Patents Assigned to Martek Biosciences
  • Publication number: 20130190399
    Abstract: The invention provides methods of synthesizing omega-3 and omega-6 very long chain polyunsaturated fatty acids (VLC-PUFAs, C28-C42:4, 5 and 6), analogs and derivatives thereof, pharmaceutical compositions containing these isolated VLC-PUFA compounds and therapeutic uses therefor.
    Type: Application
    Filed: April 30, 2012
    Publication date: July 25, 2013
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Krishna Raman, Vinod Tarwade
  • Patent number: 8221809
    Abstract: Products comprising labile compounds, such as polyunsaturated fatty acids, and having first and second encapsulants are disclosed. A first encapsulant can be a spray dried coating and the second encapsulant can be a prill coating. Methods of making the same are provided.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: July 17, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Srinivasan Subramanian, Brian J. Connolly, William A. Hendrickson
  • Publication number: 20120178135
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Application
    Filed: January 3, 2012
    Publication date: July 12, 2012
    Applicant: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, Jon M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Patent number: 8216812
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: July 10, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Patent number: 8207363
    Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: June 26, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Kirk E. Apt, Joseph W. Pfeifer, III, Jon Milton Hansen, Paul Warren Behrens, Ross Zirkle, Tracey Lynn Stahl
  • Patent number: 8206956
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: June 26, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Publication number: 20120135106
    Abstract: The present invention includes a palatable, stable composition comprising a biomass hydrolysate emulsion for incorporation, into, or used as, nutritional products, cosmetic products or pharmaceutical products. Preferred sources for biomass are microbial sources, plant sources and animal sources. The present invention also provides methods for making such compositions, specifically, a method for producing a product comprising a nutrient, particularly a long chain polyunsaturated fatty acid, comprising hydrolyzing a biomass comprising the nutrient and emulsifying the hydrolyzed biomass. Such compositions and methods are useful, for example, for increasing intake of nutrients such as omega-3 long chain polyunsaturated fatty acids having 18 or more carbons.
    Type: Application
    Filed: October 31, 2011
    Publication date: May 31, 2012
    Applicant: Martek Biosciences Corporation
    Inventors: Jaouad FICHTALI, Micah Hazzy NEEDHAM, Henry LINSERT, JR.
  • Patent number: 8187846
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: May 29, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Patent number: 8187845
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: May 29, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Publication number: 20120128850
    Abstract: According to one embodiment, a food product comprises a non-fat base, one or more polyunsaturated fatty acids, and one or more stabilizing ingredients. The stabilizing ingredients are selected to reduce the rate at which the polyunsaturated fatty acids oxidize in the non-fat base. At least one of the one or more stabilizing ingredients comprises a protein, a lipid, or a protein-and-lipid combination.
    Type: Application
    Filed: February 28, 2011
    Publication date: May 24, 2012
    Applicants: Martek Biosciences Corporation, Whitewave Services, Inc.
    Inventors: Suzy Xiaoqing Zeng, Georgia A. Anderson, Jesus Ruben Abril, Wei Wang-Nolan
  • Patent number: 8133706
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: March 13, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Publication number: 20120059180
    Abstract: A process for purifying a lipid composition having predominantly neutral lipid components having at least one long chain polyunsaturated fatty acid is disclosed. The process employs contacting the lipid composition with a polar solvent, such as acetone, wherein the solvent is selected such that contaminants are less soluble in the solvent than is the long chain polyunsaturated fatty acid. The process is typically conducted at cooler temperatures, including about 0° C. Upon precipitation of the contaminants from the lipid composition, a separation is conducted to remove the precipitated material from the lipid composition. The long chain polyunsaturated fatty acids can include ARA, DPA, EPA, and/or DHA. The process of the present invention effectively winterizes lipid compositions, thereby reducing the tendency of such compositions to become hazy.
    Type: Application
    Filed: September 6, 2011
    Publication date: March 8, 2012
    Applicant: Martek Biosciences Corporation
    Inventors: Daniel G. DUEPPEN, Samuel G. Zeller, Sandra I. Diltz, Robert H. Driver
  • Patent number: 8129172
    Abstract: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful for the production of food products for use in aquaculture. Further disclosed is a food product which includes Thraustochytrium, Schizochytrium, and mixtures thereof, and a component selected from flaxseed, rapeseed, soybean and avocado meal. Such a food product includes a balance of long chain and short chain omega-3 highly unsaturated fatty acids.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: March 6, 2012
    Assignee: Martek Biosciences Corporation
    Inventor: William R. Barclay
  • Patent number: 8124384
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: February 28, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Patent number: 8124385
    Abstract: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: February 28, 2012
    Assignee: Martek Biosciences Corporation
    Inventors: Richard B. Bailey, Don DiMasi, John M. Hansen, Peter J. Mirrasoul, Craig M. Ruecker, George T. Veeder, III, Tatsuo Kaneko, William R. Barclay
  • Publication number: 20120034653
    Abstract: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human and Chlorella kessleri glucose transporters facilitated the uptake of glucose by P. tricornutum, allowing the cells to metabolize exogenous organic carbon and thrive, independent of light. This is the first successful trophic conversion of an obligate photoautotroph through metabolic engineering, and it demonstrates that methods of cell nourishment can be fundamentally altered with the introduction of a single gene. Since strains transformed with the glucose transport genes are able to grow non-photosynthetically, they can be exploited for the analysis of photosynthetic processes through mutant generation and characterization.
    Type: Application
    Filed: July 22, 2011
    Publication date: February 9, 2012
    Applicant: Martek Biosciences Corporation
    Inventors: Kirk Emil APT, F.C. Thomas Allnutt, David J. Kyle, James Casey Lippmeier
  • Publication number: 20120021470
    Abstract: Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.
    Type: Application
    Filed: June 27, 2011
    Publication date: January 26, 2012
    Applicant: Martek Biosciences Corporation
    Inventors: Craig A. WEAVER, Ross Zirkle, Daniel H. Doherty, James G. Metz
  • Patent number: 8048652
    Abstract: The present invention includes a palatable, stable composition comprising a biomass hydrolysate emulsion for incorporation, into, or used as, nutritional products, cosmetic products or pharmaceutical products. Preferred sources for biomass are microbial sources, plant sources and animal sources. The present invention also provides methods for making such compositions, specifically, a method for producing a product comprising a nutrient, particularly a long chain polyunsaturated fatty acid, comprising hydrolyzing a biomass comprising the nutrient and emulsifying the hydrolyzed biomass. Such compositions and methods are useful, for example, for increasing intake of nutrients such as omega-3 long chain polyunsaturated fatty acids having 18 or more carbons.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: November 1, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: Jaouad Fichtali, Micah Hazzy Needham, Henry Linsert, Jr.
  • Patent number: 8039030
    Abstract: Microwaveable popcorn compositions, products and methods of making the same are disclosed. The composition includes unpopped popcorn kernels, an oil comprising at least one omega-3 LC PUFA, and an oil that is solid at about 20° C. The an oil comprising at least one omega-3 LC PUFA can include a microbial oil prepared by extraction with isopropanol and water in the absence of winterization.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: October 18, 2011
    Assignee: Martek Biosciences Corporation
    Inventors: Jesus Ruben Abril, Thayne Fort
  • Publication number: 20110250342
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from Schizochytrium, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Application
    Filed: January 18, 2011
    Publication date: October 13, 2011
    Applicant: Martek Biosciences Corporation
    Inventors: James G. Metz, James H. Flatt, Jerry M. Kuner, William R. Barclay