimer's disease in a subject having Alzheimer's disease or delaying the onset of Alzheimer's disease in a subject having mild cognitive impairment are provided. In some embodiments, the method comprises administering to the subject an oxysterol inhibitor.
    Type: Application
    Filed: June 10, 2019
    Publication date: October 21, 2021
    Applicant: Loma Linda University
    Inventors: Salvador SORIANO, Dong Kyu SHIN, Karina MAYAGOITIA
  • Patent number: 11080554
    Abstract: Embodiments provide techniques, including systems and methods, for processing imaging data to identify an installed component. Embodiments include a component identification system that is configured to receive imaging data including an installed component, extract features of the installed component from the imaging data, and search a data store of components for matching reference components that match those features. A relevance score may be determined for each of the reference components based on a similarity between the image and a plurality of reference images in a component model of each of the plurality of reference components. At least one matching reference component may be identified by comparing each relevance score to a threshold relevance score and matching component information may be provided to an end-user for each matching reference component.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: August 3, 2021
    Assignee: LOMA LINDA UNIVERSITY
    Inventors: Montry Suprono, Robert Walter
  • Publication number: 20210137763
    Abstract: The disclosure is related to a system and method for operating a traction device to detect blood flow patterns in a subject for managing neuropathy related conditions through intraneural facilitation (INF). According to an embodiment, the INF system and method rely on the traction device for positioning the subject in one or more positions, and a processing device for processing intervening signals obtained by a probe positioned on the subject. The signals received from the probe may be used to determine a two dimensional (2D) plane blood flow pattern. Detected changes in the measured blood flow may be used to determine if further traction device positions are required to ensure that the intervening signals demonstrate normal blood flow patterns with improvements to the neuropathy condition. The 2D flow pattern may calculate at least one of Volume Flow (VF) and Pulsatility Index (PI) for each set of signals received.
    Type: Application
    Filed: April 23, 2019
    Publication date: May 13, 2021
    Applicant: LOMA LINDA UNIVERSITY
    Inventor: Mark BUSSELL
  • Patent number: 10932816
    Abstract: A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: March 2, 2021
    Assignees: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE, LOMA LINDA UNIVERSITY
    Inventors: Dalton Duane Baldwin, Alexander Yeo, Jacob Martin
  • Patent number: 10857381
    Abstract: Embodiments of systems and methods for an integrated phototherapy system that can include integrating a bili light, radiometer, and transcutaneous bilirubin sensor are disclosed. In some embodiments, the integrated phototherapy system has a control system that can receive and send data and automate features of the phototherapy system. Data that can be input by a healthcare provider and/or measured by the system can include treatment time, distance between the patient and the bili light, intensity level, irradiance level, bilirubin level, temperature, and the light intensity or irradiance of other light sources or pieces of equipment. The phototherapy system can be compatible with any electronic healthcare records system, and measured data can aggregated and uploaded to such a system.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 8, 2020
    Assignee: LOMA LINDA UNIVERSITY
    Inventor: Janel A. Duggins
  • Patent number: 10842474
    Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: November 24, 2020
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventor: Dalton Duane Baldwin
  • Patent number: 10816190
    Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: October 27, 2020
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Dalton Duane Baldwin, Michael R. Samardzija, Zoran Zivanovic
  • Patent number: 10813987
    Abstract: The subject technology relates generally to compositions and methods for producing plasmid DNA of a desired quality. In addition, it relates to the discovery of Escherichia coli (E. coli) bacteria with a constitutive methylase gene stably incorporated into the chromosomal DNA and uses thereof.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 27, 2020
    Assignee: Loma Linda University
    Inventor: Alan P. Escher
  • Patent number: 10792067
    Abstract: A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy is disclosed. The method includes selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: October 6, 2020
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY OF MEDICINE
    Inventors: Dalton Duane Baldwin, Avijit Mukherjee, Steven Mark Redenbaugh, Ronald Steven Pirucki, James Watson
  • Publication number: 20200080718
    Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 12, 2020
    Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Dalton Duane BALDWIN, Michael R. SAMARDZIJA, Zoran ZIVANOVIC
  • Patent number: 10577669
    Abstract: Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 3, 2020
    Assignee: Loma Linda University
    Inventors: Xiaolei Tang, David J. Baylink, K.-H. William Lau, Michael Walter
  • Publication number: 20200009289
    Abstract: In one aspect, compositions for promoting hemostasis are provided. In some embodiments, the composition comprises a porous non-fibrous substrate impregnated with a hemostatic agent, wherein the porous non-fibrous substrate comprises a hydrophilic polyurethane foam. Methods of promoting hemostasis in a subject using such compositions, and methods of manufacturing such compositions, are also provided.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 9, 2020
    Applicant: LOMA LINDA UNIVERSITY HEALTH
    Inventors: Mahmoud TORABINEJAD, Richard MASKIEWICZ
  • Patent number: 10527277
    Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: January 7, 2020
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Dalton Duane Baldwin, Michael R. Samardzija, Zoran Zivanovic
  • Patent number: 10500258
    Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipient, as described herein, can induce a donor specific tolerogenic response.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 10, 2019
    Assignee: Loma Linda University
    Inventors: Fengchun Li, Alan P. Escher
  • Publication number: 20190323703
    Abstract: A system and method of illuminating one or more foot pedals with an optically brightened layer positioned to fluoresce responsive to activation of one or more ultraviolet (UV) illuminating devices positioned adjacent or attached to the one or more foot pedals. The optically brightened layer may include an optically brightened coating covering at least a portion of each of the one or more foot pedals, or may include an optically brightened material layer positioned to cover and protect each of the one or more foot pedals from debris or moisture during use. A friction portion may be attached to the optically brightened material layer, the friction portion being positioned adjacent a lower surface of the foot pedal when the optically brightened material layer surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.
    Type: Application
    Filed: October 24, 2018
    Publication date: October 24, 2019
    Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Dalton Duane BALDWIN, Michael R. SAMARDZIJA, Zoran ZIVANOVIC
  • Publication number: 20190303712
    Abstract: Embodiments provide techniques, including systems and methods, for processing imaging data to identify an installed component. Embodiments include a component identification system that is configured to receive imaging data including an installed component, extract features of the installed component from the imaging data, and search a data store of components for matching reference components that match those features. A relevance score may be determined for each of the reference components based on a similarity between the image and a plurality of reference images in a component model of each of the plurality of reference components. At least one matching reference component may be identified by comparing each relevance score to a threshold relevance score and matching component information may be provided to an end-user for each matching reference component.
    Type: Application
    Filed: December 19, 2017
    Publication date: October 3, 2019
    Applicant: LOMA LINDA UNIVERSITY
    Inventors: Montry SUPRONO, Robert WALTER
  • Patent number: 10405943
    Abstract: A kit for performing a reduced radiation percutaneous procedure is provided. The kit includes a needle access device having a needle connected to a hub portion having an opaque cap portion, a non-opaque body portion positioned between the opaque cap portion and the needle, and a channel extending through the opaque cap portion; a sticker having an adhesive side adapted to adhere to the skin of a patient, and a display surface opposite the adhesive side configured to enhance visualization of the sticker in low light; and a guidewire having a floppy portion with a distal end, an intermediate region connected to the floppy portion, such that the intermediate region is less floppy than the floppy portion; and an ultrasonic-profile-enhancing feature disposed within 3 centimeters of the distal end of the floppy portion.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: September 10, 2019
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventor: Dalton Duane Baldwin
  • Patent number: 10371370
    Abstract: A system and method of illuminating a foot pedal with an illuminated protective covering. The illuminated protective covering can include a plurality of illuminating devices surrounding at least a majority of a perimeter of the foot pedal. The illuminated protective covering can also include a sheet surrounding the upper surface and the lower surface of the foot pedal and the plurality of illuminating devices, the sheet being configured to protect the foot pedal from debris during use. A friction portion can be attached to the sheet, the friction portion being positioned on the sheet such that the friction portion is adjacent the bottom surface of the foot pedal when the sheet surrounds the foot pedal, the friction portion being configured to prevent sliding of the foot pedal against the floor or other surface.
    Type: Grant
    Filed: July 28, 2018
    Date of Patent: August 6, 2019
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventor: Dalton Duane Baldwin
  • Patent number: 10299771
    Abstract: Surgical tools for use during scarless or near scarless surgical procedures. At least some of the surgical tools can include a handle portion and a working end removably connected to the handle portion.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: May 28, 2019
    Assignee: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
    Inventor: Dalton Duane Baldwin