Abstract: A compliant prosthetic foot is designed and fabricated by combining a compliant mechanism optimization technique with a calculation of low leg trajectory error under a reference loading condition. The compliant mechanism optimization technique includes a set of determinants for the compliant prosthetic foot. An optimized set of determinants of the compliant prosthetic foot is formed that minimizes the lower leg trajectory error relative to a target kinematic data set. The compliant prosthetic foot is then fabricated in conformance with the optimized set of determinants.
Abstract: A power generator includes a plurality of amplifier blocks and a combiner. Each of the amplifier blocks include one or more amplifiers, and the combiner combines modulated power signals output from the amplifier blocks to generate an RF power signal of a load. The amplifier blocks are controlled to outphase the modulated power signals based on a phase angle. Ones of the amplifier blocks may perform discrete modulation to generate a respective one of the modulated power signals. The discrete modulation includes selecting different combinations of the amplifiers in one or more of the amplifier blocks to change the RF power signal in discrete steps. In embodiments, the amplifiers may be radio frequency power amplifiers.
Type:
Application
Filed:
May 17, 2024
Publication date:
September 12, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Haoquan Zhang, Anas Al Bastami, David J. Perreault
Abstract: The invention relates to compositions and methods for targeting polynucleotides with eukaryotic RNA-guided nucleases. In particular, programmable RNA-guided DNA endonucleases termed Fanzors, can be harnessed for genome editing.
Type:
Application
Filed:
January 5, 2024
Publication date:
September 12, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Omar Abudayyeh, Jonathan Gootenberg, Justin Lim, Kaiyi Jiang
Abstract: A multi-sensor, real-time, in-process current and voltage estimation system is disclosed including sensors, affiliated hardware, and data processing algorithms that allow accurate estimation of currents and voltages from magnetic and electric field measurements, respectively. Aspects of the system may be embodied in a detector that is readily attachable to conductors of an energized system for contactless current and/or voltage sensing of the conductors without requiring the conductors to be disconnected from the energized system.
Type:
Grant
Filed:
January 4, 2023
Date of Patent:
September 10, 2024
Assignees:
HARTING Electric Stiftung & Co. KG, The Massachusetts Institute of Technology
Inventors:
Vivek R. Dave, Felix Loske, Enger Knop, Lutz Tröger, Alan E. Casallas, Jeffrey H. Lang
Abstract: The use of elongated nanostructures in separators and associated devices and methods, including devices and methods for energy storage and/or use, are generally described. According to certain embodiments, the elongated nanostructures can extend from a first solid substrate to a second solid substrate. In some embodiments, the nanostructures penetrate a surface of the first solid substrate (e.g., a first electrode) and/or a surface of the second solid substrate (e.g., a second electrode). The elongated nanostructures can, according to certain embodiments, provide structural reinforcement between two substrates (e.g., between two electrodes) while maintaining electronic insulation between the two substrates.
Abstract: The present disclosure provides enynes, end-functionalized polymers, conjugates, methods of preparation, compositions, kits, and methods of use. The conjugates comprise at least (1) a peptide (e.g., an antibody), protein, nucleoprotein, mucoprotein, lipoprotein, glycoprotein, or polynucleotide; and (2) a polymer comprising a pharmaceutical agent. The conjugates may be useful in delivering (e.g., targeted delivering) the pharmaceutical agent to a subject in need thereof or cell or treating, preventing, or diagnosing a disease.
Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
Abstract: The present disclosure provides methods and systems for profiling RNAs being translated in a cell. Also provided by the present disclosure are methods for diagnosing a disease or disorder in a subject based on a profile of the RNAs being translated in a cell, including cells within an intact tissue. Methods of screening for or testing a candidate agent capable of modulating translation of one or more RNAs are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder in a subject in need thereof. Pairs of probes and sets of probes comprising oligonuclcotide portions, which may be useful for performing the methods described herein, are also described by the present disclosure. Additionally, the present disclosure provides kits comprising any of the probes described herein.
Type:
Application
Filed:
June 28, 2022
Publication date:
September 5, 2024
Applicants:
The Broad Institute, Inc., Massachusetts Institute of Technology
Abstract: Disclosed herein are articles, systems, and methods for the injection of viscous fluids. For example, inventive articles, systems, and methods for injecting viscous fluids, such as concentrated drug formulations, via droplet lubrication are described.
Type:
Application
Filed:
April 11, 2022
Publication date:
September 5, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Kripa K. Varanasi, Vishnu Jayaprakash, Simon B. Rufer
Abstract: Compositions and methods of use related to metal organic frameworks (MOFs) and/or nanoparticles are generally described. In some embodiments, methods and compositions for the catalytic upgrading of alcohols using MOFs and/or nanoparticles associated with MOFs are generally described. In some embodiments, a catalytic MOF composition is provided, wherein the MOF composition comprises a MOF compound and a plurality of metal catalytic compounds. In some embodiments, an alcohol may be exposed to the MOF composition and/or a plurality of nanoparticles associated with the MOF composition such that the alcohol is converted to a higher order alcohol. Advantageously, in some embodiments, the alcohol conversion occurs at a relatively high turnover frequency and/or with a relatively high selectivity as compared to traditional methods for converting alcohols.
Abstract: The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
December 19, 2023
Publication date:
September 5, 2024
Applicants:
Translate Bio, Inc., Massachusetts Institute of Technology
Inventors:
Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
Abstract: Methods of targeting CD58 signaling to enhance antitumor immunity and overcome resistance to checkpoint blockade therapy. Gene signatures associated with immune fitness were identified. Markers and therapeutic targets for such immunotherapy resistance.
Type:
Application
Filed:
February 2, 2024
Publication date:
September 5, 2024
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, Massachusetts Institute of Technology, The Broad Institute, Inc.
Inventors:
Benjamin IZAR, Johannes C. MELMS, Pratiksha THAKORE, Katie GEIGER-SCHULLER, Aviv REGEV, Chris FRANGIEH
Abstract: The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.
Type:
Application
Filed:
January 2, 2024
Publication date:
September 5, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Jeremiah A. Johnson, Peyton Shieh, Wenxu Zhang
Abstract: Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.
Type:
Grant
Filed:
August 25, 2021
Date of Patent:
September 3, 2024
Assignees:
Massachusetts Institute of Technology, Nanyang Technological University
Abstract: Quantum information processing involves entangling large numbers of qubits, which can be realized as defect centers in a solid-state host. The qubits can be implemented as individual unit cells, each with its own control electronics, that are arrayed in a cryostat. Free-space control and pump beams address the qubit unit cells through a cryostat window. The qubit unit cells emit light in response to these control and pump beams and microwave pulses applied by the control electronics. The emitted light propagates through free space to a mode mixer, which interferes the optical modes from adjacent qubit unit cells for heralded Bell measurements. The qubit unit cells are small (e.g., 10 ?m square), so they can be tiled in arrays of up to millions, addressed by free-space optics with micron-scale spot sizes. The processing overhead for this architecture remains relatively constant, even with large numbers of qubits, enabling scalable large-scale quantum information processing.
Abstract: An electrical joint includes a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions. Also described is a method of forming an electrical joint, comprising forming a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions.
Abstract: A laser micro-machining process called laser-assisted material phase-change and expulsion (LAMPE) micromachining that includes cutting features in a cutting surface of a piece of material using a pulsed laser with intensity, pulse width and pulse rate set to melt and eject liquid material without vaporizing said material, or, in the case of silicon, create an ejectible silicon oxide. Burrs are removed from the cutting surface by electro-polishing the cutting surface with a dilute acid solution using an electric potential higher than a normal electro-polishing electric potential. A multi-lamina assembly of laser-micro-machined laminates (MALL) may utilize MEMS. In the MALL process, first, the individual layers of a micro-electromechanical system (MEMS) are fabricated using the LAMPE micro-machining process. Next, the fabricated microstructure laminates are stack assembled and bonded to fabricate MEM systems.
Abstract: Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.
Type:
Application
Filed:
February 20, 2024
Publication date:
August 29, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Amanda HUBBARD, James IRBY, Rui VIEIRA, William BECK, Richard MURRAY, Andrew PFEIFFER, Thomas TOLAND, William BURKE