Patents Assigned to Massachusetts Institute of Technology
  • Publication number: 20240294643
    Abstract: Methods of targeting CD58 signaling to enhance antitumor immunity and overcome resistance to checkpoint blockade therapy. Gene signatures associated with immune fitness were identified. Markers and therapeutic targets for such immunotherapy resistance.
    Type: Application
    Filed: February 2, 2024
    Publication date: September 5, 2024
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, Massachusetts Institute of Technology, The Broad Institute, Inc.
    Inventors: Benjamin IZAR, Johannes C. MELMS, Pratiksha THAKORE, Katie GEIGER-SCHULLER, Aviv REGEV, Chris FRANGIEH
  • Patent number: 12079693
    Abstract: Quantum information processing involves entangling large numbers of qubits, which can be realized as defect centers in a solid-state host. The qubits can be implemented as individual unit cells, each with its own control electronics, that are arrayed in a cryostat. Free-space control and pump beams address the qubit unit cells through a cryostat window. The qubit unit cells emit light in response to these control and pump beams and microwave pulses applied by the control electronics. The emitted light propagates through free space to a mode mixer, which interferes the optical modes from adjacent qubit unit cells for heralded Bell measurements. The qubit unit cells are small (e.g., 10 ?m square), so they can be tiled in arrays of up to millions, addressed by free-space optics with micron-scale spot sizes. The processing overhead for this architecture remains relatively constant, even with large numbers of qubits, enabling scalable large-scale quantum information processing.
    Type: Grant
    Filed: October 24, 2023
    Date of Patent: September 3, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Hyeongrak Choi, Dirk Robert Englund
  • Patent number: 12077428
    Abstract: Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: September 3, 2024
    Assignees: Massachusetts Institute of Technology, Nanyang Technological University
    Inventors: Subra Suresh, Ming Dao, Ju Li, Zhe Shi
  • Patent number: 12077432
    Abstract: A laser micro-machining process called laser-assisted material phase-change and expulsion (LAMPE) micromachining that includes cutting features in a cutting surface of a piece of material using a pulsed laser with intensity, pulse width and pulse rate set to melt and eject liquid material without vaporizing said material, or, in the case of silicon, create an ejectible silicon oxide. Burrs are removed from the cutting surface by electro-polishing the cutting surface with a dilute acid solution using an electric potential higher than a normal electro-polishing electric potential. A multi-lamina assembly of laser-micro-machined laminates (MALL) may utilize MEMS. In the MALL process, first, the individual layers of a micro-electromechanical system (MEMS) are fabricated using the LAMPE micro-machining process. Next, the fabricated microstructure laminates are stack assembled and bonded to fabricate MEM systems.
    Type: Grant
    Filed: November 8, 2020
    Date of Patent: September 3, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Prashant Patil, Neil Gershenfeld
  • Patent number: 12080445
    Abstract: An electrical joint includes a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions. Also described is a method of forming an electrical joint, comprising forming a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: September 3, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Jose Estrada, Rui Vieira
  • Publication number: 20240287627
    Abstract: The invention, in some aspects, include methods and systems for temporally multiplexed imaging (TMI).
    Type: Application
    Filed: February 27, 2024
    Publication date: August 29, 2024
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yong Qian, Edward S. Boyden
  • Publication number: 20240287487
    Abstract: Aspects of this disclosure provide compositions, strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. Fusion proteins capable of inducing a cytosine (C) to guanine (G) change (i.e., transversion changes) in a nucleic acid (e.g., genomic DNA) are provided. Fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9) and nucleic acid editing proteins or protein domains, e.g., deaminase domains, polymerase domains, base excision enzymes, and/or DNA repair proteins, are also provided. Methods for targeted nucleic acid editing are also provided. Reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9), and nucleic acid editing proteins or domains, are further provided in the present disclosure.
    Type: Application
    Filed: June 10, 2022
    Publication date: August 29, 2024
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, The Regents of the University of California, Massachusetts Institute of Technology
    Inventors: Luke W. Koblan, David R. Liu, Mandana Arbab, Max Walt Shen, Andrew Vito Anzalone, Jeffrey Hussmann
  • Publication number: 20240290520
    Abstract: Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.
    Type: Application
    Filed: February 20, 2024
    Publication date: August 29, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Amanda HUBBARD, James IRBY, Rui VIEIRA, William BECK, Richard MURRAY, Andrew PFEIFFER, Thomas TOLAND, William BURKE
  • Publication number: 20240287549
    Abstract: The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of biofuels and bioplastics from toxic feedstocks.
    Type: Application
    Filed: June 23, 2022
    Publication date: August 29, 2024
    Applicants: Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research
    Inventors: Felix Lam, Gregory Stephanopoulos, Gerald Fink
  • Patent number: 12071663
    Abstract: The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising performing molecular bonding of a porous membrane on an apical or basal surface of an array having a plurality of wells, wherein the molecular bonding substantially isolates each well from adjacent wells.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: August 27, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Todd M. Gierahn, J. Christopher Love, Travis K. Hughes, Marc H. Wadsworth, II, Alexander K. Shalek, Shaina Carroll
  • Patent number: 12070817
    Abstract: Systems, devices, and methods for additive manufacturing are provided that allow for components being manufactured to be assessed during the printing process. As a result, changes to a print plan can be considered, made, and implemented during the printing process. More particularly, in exemplary embodiments, a spectrometer is operated while a component is being printed to measure one or more parameters associated with one or more layers of the component being printed. The measured parameter(s) are then relied upon to determine if any changes are needed to the way printing is occurring, and if such changes are desirable, the system is able to implement such changes during the printing process. By way of non-limiting examples, printed material in one or more layers may be reheated to alter the printed component, such as to remove defects identified by the spectrometer data.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: August 27, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Ryan Wade Penny, Anastasios John Hart
  • Publication number: 20240277872
    Abstract: Disclosed herein are modified niRNAs and modified non-coding RNAs with poly(A) tails containing modified nucleotides and/or secondary structures, which may be made by ligation of a tailing nucleic acid onto the 3? terminal end of an RNA. Also provided are compositions comprising one or more modified mRNAs or modified non-coding RNAs provided herein, and methods of using said compositions for therapeutic or agricultural applications.
    Type: Application
    Filed: May 11, 2022
    Publication date: August 22, 2024
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Xiao Wang, Hailing Shi, Abhishek Aditham
  • Publication number: 20240280576
    Abstract: In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of cancer. In some embodiments, the disclosure relates to protease imaging sensors comprising a scaffold linked to an enzyme-specific substrate that includes a first detectable marker capable of being released from the prostate protease sensor when exposed to an enzyme present in cancer and a tumor imaging agent comprising a second detectable marker that is linked to the scaffold. In some embodiments, the disclosure relates to methods of monitor progression of a tumor in a subject based upon detection of detectable markers in a sample obtained from a subject who has been administered a protease imaging sensor, upon detection of a tumor imaging agent, or any combination thereof.
    Type: Application
    Filed: October 25, 2023
    Publication date: August 22, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Liangliang Hao
  • Publication number: 20240277243
    Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.
    Type: Application
    Filed: April 11, 2024
    Publication date: August 22, 2024
    Applicants: Massachusetts Institute of Technology, UNIVERSIDAD POLITECNICA DE MADRID
    Inventors: Carlos CASTRO-GONZALEZ, Ian BUTTERWORTH, Aurelien BOURQUARD, Alvaro Sanchez FERRO, Jason TUCKER-SCHWARTZ, Alberto PABLO TRINIDAD, MARIA J. LEDESMA CARBAYO, Tom Vettenburg
  • Patent number: 12065635
    Abstract: Organ-on-chip platforms with reduced fluid volumes include circulating fluid volumes of below 1000 ?L, preferably about 500 ?L or less. The platforms are adjustable for culturing cells with varied oxygen demand at various seeding densities. The platforms include at least one lane, wherein each lane includes at least one cell culture well, at least one oxygenator for fluid oxygenation, and a pump system containing at least one pump per lane. The oxygenator may include a separate fluid path for oxygenating the fluid, which allows controlling and measuring the oxygen concentration in the fluid, shortening the diffusion length, and passively diffusing oxygen. Provided are also different configurations for the oxygenator, fluid circulation in the platforms, attachment means for securing scaffolds to culture wells, and pneumatic plates.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 20, 2024
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Daniel Rodion Rathbone, David L. Trumper
  • Patent number: 12064520
    Abstract: Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: August 20, 2024
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Patent number: 12065510
    Abstract: Novel programmable targeting sequences and applications thereof. The targeting sequences can be engineered for binding to proteins, polypeptides, and other macromolecules.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: August 20, 2024
    Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Han Altae-Tran, Linyi Gao, Feng Zhang
  • Patent number: 12068059
    Abstract: Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: August 20, 2024
    Assignees: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology
    Inventors: Vikram Khurana, Chee Yeun Chung, Susan Lindquist, Bonnie A. Berger, Ernest Fraenkel, Jian Peng
  • Patent number: 12065468
    Abstract: The disclosure provides heme binding peptides and their use for treating disorders that can benefit from sequestering free heme.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: August 20, 2024
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Graham C. Walker, Siva Sankari Iyer Mani Sankaran, Vigneshbabu Musuri Periasamy
  • Patent number: 12066679
    Abstract: High-power light absorbers (HPLAs) can exhibit low back-scattered light, mitigate stray light, and withstand high optical power. The absorbers can be used with or without baffling as beam dumps for high-power lasers. An HPLA may include a substrate made of high thermally conductive material with an anti-reflection (AR) coating formed on the substrate. A thin layer of highly absorbing material may be located between the AR coating and substrate. The substrate can be cooled with a fluid, such as water or air.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: August 20, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Steven J. Augst, Peter O'Brien, Jonathan Wilson