Patents Assigned to Lunan Pharmaceutical Group Corporation
  • Patent number: 11795174
    Abstract: Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation: wherein R1 is selected from hydrogen, halogen, alkyl, cyano and haloalkyl, R2 and R3 are independently selected from hydrogen, halogen, alkyl, haloalkyl and nitro, and R1, R2 and R3 are not hydrogen at the same time; furthermore, when either R2 or R3 is nitro or halogen, the other two of R1, R2 and R3 are not hydrogen at the same time. The compound has good effects in treating a neuropathic pain and/or neuropathic pain syndrome and good effects in combating an inflammation, and has not side effects such as addiction.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 24, 2023
    Assignee: LUNAN PHARMACEUTICAL GROUP CORPORATION
    Inventors: Runtao Li, Jia Ye, Xin Wang, Zemei Ge, Yingying Liang, Xiaolei Du, Ding Wang, Guimin Zhang, Jingchun Yao, Guifang Zhao
  • Publication number: 20230103858
    Abstract: The present disclosure provides use of icaritin in preparing a drug for preventing and treating a bleeding disorder and belongs to the field of medicine. The icaritin can relieve platelet dysfunction, shorten thromboplastin time, and promote blood coagulation, and can be used for preventing and treating the bleeding disorder, especially for treating hemorrhagic transformation after cerebral infarction, gastrointestinal bleeding caused by a thrombolytic or antithrombotic drug for cerebral infarction, or a bleeding complication of a thrombolytic or antithrombotic drug for myocardial infarction.
    Type: Application
    Filed: March 9, 2021
    Publication date: April 6, 2023
    Applicant: Lunan Pharmaceutical Group Corporation
    Inventors: Guimin Zhang, Jingchun Yao, Chenghong Sun, Bin Li, Sina Pan
  • Publication number: 20200369674
    Abstract: Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation: wherein R1 is selected from hydrogen, halogen, alkyl, cyano and haloalkyl, R2 and R3 are independently selected from hydrogen, halogen, alkyl, haloalkyl and nitro, and R1, R2 and R3 are not hydrogen at the same time; furthermore, when either R2 or R3 is nitro or halogen, the other two of R1, R2 and R3 are not hydrogen at the same time. The compound has good effects in treating a neuropathic pain and/or neuropathic pain syndrome and good effects in combating an inflammation, and has not side effects such as addiction.
    Type: Application
    Filed: December 7, 2018
    Publication date: November 26, 2020
    Applicant: LUNAN PHARMACEUTICAL GROUP CORPORATION
    Inventors: Runtao LI, Jia YE, Xin WANG, Zemei GE, Yingying LIANG, Xiaolei DU, Ding WANG, Guimin ZHANG, Jingchun YAO, Guifang ZHAO
  • Patent number: 10799521
    Abstract: The present application relates to a method of icaritin in preventing or treating hematocytopenia. Particularly, icaritin may be used to prevent or treat bone marrow suppression caused by chemotherapeutic drugs, and may also be used to prevent or treat thrombocytopenia, for example, immune thrombocytopenia.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 13, 2020
    Assignee: LUNAN PHARMACEUTICAL GROUP CORPORATION
    Inventors: Zhiquan Zhao, Jingchun Yao, Xin Li, Yongxia Guan, Guangyan Li
  • Patent number: 10555962
    Abstract: The present application relates to use of icaritin in preparing a medicament for preventing or treating hematocytopenia. Particularly, icaritin may be used to prevent or treat bone marrow suppression caused by chemotherapeutic drugs, and may also be used to prevent or treat thrombocytopenia, for example, immune thrombocytopenia.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: February 11, 2020
    Assignee: Lunan Pharmaceutical Group Corporation
    Inventors: Zhiquan Zhao, Jingchun Yao, Xin Li, Yongxia Guan, Guangyan Li
  • Publication number: 20160250243
    Abstract: The present application relates to use of icaritin in preparing a medicament for preventing or treating hematocytopenia. Particularly, icaritin may be used to prevent or treat bone marrow suppression caused by chemotherapeutic drugs, and may also be used to prevent or treat thrombocytopenia, for example, immune thrombocytopenia.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 1, 2016
    Applicant: Lunan Pharmaceutical Group Corporation
    Inventors: Zhiquan ZHAO, Jingchun YAO, Xin LI, Yongxia GUAN, Guangyan LI
  • Patent number: 8815286
    Abstract: The present invention provides a pharmaceutical composition comprising the following active ingredients: 1) an angiotensin II receptor antagonist or a pharmaceutically acceptable salt thereof, 2) pioglitazone or a pharmaceutically acceptable salt thereof; and 3) rosuvastatin or a pharmaceutically acceptable salt thereof. The present invention also provides use of the pharmaceutical composition in preparing a medicament for treating hypertension or metabolic syndrome. The pharmaceutical composition of the present invention can treat hypertension or metabolic syndrome, while effectively controlling the incidence of associated cardiovascular diseases and more potently improving survival prognosis in hypertensive patients. When blood pressure is lowered to desired level, the risk factors such as cardiovascular diseases are rectified, metabolic disorders and prognosis of patients are improved, and survival rate of hypertensive patients is raised.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: August 26, 2014
    Assignee: Lunan Pharmaceutical Group Corporation
    Inventor: Zhiquan Zhao
  • Patent number: 8722697
    Abstract: The present invention provides a pharmaceutical composition comprising the following active ingredients: 1) amlodipine or a pharmaceutically acceptable salt thereof, 2) pioglitazone or a pharmaceutically acceptable salt thereof, and 3) rosuvastatin or a pharmaceutically acceptable salt thereof. The present invention also provides use of the pharmaceutical composition in preparing a medicament for treating hypertension or metabolic syndrome. The pharmaceutical composition of the present invention can treat hypertension or metabolic syndrome, while effectively controlling the incidence of associated cardiovascular diseases and more potently improving survival prognosis in hypertensive patients. When blood pressure is lowered to desired level, the risk factors such as cardiovascular diseases are rectified, metabolic disorders and prognosis of patients are improved, and survival rate of hypertensive patients is raised.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: May 13, 2014
    Assignee: Lunan Pharmaceutical Group Corporation
    Inventor: Zhiquan Zhao
  • Patent number: 8361965
    Abstract: A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.
    Type: Grant
    Filed: February 18, 2008
    Date of Patent: January 29, 2013
    Assignees: Lunan Pharmaceutical Group Corporation, Fagen Biomedical Inc. Chongqing
    Inventors: Kai Fan, Zhiquan Zhao
  • Publication number: 20100150860
    Abstract: Provided is a chimeric protein comprising neutrophil inhibitory factor, the peptide FRRP specially recognizing the thrombin active site and hirugen. Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, inhibiting platelet aggregation etc.
    Type: Application
    Filed: February 18, 2008
    Publication date: June 17, 2010
    Applicants: Lunan Pharmaceutical Group Corporation, Fagen Biomedical Inc.
    Inventors: Kai Fan, Zhiquan Zhao