Patents Assigned to Louisiana State University
  • Patent number: 11510925
    Abstract: The presently claimed invention is related to compositions and methods for treating H2S related diseases comprising administering a pharmacologically effective amount of pharmaceutical composition containing a first therapeutic, wherein the first therapeutic includes one of an ATR kinase inhibitor and an ATR kinase promotor. According to further embodiments the H2S related disease is one of cancer, cardiovascular disease, acute inflammation, chronic inflammation, and neurological disease.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: November 29, 2022
    Assignee: Board of Supervisors of Louisiana State University
    Inventors: Christopher G. Kevil, Rodney Shackelford
  • Patent number: 11497775
    Abstract: This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: November 15, 2022
    Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: David J. Lefer, David J. Polhemus
  • Patent number: 11493515
    Abstract: This invention comprises compositions and methods to detect and treat gastrointestinal diseases.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: November 8, 2022
    Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Sunyoung Kim, Zeromeh Gerber, Duna Penn, Carl Sabottke, Rebecca Buckley
  • Patent number: 11490570
    Abstract: Various examples of methods and systems are provided for increasing productivity of one or more photosynthetic cultures via self-powered energy output systems. In one example, a system includes a waterproof casing and an energy output module enclosed within the waterproof casing. The waterproof casing is configured to be neutrally buoyant in an enclosure comprising the one or more photosynthetic cultures. In another example, a method includes placing a self-powered energy output system within an enclosure, the self-powered energy output system being neutrally buoyant within the enclosure. The method further includes causing turbulence within the enclosure, and the self-powered energy output system harvests energy to power the self-powered energy output system via the turbulence within the enclosure.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: November 8, 2022
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: Maria Teresa Gutierrez-Wing, Jin-Woo Choi
  • Patent number: 11488740
    Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: November 1, 2022
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Joyoni Dey, Narayan Bhusal, Leslie Butler, Jonathan P. Dowling, Kyungmin Ham, Varshni Singh
  • Patent number: 11488420
    Abstract: Methods of estimating tribological damage described herein include examples where varying power is applied between surfaces engaged in frictional contact. Calculations evaluate power consumed at the relevant frictional contact and temperature values may be gathered to supplement the calculated power. Instantaneous and cumulative assessments of damage are calculated based on that information. Measurements or calculations of electrical power may be used as part of the damage assessment.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: November 1, 2022
    Assignee: Board af Supervisors af Louisiana State University and Agricultural and Mechanical College
    Inventors: Michael M. Khonsari, Lijesh Koottaparambil
  • Publication number: 20220330398
    Abstract: The absorbance or emission wavelength of composite materials comprising a transition metal doped shell disposed over a rare earth doped core and a functionalizable group on the surface of the transition metal doped shell can change upon subjection to a carboxylic acid. This method of changing the absorbance or emission wavelength of a composite material can be used to identify counterfeit currency using an ink comprising a composite material.
    Type: Application
    Filed: April 14, 2022
    Publication date: October 13, 2022
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: James Anthony Dorman
  • Patent number: 11464740
    Abstract: Methods and monodisperse glass microsphere composites comprising a porous wall hollow-glass microsphere; a cargo of a therapeutic is loaded inside of the porous wall hollow-glass microsphere; and a first shell fully encapsulating the porous wall hollow-glass microsphere and capping pores in the walls, retaining the cargo inside of the porous wall hollow-glass microsphere.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: October 11, 2022
    Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, APPLIED RESEARCH CENTER, INC.
    Inventors: Paul M. Weinberger, George Wicks, William D. Hill
  • Patent number: 11458142
    Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: October 4, 2022
    Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala De Henares, South Rampart Pharma, LLC
    Inventors: Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla, Dennis Paul, Carolina Burgos
  • Publication number: 20220280618
    Abstract: The present invention is directed to antibodies binding to and neutralizing Candida and methods for use thereof.
    Type: Application
    Filed: July 28, 2020
    Publication date: September 8, 2022
    Applicants: The Administrators of the Tulane Educational Fund, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Autoimmune Technologies, LLC
    Inventors: Russell B. WILSON, Hong XIN, James E. ROBINSON
  • Publication number: 20220273702
    Abstract: Therapeutics and methods of treating COVID-19 comprising in a patient comprising administering to the patient an effective dose of a pharmacologic composition containing a first therapeutic; wherein the first therapeutic is a hydrogen sulfide (H2S) donor, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. According to a further embodiment the H2S donor is one of include diallyl trisulfide (DATS), diallyl disulfide (DADS), sodium sulfide, acillin, sugammadex, sulfanilamide, disulfram, sulfonamide, a sulfinate, a sulfoxide, a persulfide, a polysulfide, and a sulfone. According to a further embodiment the pharmacologic composition further contains a second therapeutic, wherein the second therapeutic is a nitrite, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. According to a further embodiment wherein the nitrite is an inorganic nitrite.
    Type: Application
    Filed: February 25, 2022
    Publication date: September 1, 2022
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Gopi K. Kolluru, Christopher KEVIL, Paari DOMINIC, Anthony Wayne ORR
  • Patent number: 11427711
    Abstract: A composition for sealing defects in structural materials such as roads or paved surfaces, the composition preferably comprising one or more shape memory polymer (SMP) components capable of responding to increased temperature by decreasing in volume.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: August 30, 2022
    Assignee: Board of Supervisors of Louisiana State University
    Inventor: Guoqiang Li
  • Publication number: 20220243040
    Abstract: Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 4, 2022
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Sharareh Shirzad, Marwa M. Hassan
  • Publication number: 20220241401
    Abstract: The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.
    Type: Application
    Filed: December 14, 2021
    Publication date: August 4, 2022
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Konstantin G. Kousoulas
  • Publication number: 20220233743
    Abstract: A composition for wound healing, comprising an amount of a macrophage proresolving polarizer, wherein the amount is effective to promote wound healing. The composition includes wherein the macrophage proresolving polarizer is lipin-1. The composition includes wherein the composition includes one, two, or three of IL-4, apoptotic cells (ACs), and AC derived lipids. The composition includes wherein the macrophage proresolving polarizer is a lipin-1 transcriptional coregulatory activity promoter. The composition includes, wherein the lipin-1 transcriptional coregulatory activity promoter is an inhibitor of lipin-1 macrophage pro-inflammatory responses enzymatic activity. A method for promoting wound healing, comprising contacting a wound on a skin of a mammal with the composition. A kit comprising one or more containers including the composition in sterile packaging.
    Type: Application
    Filed: December 14, 2020
    Publication date: July 28, 2022
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Matthew WOOLARD, Robert SCHILKE, Cassidy BLACKBURN
  • Patent number: 11392734
    Abstract: Embodiments of the present invention include apparatuses and methods for performing remote experiments in real-time. The method includes sending requests to perform remote experiments for a desired configuration to a first and second facility. The desired configuration may include a first and second configuration. The method includes running a first remote experiment in real-time at the first facility to obtain a first output variable. The first facility may include the first configuration with a first input variable. The method includes simultaneously running a second remote experiment in real-time at a second facility to obtain a second output variable. The second facility may include the second configuration with a second input variable. The first output variable may be set as the second input variable to mimic the desired configuration. The method includes obtaining experimental results of the desired configuration via the first and second input and output variables.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 19, 2022
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventor: Paulo J. Waltrich
  • Patent number: 11384019
    Abstract: High-strength concrete-like FG blends and methods for producing them are described. The blend includes FG, hydraulic cement, additional alkali material, and pozzolanic material. The blend further includes an admixture used in the formulation of concrete. The blend further includes an aggregate. The aggregate is a coarse aggregate or a fine aggregate.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: July 12, 2022
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Michele Barbato, Yasser Bigdeli, Maria Teresa Gutierrez-Wing, Charles Davis Lofton
  • Patent number: 11376573
    Abstract: Methods of preparing an acidic catalyst are disclosed that include heating a metal halide to produce a vapor phase metal halide, contacting an initial support material with the vapor phase metal halide in a reaction vessel causing a first chemical reaction and producing an intermediate acidic catalyst, contacting the intermediate acidic catalyst with HBr causing a second chemical reaction and producing an acidic catalyst product which is both more acidic than the intermediate acidic catalyst and more acidic than the initial support material.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: July 5, 2022
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: James J. Spivey, Kunlun Ding, Swarom Kanitkar
  • Patent number: 11371913
    Abstract: The present disclosure provides for sampling instruments and methods of collecting sample particles. The sampling instrument can include a high-pressure pulsed valve coupled to a gas flow system to displace a sample from a surface. Also included can be a voltage supply coupled to a voltage switch, a suction device, a sample collector, and a collection filter. To collect a sample, extractive particles can be deposited onto a sample present on a substrate. At least a portion of the sample becomes coupled to a portion of the extractive particles to form sample particles. High-pressure gas can be discharged at the sample, thereby aerosolizing a portion of the sample particles to disperse aerosolized sample particles. A portion of the aerosolized sample particles can be collected onto a collection filter to form a collected sample.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: June 28, 2022
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
    Inventors: Kermit King Murray, Fabrizio Donnarumma, Jamira Stephenson
  • Publication number: 20220193105
    Abstract: The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (10) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds.
    Type: Application
    Filed: March 1, 2021
    Publication date: June 23, 2022
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Shenuarin BHUIYAN, Mohuddin QUADAIR