Patents Assigned to Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
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Publication number: 20230168255Abstract: The present invention relates to a method of determining the capacity of a Cluster 1 mammalian Transcription Factor (TF) for phase separation and/or the capacity for forming a transcriptional condensate in a sample, including a method of determining the presence, localization and/or morphology of a transcriptional condensate comprising said Transcription Factor, and/or of determining the composition of a transcriptional condensate comprising at least one Cluster 1 mammalian TF and/or of determining the transcriptional activity of the TF or a condensate comprising the TF. Further, the present invention relates to an active agent for use in a method of preventing and/or treating a disorder associated with, caused by and/or accompanied with a dysfunction of a biomolecular condensate comprising at least one Cluster 1 mammalian TF.Type: ApplicationFiled: April 28, 2021Publication date: June 1, 2023Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Denes HNISZ, Shaon BASU, Sebastian MACKOWIAK
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Publication number: 20230133208Abstract: A computer-implemented method for compressing digital data includes obtaining a sequence of digital data values; mapping the sequence of digital data values to a sequence of code words having non-uniform bit lengths; packing the sequence of code words into a sequence of storage words having uniform bit length and corresponding to a fixed-size piece of data handled as a unit by the instruction set or the hardware of a processor; and outputting the sequence of storage words together with a first bitmask indicating the bit length of each code word, wherein in the method is implemented using special purpose vector instructions.Type: ApplicationFiled: April 14, 2020Publication date: May 4, 2023Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventor: Ramin MARX
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Patent number: 11640028Abstract: A hollow-core photonic crystal fiber (HC-PCF) (10) for guiding at least one mode of a light field (1) along a mode guiding section (11) of the HC-PCF (10), comprises an outer jacket (12), an inner cladding (13) and a hollow core (14), which extend along the HC-PCF (10), wherein the inner cladding (13) is arranged on an interior surface of the outer jacket (12) and comprises anti-resonant structures (15) surrounding the hollow core (14), and the hollow core (14) has a mode guiding core diameter (d) provided along the mode guiding section of the HC-PCF (10), and wherein at least one fiber end (16) of the HC-PCF (10) has a light field coupling section (17) in which the hollow core (14) is tapered over an axial coupling section length from a fiber end core diameter (D) at the at least one fiber end (16) to the mode guiding core diameter (d). Furthermore, methods of using the HC-PCF and manufacturing the HC-PCF are described.Type: GrantFiled: May 26, 2021Date of Patent: May 2, 2023Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Sebastian Thomas Bauerschmidt, Patrick Sebastian Uebel, Philip St. J. Russell
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Publication number: 20230098493Abstract: A method for training a mathematical model which describes a light propagation in a reflection microscopy includes radiating a light distribution I0 into an excitation path of a microscope, modulating the light distribution I0 to form a light distribution IA in the excitation path via an optical modulator, reflecting the light distribution IA at a location of a sample in a detection path of the microscope, modulating the light distribution IA to form a light distribution ID in the detection path via a further optical modulator, recording a reflected light distribution ID, repeating the above steps n-fold to generate an n-fold 3-tuple (MA, MD; ID), transferring the n-fold 3-tuple (MA, MD; ID) to a computer to implement a mathematical model F for a light propagation in reflection microscopy, and ascertaining the mathematical model F which describes the light propagation in reflection microscopy based on the n-fold 3-tuple (MA, MD; ID).Type: ApplicationFiled: April 1, 2021Publication date: March 30, 2023Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.Inventors: JOHANNES DOMINIK SEELIG, IVAN VISHNIAKOU
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Patent number: 11613782Abstract: The invention provides a gene signature for use in determining a likelihood of a latent tuberculosis (TB) infection in a subject transitioning to active TB disease. The gene signature comprises at least SEPT4 and BLK, and optionally also GAS6 and/or CD1C. Expression levels of these genes are detected in a sample from the subject, and the ratios of expression of at least two of the above genes are calculated (e.g. SEPT4:BLK, SEPT4:CD1C, GAS6:BLK and/or GAS6:CD1C). A score is assigned to each ratio, the score being indicative of the likelihood of the latent TB infection transitioning into active TB disease, based on the ratio for the respective gene pair. The subject can be identified as having a latent TB infection that is likely to transition into active TB disease or that is not likely to transition into active TB disease based on the score or on the average of the scores.Type: GrantFiled: March 13, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITY OF CAPE TOWN, STELLENBOSCH UNIVERSITY, SEATTLE CHILDREN'S HOSPITAL, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V, UNITED KINGDOM RESEARCH AND INNOVATIONInventors: Sara Suliman, Ethan Greene Thompson, Jayne Suzanne Sutherland, Stefan H. E. Kaufmann, Thomas Jens Scriba, Daniel Edward Zak, Gerhard Walzl
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Publication number: 20230087805Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: ApplicationFiled: September 21, 2022Publication date: March 23, 2023Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
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Patent number: 11608570Abstract: The present invention relates to a method for producing a panel of cells (i.e. a cell library) expressing various different mutant variants of a protein of interest, wherein only one of said mutant variants is expressed per cell from a single gene copy. The present invention also relates to a method or cell library for identifying a mutant variant of a protein of interest having a different or modified biological activity as compared to the corresponding wild-type protein of interest. According to the present invention the identified mutant variant of a protein of interest may be applied for white biotechnology.Type: GrantFiled: July 31, 2017Date of Patent: March 21, 2023Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.Inventors: David Ng, Oliver Griesbeck, Mutlu Erdogan
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Publication number: 20230073506Abstract: The invention relates to a workstation (1), a preparation station (2) and a method for manipulating an electron microscopy grid assembly (3). The workstation (1) comprises a first compartment (101), a first gas inlet (102) for generating an overpressure in the first compartment (101), a first glove (104) and a second glove (105), each being fixed in a respective opening (106, 107) of the workstation (1), wherein the first glove (104) and the second glove (105) are movable in the first compartment (101) to manipulate objects in the first compartment (101), wherein the workstation (1) comprises a port (109) for providing a transfer device (4) for an electron microscopy grid assembly (3) in the first compartment (101).Type: ApplicationFiled: February 4, 2021Publication date: March 9, 2023Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.Inventors: Sebastian TACKE, Stefan RAUNSER
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Publication number: 20230067910Abstract: The present invention relates to compounds represented by general formula (Ia), (Ib), (IIa) or (IIb). These compounds are suitable for imaging alpha-synuclein and for diagnosing diseases which are associated with the aggregation of alpha-synuclein. The compounds are also useful for treating and preventing diseases which are associated with the aggregation of alpha-synuclein.Type: ApplicationFiled: November 19, 2020Publication date: March 2, 2023Applicants: MODAG GMBH, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Armin GIESE, Felix SCHMIDT, Daniel WECKBECKER, Andrei LEONOV, Sergey RYAZANOV, Christian GRIESINGER, Bernd PICHLER, Kristina HERFERT, Andreas MAURER, Laura KÜBLER, Sabrina BUSS
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Patent number: 11595133Abstract: A quantum device includes a non-reciprocal transmission structure, wherein the transmission structure is designed such that for first waves traversing the transmission structure in a forward direction the phases of the first waves are at least partially conserved, and for second waves traversing the transmission structure in a backward direction, the phases of the second waves are at least partially replaced by random ones, such that the phase conservation is more pronounced in the forward direction than in the backward direction.Type: GrantFiled: April 5, 2019Date of Patent: February 28, 2023Assignee: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.Inventors: Jochen Mannhart, Daniel Braak
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Patent number: 11569918Abstract: A quantum device comprising a transmission structure, wherein based on quantum collapse, interference and selective absorption the transmission structure is designed such that quantum waves emitted by at least two bodies, for example, by thermal excitation, are passed preferentially to a subset of these bodies.Type: GrantFiled: September 12, 2019Date of Patent: January 31, 2023Assignee: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.Inventors: Jochen Mannhart, Daniel Braak
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Patent number: 11562253Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.Type: GrantFiled: February 18, 2019Date of Patent: January 24, 2023Assignees: Baycrest Centre for Geriatric Care, Codebox Computerdienste GmbH, Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften e.V., Universite D'Aix MarseilleInventors: Anthony Randal McIntosh, Jochen Mersmann, Viktor Jirsa, Petra Ritter
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Patent number: 11552442Abstract: A laser device (100), being configured for generating laser pulses by Ken lens based mode locking, comprises a laser resonator (10) with a plurality of resonator mirrors (11.1, 11.2, 11.Type: GrantFiled: January 23, 2019Date of Patent: January 10, 2023Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V., LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHENInventors: Oleg Pronin, Ferenc Krausz, Sebastian Groebmeyer, Jonathan Brons
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Publication number: 20220404242Abstract: The present invention relates to rhodamine-type fluorophores being present in two states, a cell-permeable non-florescent form and a fluorescent form. The present invention also relates to use of the fluorophores in staining and live cell fluorescence imaging. The compounds have general formula (10) or the general formula (10?).Type: ApplicationFiled: December 6, 2019Publication date: December 22, 2022Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.Inventors: Kai JOHNSSON, Lu WANG
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Patent number: 11520370Abstract: A circuit for delaying an electric signal (CI), comprises an input for the electric signal (CI); an input for a control signal (EI); a first storage element (U5) for storing the control signal; a delay element for delaying the electric signal; and an output for the delayed electric signal (CO). According to the invention, the electric signal is delayed, based on the stored control signal. The delay circuit is employed in a fast all-digital clock frequency adaptation circuit for voltage droop tolerance.Type: GrantFiled: March 11, 2019Date of Patent: December 6, 2022Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.Inventors: Christoph Lenzen, Matthias Függer, Ben Wiederhake, Attila Kinali, Mordechai Medina
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Patent number: 11505586Abstract: This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to ?-Netrins comprising SEQ ID NO.:1, 2 or 3, and variants thereof, with ?-Netrins, and the use of this interaction to disrupt ?-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to ?-Netrins. Further, the invention relates to fragments of ?-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against ?-Netrins inhibiting binding of ?-Netrins to Netrin receptors.Type: GrantFiled: August 28, 2019Date of Patent: November 22, 2022Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Christian Söllner, Xuefan Gao, Christiane Nüsslein-Volhard
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Patent number: 11491674Abstract: A method where a propeller is set into locomotion relative to a medium at least partially surrounding the propeller. An actuator induces a rotation of the propeller relative to the medium and about a rotational axis of the propeller, and the propeller converts its rotational movement into locomotion relative to the medium. The aspect ratio of at least one cross-section of the propeller is three or more. Also a helical or modifiedly helical propeller for converting rotational movement of the propeller into locomotion of the propeller relative to a medium at least partially surrounding the propeller, where the aspect ratio of at least one cross section of the propeller is three or more. And a method of producing a propeller, including the step of providing a plate extending along the helical axis, where the aspect ratio of at least one cross section of the plate is three or more.Type: GrantFiled: April 11, 2018Date of Patent: November 8, 2022Assignee: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.Inventors: Tian Qiu, Peer Fischer
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Patent number: 11491715Abstract: A method of fabricating a component (1) comprises the steps of providing precursor material in a working medium, creating acoustic forces and positioning the precursor material in the working medium under the effect of the acoustic forces, so that a material distribution is formed, which has a shape of the component to be fabricated, and subjecting at least one of the material distribution and the working medium to a fixation, so that the precursor material of the material distribution or the working medium surrounding the material distribution is bound, wherein the step of creating the acoustic forces includes generating an acoustic interference pattern (5), and the material distribution (4) is formed by moving the precursor material (2) towards energy extrema of the acoustic interference pattern (5). Furthermore, an apparatus (100) for fabricating a component (1) is described.Type: GrantFiled: December 18, 2015Date of Patent: November 8, 2022Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.Inventors: Kai Melde, Peer Fischer
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Publication number: 20220324893Abstract: The present invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) nitrate as a metal cation ligand and (ii) a metal cation chelating domain comprising a chelating ligand and a label and/or carrier. This complex can be used for attaching a label and/or a carrier to a target molecule, preferably a protein. The attachment of the label or carrier via the complex of the invention involves the replacement of the metal cation ligand with a coordinating group of the target molecule so that a product complex with the target molecule as primary ligand in the coordination sphere of the metal cation is formed. Accordingly, the present invention also provides for uses and methods involving the attachment of a label and/or carrier to a target molecule.Type: ApplicationFiled: June 18, 2020Publication date: October 13, 2022Applicants: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Universität HeidelbergInventors: Amelie S. BENK, Lucia T. BENK, Seraphine WEGNER, Peter COMBA, Joachim P. SPATZ
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Publication number: 20220315942Abstract: The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.Type: ApplicationFiled: August 5, 2020Publication date: October 6, 2022Applicants: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Heinrich-Heine-Universität DüsseldorfInventors: Lennart Schada Von Borzyskowski, Tobias Jürgen Erb, Andreas Paul Michael Weber, Marc-Sven Roll